Event Calendar Detail

Date & Time: Friday 03/06/2009 12:00 PM - 1:00 PM
Hosted By: Molecular Biology & Biochemistry
Speaker: James Bowie - Professor
Department of Chemistry and Biochemistry
UCLA - DOE
Subject: What drives membrane protein folding?
Location: Natural Sciences I
Room 1114
Irvine, CA 92697
Contact: Carolyn Griffin
Phone: (949) 824-4915
carolyng@uci.edu
Description:
Recent publications include: Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants. Gorman PM, Kim S, Guo M, Melnyk RA, McLaurin J, Fraser PE, Bowie JU, Chakrabartty A. BMC Neurosci. 2008 Jan 30;9:17. Point mutations in membrane proteins reshape energy landscape and populate different unfolding pathways. Sapra KT, Balasubramanian GP, Labudde D, Bowie JU, Muller DJ. J Mol Biol. 2008 Feb 29;376(4):1076-90. Epub 2007 Dec 23. Transmembrane domain of myelin protein zero can form dimers: possible implications for myelin construction. Plotkowski ML, Kim S, Phillips ML, Partridge AW, Deber CM, Bowie JU. Biochemistry. 2007 Oct 30;46(43):12164-73. Epub 2007 Oct 4. Janus model of the Na,K-ATPase beta-subunit transmembrane domain: distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization. Barwe SP, Kim S, Rajasekaran SA, Bowie JU, Rajasekaran AK. J Mol Biol. 2007 Jan 19;365(3):706-14. Epub 2006 Oct 31. A limited universe of membrane protein families and folds. Oberai A, Ihm Y, Kim S, Bowie JU. Protein Sci. 2006 Jul;15(7):1723-34. Flip-flopping membrane proteins. Bowie JU. Nat Struct Mol Biol. 2006 Feb;13(2):94-6.

 
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