Mechanisms of Gene Expression Graduate Training Program
The processes of differential
gene expression generate extraordinarily complex spatio-temporal
networks of gene and protein interactions. To understand the molecular
mechanisms of health and disease, we need to understand these networks. The
researchers of the several laboratories that comprise the Mechanisms of Gene
Expression Research Group at UCI study these networks and interactions in a
broad spectrum of experimental systems from bacteria to man. These studies
range from the basic biophysical properties of protein DNA interactions and
structures to complex genetic control systems for the regulation of human
metabolism. Although there is much conceptual overlap among the research
approaches in each research laboratory, each research group possesses expertise
in specific experimental systems and, in many cases, employ
unique technologies. These conceptual and technological approaches are shared
among all of the research groups at Gene Expression
Club, a
monthly research meeting. This intellectual cross-fertilization facilitates the
research objectives of each research group and provides a broad training for
graduate education in the participating laboratories. The specific research
interests of the faculty directors of the research laboratories of the
Mechanisms of Gene Expression Research Group are listed below.
Courses Offered:
Required:
MBB
206 (Regulation of Gene Expression, Core Course)
Electives:
BC 225: Chromatin Structure and Function (4) W
every other year
M&MG 225:
Molecular Mechanisms of Human Disease (3) S
MB&B 205:
Topics in Viral Gene Expression (4) W
MB&B 217A:
Principles of Cancer Biology (4) W of even years
MB&B 217B:
Principles of Cancer Biology (4) W of odd years
M&MG 201ABC: Research Topics in Microbiology and Molecular Genetics (1) FWS
Mechanisms of Gene Expression Faculty
Track coordinator - Klemens Hertel, +
Bogi Andersen, + Ph.D., Assistant Professor of Medicine
and Biological Chemistry
Transcriptional regulation in the developmental biology
of epidermis and mammary gland
Ruslan Aphasizhev, +
Ph.D., Assistant Professor of Microbiology and Molecular Genetics
Molecular biology of trypanosomes; mitochondrial RNA
editing; mechanisms of template-independent nucleotide recognition and
transfer.
Bruce Blumberg, +
Ph.D., Assistant Professor of Development & Cell Biology
Gene regulation by nuclear hormone receptors in
vertebrate development and adult physiology
Rainer K. Brachmann, + M.D., Assistant Professor of
Medicine and Biological Chemistry
Cancer genetics; chromatin & transcriptional
regulation; tumor suppressor gene p53
Melanie
Cocco, + Ph.D., Assistant Professor of
Molecular Biology & Biochemistry
NMR spectroscopy, DNA-binding proteins, membrane
proteins, cancer
Xing Dai, + Ph.D.,
Assistant Professor of Biological Chemistry
Role of the regulatory proteins Ovo
in germ cell and epidermal differentiation
Klemens Hertel, +
Ph.D., Assistant Professor of Microbiology & Molecular Genetics
Regulation of gene expression by alternative splicing
Lan
Huang, +
Ph.D., Assistant Professor of Physiology & Biophysics and Development &
Cell Biology
Proteomics/mass spectrometry, signaling networks,
posttranslational modifications, biomarkers in cancer
Peter Kaiser,
+
Ph.D., Assistant Professor of Biological Chemistry
Cell cycle control; regulation of proteins by ubiquitination
John
J. Krolewski, + M.D./Ph.D.,
Associate Professor of Pathology and Biological Chemistry
Signal transduction pathways regulating the growth and
death of normal and neoplastic cells
Eva Y.-H. P.
Lee, +
Ph.D., Professor of Biological Chemistry and Developmental & Cell Biology
Cell cycle checkpoint pathways and molecular genetic
studies of breast cancer using mouse models
Ulrike
Luderer, + Ph.D., Assistant Professor of
Medicine, Occupational & Environmental Medicine and Developmental &
Cell Biology
Regulation of glutathione synthesis and protective role
of glutathione in ovarian follicules
Edwin
S. Monuki, + M.D./Ph.D.,
Assistant Professor of Pathology and Developmental Biology
Cerebral cortex development and disease
Timothy
F. Osborne, + Ph.D., Professor of Molecular
Biology & Biochemistry
Transcriptional regulation of human cholesterol
biosynthesis and nutritional homeostasis
Maike
Sander, +
M.D., Assistant Professor of Developmental & Cell Biology
Transcriptional control of CNS and pancreas development
in mice
Rozanne M. Sandri-Goldin, +
Ph.D., Professor of Microbiology & Molecular Genetics
Mechanisms of RNA export and splicing inhibition
Paolo Sassone-Corsi, +
Ph.D., Distinguished Professor and Chair of Pharmacology
Mechanisms of gene expression and epigenetics
Donald
F. Senear, + Ph.D., Associate Professor of
Molecular Biology & Biochemistry
Interactions of proteins and DNA in transcriptional
regulation
Ming
Tan, +
M.D., Associate Professor of Microbiology & Molecular Genetics, and
Medicine
Gene expression and pathogenesis in Chlamydia trachomatis
Paul Vrana, + Ph. D., Assistant Professor of
Biological Chemistry
Control of mammalian growth through imprinting
Doug
Wallace, + Ph.D., Professor of Biological
Chemistry and Ecology & Evolutionary Biology
Human mitochondrial genetics and molecular medicine
Rahul
Warrior, + Ph.D., Assistant Professor of
Developmental & Cell Biology
Nuclear migration in developoment
and disease; Transcriptional response to growth factor signaling
Marian
L. Waterman, + Ph.D., Associate Professor of
Microbiology & Molecular Genetics
Regulation of LEF-1 gene expression in lymphocytes and
cancer
Kyoko Yokomori, + Ph.D., Assistant Professor of
Biological Chemistry
Molecular mechanisms of chromosome dynamics and gene
regulation