Experimental Pathology
Pathology is the study of diseases and disease
processes. The Experimental Pathology
track faculty investigate molecular mechanisms that underly diseases which
affect specific organ systems. Studies deal with 1) the etiology, or specific
molecular and cellular defects that cause human diseases, and 2) pathogenesis,
or the mechanisms that result in the presenting signs and symptoms associated
with disease conditions. Our goals are
to provide instruction that illustrates those mechanisms and considers
hypothesis-based approaches to their analysis.
The recommended curriculum draws from the classic and emerging
literature to illustrate mechanisms of disease.
There is strong emphasis on a critical appraisal of the strengths and
limitations of experimental approaches and the diverse animal models used in
disease research. The Experimental
Pathology track includes varied topics that are broadly grouped under the
headings: Acquired immune deficiency syndrome, developmental neurobiology and cardiology, ion channels, immunopathology,
and mechanisms of cell signaling and cancer.
Recognizing these diverse research interests, the suggested curriculum
for students considering the track is broadly-based. A combination of electives are offered that
provide a research-oriented consideration of etiology and pathogenesis,
including short 1-4 unit courses that focus on specific topics in pathobiology. Didactic teaching components of the track are
supplemented by tutorial and research conferences in which graduate students
and postdoctoral fellows gain experience by presenting original data in
research seminars and insight from diverse scientific viewpoints. Student
fellowship opportunities are available through several NIH-sponsored training
grants.
Recommended courses:
PATH221/MMG221
Immunopathogenic Mechanisms of
Disease
PATH222/MMG222 Molecular
Pathogenesis of Viral Infections
PATH225/MMG225 Molecular Mechanisms of Human Disease
PATH
230D Principles of Experimental
Pathology
PATH
231A Pathology of Cardiovascular
Diseases
PATH
232A Pathology of Pulmonary
Diseases
PATH
233A Pathology of Renal Diseases
PATH
234A,B Pathology of Gastrointestinal
Diseases
PATH
235A,B Pathology of Genitourinary
Tract Diseases
PATH
236B Graduate Neuropathology
BC212:
Signal Transduction and
Growth Control
DC231B:
Molecular, Cellular &
Developmental Neurobiology
MMG215
Molecular Immunology
Under Development: Animal Models of Human
Disease
Experimental Pathology Faculty
Track coordinator - John J.
Krolewski, +
Rainer K. Brachmann,
+
M.D., Assistant Professor of Medicine and Biological Chemistry
Cancer genetics; chromatin & transcriptional
regulation; tumor suppressor gene p53
Jefferson
Y. Chan, +
M.D./Ph.D., Assistant Professor of Pathology
Regulation of genes associated with oxidative stress
K. George Chandy,
+
M.D./Ph.D., Professor of Physiology & Biophysics and Microbiology &
Molecular Genetics
Molecular biology and structure of ion channels; novel
therapeutic agents
Luis de la
Maza
Chlamydia pathogenesis
Robert
Edwards
Pathogenesis of
inflammatory bowel disease
Agnes
Henschen-Edman, + M.D./Ph.D., Professor of Molecular
Biology & Biochemistry
Protein structure, function, post-translational
modification; fibrinogen
Taosheng Huang, +
M.D./Ph.D., Assistant Professor of Pediatrics and Developmental & Cell
Biology
Molecular basis of genetic diseases in human
Anthony
A. James, + Ph.D., Professor of Molecular
Biology & Biochemistry
Malaria parasite development; genetic manipulation of
insect vectors
John
J. Krolewski, + M.D./Ph.D., Associate Professor of
Pathology and Biological Chemistry
Signal transduction pathways regulating the growth and
death of normal and neoplastic cells
J. Lawrence Marsh, +
Ph.D., Professor of Developmental & Cell Biology
Regulation of growth factor signaling in patterning,
regeneration and oncogenesis
Dan Mercola, + M.D./Ph.D., Professor of Pathology
Translational
research in prostatic cancer
Edwin
S. Monuki, + M.D./Ph.D., Assistant Professor of
Pathology and Developmental Biology
Cerebral cortex development and disease
Andre
J. Ouellette, + Ph.D., Professor of Pathology and
Microbiology & Molecular Genetics
Mechanisms and regulation of innate immunity in mammalian
epithelia
Ellena
Peterson
Chlamydia pathogenesis
W. Edward
Robinson, + M.D./Ph.D., Professor of Pathology
and Microbiology & Molecular Genetics
Pathogenesis of retrovirus infections; molecular
mechanisms of integration
Michael
E. Selsted, + M.D./Ph.D., Professor of Pathology
and Microbiology & Molecular Genetics
Molecular effectors of mammalian innate immunity
Andrea
J. Tenner, + Ph.D., Professor of Molecular
Biology & Biochemistry
Innate immunity; the roles of complement and phagocytes
in health and disease
Ping
Wang, +
M.D., Associate Professor of Medicine, Biological Chemistry and Physiology
& Biophysics
Molecular hormone actions in the normal and diseased
heart