Virology Graduate Training Program



    The Virology Track is comprised of faculty, students, postdoctoral fellows, and laboratory staff who have common research and teaching interests in virology and related disciplines.  It shares a common core curriculum with all other tracks in the MBG&B graduate program.  The research programs of faculty participants include the study of genome replication, viral specific transcription, viral RNA processing, viral translation, viral protein processing, and assembly and transport of viral structural proteins.  There are also research efforts aimed at understanding virus-host interactions that include studies of how virus gene products alter and program host functions, alteration of host regulatory molecules, growth control, cell cycle regulation, differentiation control, the role of the innate immune response, the integration specificity of viral genomes, and the subversion of host functions for virus gene expression.  The viruses/viral systems being studied include murine leukemia virus, human immunodeficiency virus (HIV), Jaagsiekte sheep retrovirus, retrotransposons in yeast, poliovirus and human rhinovirus, coronaviruses, papillomavirus, herpes simplex virus, Epstein-Barr virus, polyomavirus, and adenovirus.

    The training program for the Virology Track includes core elective courses in viral gene expression, molecular pathogenesis of viral infections, and immunopathogenic mechanisms of disease.  Students in the Virology Track also participate in a seminar series sponsored by the Center for Virus Research. Seminars are generally held at noon every other Friday during the academic year.  Leading national researchers are invited to present their work in different areas of virology, gene regulation, cell transformation, and a variety of topics in molecular biology and molecular genetics.  Alternating with the seminars by invited outside speakers are research-in-progress seminar presentations by graduate students and postdoctoral fellows in the laboratories of participating faculty.  These seminars provide a stimulating forum for exchanges of scientific ideas and information and for a critical analysis of data generated by the graduate students and fellows making the oral presentations.

 

 



Elective Courses:

        MBB 205:  Topics in Viral Gene Expression
        MMG 222: Viral Pathogenesis (Offered every other year)
        MMG 221: Immunopathogenic Mechanisms of Disease (Every other year)
        Virology Seminar Series (Sponsored by the Center for Virus Research ORU)

 


Virology Faculty

Track coordinator  - Ingrid K. Ruf, + 

Hans Ulrich Bernard, + Ph.D., Professor of Molecular Biology & Biochemistry
    Gene expression of papillomaviruses; progression of cervical cancer
Michael J. Buchmeier,  Ph.D., Professor of Molecular Biology & Biochemistry

     Viral biology and pathogenesis, structural and functional proteomics of viruses, and biodefense related pathobiology

David Camerini, + Ph.D., Assistant Professor of Molecular Biology & Biochemistry
    Pathogenesis and molecular biology of HIV-1
Hung Fan, + Ph.D., Professor of Molecular Biology & Biochemistry
    Molecular biology and pathogenesis of mouse, human, and sheep retroviruses
Paul Gershon, + Ph.D. Professor of Molecular Biology & Biochemistry

    Virus structure and enzymes

Thomas E. Lane, + Ph.D., Associate Professor of Molecular Biology & Biochemistry
    Molecular/immunopathological mechanisms of virus-induced demyelinating disease
Alexander McPherson, + Ph.D., Professor of Molecular Biology & Biochemistry and Physiology & Biophysics
    Molecular structure of biological materials
W. Edward Robinson, + M.D./Ph.D., Professor of Pathology and Microbiology & Molecular Genetics
    Lentivirus (HIV and SIV) integration, replication, and pathogenesis
Ingrid K. Ruf, + Ph.D., Assistant Professor of Molecular Biology & Biochemistry
    Molecular mechanisms of Epstein-Barr Virus latency and pathogenesis,  biology of small RNAs
Suzanne B. Sandmeyer, + Ph.D., Professor of Biological Chemistry and Microbiology & Molecular Genetics
    Molecular genetics of a position-specific yeast retrovirus-like element
Rozanne M. Sandri-Goldin, + Ph.D., Professor of Microbiology & Molecular Genetics
    Structure and functional analysis of a multifunction herpes virus regulatory protein
Bert L. Semler, + Ph.D, Professor of Microbiology & Molecular Genetics
    Replication of picornavirus RNAs; RNA-protein and protein-protein interactions
Steven L. Wechsler, + Ph.D. Professor of Ophthalmology Research and Microbiology & Molecular Genetics

    Herpes simplex virus latency, reactivation and recurrent disease

Luis P. Villarreal, + Ph.D, Professor of Molecular Biology & Biochemistry
    Virus evolution: evolution of persistent viruses and effects on host evolution; applied virology laboratory for anti-viral therapeutics
Gregory A. Weiss, + Ph.D., Associate Professor of Chemistry and Molecular Biology and Biochemistry
    Harnessing viruses for protein engineering, biosensors, drug resistance avoidance, and single molecule studies.

For more information, please see the Center for Virus Research Web Page


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