Behnoosh Afghani, M.D. Pediatrics
RESEARCH DESCRIPTION: Research in different areas related to A) Infection prevention, including hand hygiene compliance in healthcare workers and surveillance of hospital acquired infections through chart studies, B) Mentorship: Needs of students for mentorship will be assessed and the information will be used to guide planning, implementation, evaluation, and decision making to develop mentorship programs related to the field of healthcare. Projects will be conducted at the UCI Medcial Center. REQUIREMENTS TO PARTICIPATE: Students must complete requirements for human subject research and Biosafety 194 and Research Ethics course and have strong analytical and social skills. Familiarity with the Excel program will be helpful. COURSE COMPLETION: Students must be in their junior or senior years. GRADE POINT AVERAGE: Minimum GPA of 3.0 is required. TIME COMMITMENT PER WEEK: 3-4 hours per week is required but the hours can be spread throughout the week. Students can continue the project throughout the year and get units each quarter. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Commitment and enthusiasm in finishing assignments and helping with data analysis. OFFICE LOCATION: UCIMC, 101 City Drive, Bldg 58, Orange, CA 92868
Behnoosh Afghani: firstname.lastname@example.org, (714) 456-5726
Anshu Agrawal, Medicine/Immunology
The focus of my lab is to understand the biology of dendritic cells (DC) of the immune system. DCs are the major antigen presenting cells that are critical mediators of both innate and adaptive immune responses. We are mainly interested in understanding the differences in the functioning of DCs between young and aged human subjects and the consequences and mechanisms underlying these differences. We study the activation of DCs by Toll like receptors (TLRs) ligands by Flow cytometry and ELISA. Signaling differences are studies by Western and flow cytometry. The priming of T cells by DCs forms a major component of our adaptive immune system studies. Office location: Med Sci I, C-238 Should work for at least 1 school yr. GPA: 3.5+. 12-15 hrs/wk.
Anshu Agrawal: email@example.com, (949) 824-7706
Thomas Ahlering, M.D. Urology
RESEARCH DESCRIPTION: Dr. Ahlering’s research focuses on the diagnosis, treatment, and clinical outcomes of prostate cancer. Dr. Ahlering is continuously trying to find new methods of faster return to continence and potency post radical prostatectomy. The Bio199 student will be involved in clinical research projects by helping to carry out studies, collecting data, maintaining study databases and analyzing data. He/She will be expected to meet with Dr. Ahlering and his research team on a weekly or biweekly basis to give updates on the clinical outcomes and findings of the data analysis. The student may be a co-author on manuscripts depending on the level and quality of work and analysis produced during his/her time as part of the research team. REQUIREMENTS TO PARTICIPATE: Major in the Biology Department At least a third year undergraduate COURSE COMPLETION: To be determined GRADE POINT AVERAGE: Minimum 3.0 GPA TIME COMMITMENT PER WEEK: Two to three days a week, about 10 hours. NUMBER OF UNITS REQUIRED: 2 – 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Attendance, database upkeep, and quality of work. OFFICE LOCATION: UCI Medical Center, City Tower 333 City Blvd West, Ste 2100 Orange, CA 92868
Victor Huynh: firstname.lastname@example.org, (714) 456-8176
Steven Allison, Ecology and Evolutionary Biology
RESEARCH DESCRIPTION: My lab works at the interface between microbiology, ecosystem ecology, and global change. We study how microbes “make a living” in the environment, and how they affect ecosystem processes, such as the break-down of dead plant material and the cycling of nutrients. Student projects may focus on field work, laboratory studies, and/or computer modeling. Summer and academic year positions are available. REQUIREMENTS TO PARTICIPATE: Students should be prepared to develop independent projects and spend at least 10 hours per week on research. A multi-quarter commitment is strongly preferred, and students will be expected to participate in lab activities and meetings. To apply for a position, please visit http://allison.bio.uci.edu , download the Bio 199 Research Application form, and send the form back to email@example.com. MEANS OF EVALUATION: grades will be based on time committed to the project and the quality of research. OFFICE LOCATION: 3108 Bio Sci 3.
Steven Allison: firstname.lastname@example.org, (949) 824-2341
Aileen J. Anderson, Ph.D. Physical Medicine & Rehab & Anatomy & Neurobiology
RESEARCH DESCRIPTION: Dr. Anderson is an Associate Professor in Physical Medicine & Rehabilitation and Anatomy & Neurobiology, with 20 years of research experience focusing on the mechanisms and pathways of central nervous system degeneration and regeneration. She is a member of the Stem Cell Research Center, Reeve-Irvine Research Center, Institute for Memory Impairments and Neurological Disorders, and Center for Immunology at the University of California at Irvine. In addition to her laboratory at UCI, she is the Director of the Christopher and Dana Reeve Paralysis Foundation (CDRF) Spinal Cord Injury (SCI) Research Core Facility, and a part of the CDRF International Consortium on Spinal Cord Injury. The CDRF SCI Core was established in 2001 as the first foundation-funded initiative of its kind, with the goal of enabling interdisciplinary and cross-institutional access to SCI animal models and training as an integral part of multiple CDRF research initiatives. Dr. Anderson’s own research is focused on two principal goals. First, investigating the interactions of transplanted stem cell populations within the injured niche, including the role of the evolving inflammatory microenvironment in stem cell fate and migration decisions. Second, investigating the role of inflammatory mechanisms in degeneration and regeneration in the injured CNS, particularly the role of the innate immune response and complement pathways in these conflicting but intertwined processes. Much of the research in Dr. Anderson’s laboratory bridges the junction between seeking to understand mechanism at the basic neuroscience level, and identifying translational neuroscience strategies to ameliorate the cellular and histopathological deficits associated with SCI to promote recovery of function. REQUIREMENTS TO PARTICIPATE: Attendance of Lab Meetings at least 1 qtr per year Completion of assigned lab safety training COURSE COMPLETION: Bio 194S GRADE POINT AVERAGE: 3.5 GPA TIME COMMITMENT PER WEEK: 12 hours per week and a minimum of 2 years NUMBER OF UNITS REQUIRED: Minimum enrollment of 3 units OTHER: On the last day of instruction of both the fall and winter quarter, students are required to turn in a 1-2 page summary of work completed. This can include background information obtained by reading the literature, details about a technique learned, and/or data generated. At the end of spring quarter, this paper will be replaced with a 15-minute scientific talk presented to the lab. All 199s are required to attend these talks. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work and data collection, proper use of lab equipment, following appropriate lab and university-mandated safety protocols, initiative and overall enthusiasm for research. LOCATION OF RESEARCH: 845 Health Science Road, 2030 Sue & Bill Gross Hall.
Aileen Anderson: email@example.com, (949) 824-6750
Hoda Anton-Culver, Ph.D. Epidemiology
RESEARCH DESCRIPTION: Hoda Anton-Culver, PhD.focuses her research in the area of genetic epidemiology of cancer. One study funded by the NCI as an R01 combines techniques in genetic epidemiology and molecular genetics to define and characterize inherited breast/ovarian cancer in the population and in the familial component of the disease. This study began in the late 1980’s and continues to date through competing renewals of the NCI funding. Another NCI funded R01, focuses on colon and rectum cancers to study the effects of genetic influence on the mismatch repair genes as they interact with diet, physical activity, and other factors that may influence the risk for colorectal cancer and estimate genetic and environmental interaction. In addition to breast and colorectal cancer she has funding to investigate genetic and environmental influences on the risk of multiple other cancers including prostate, malignant melanoma and childhood cancer. She has been awarded several significant awards in cancer genetics from the National Cancer Institute. These awards include the (1) “UCI-UCSD Cancer Genetics Network” to collaborate with other centers to investigate the genetic basis of human cancer susceptibility and identify means to address the public health issues associated with human cancer genetics; (2) The “NCI Cancer Genetics Network Informatics Center at UCI” supports the cooperative of Cancer Genetics Networks as the sole Informatics Center responsible for the design, implementation, and maintenance of an information management system that supports the Network-wide research protocols REQUIREMENTS TO PARTICIPATE: Biology, Genetics, Statistics, and Epidemiology COURSE COMPLETION: at least 2 courses of the above are required GRADE POINT AVERAGE: GPA 3.0 minimum TIME COMMITMENT PER WEEK: 8- 12 hours NUMBER OF UNITS REQUIRED: 2-3. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Practical, oral and written evaluation. OFFICE LOCATION: 224 Irvine Hall, Zot 7550
Hoda Anton-Culver: firstname.lastname@example.org, (949) 824-7416
Manny Azizi, Ecology and Evolutionary Biology
RESEARCH DESCRIPTION: Research in the Azizi Lab is focused on understanding the physiology and function of the musculoskeletal system. This work aims to elucidate how the basic properties of muscle cells ultimately limit an animal’s maximum performance. This research spans multiple levels of biological organization and independent research projects may focus on in vitro studies of muscle tissue or mechanical studies of animal movement. REQUIREMENTS TO PARTICIPATE: Strong interest in physiology. Comfortable working with animals. A multi-quarter commitment preferred. Students are expected to participate in weekly lab meetings. COURSE COMPLETION: Bio194. GRADE POINT AVERAGE: 3.0 or above. TIME COMMITMENT PER WEEK: Minimum of 10 hours per week FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of research. LOCATION OF RESEARCH: McGaugh 5409.
Manny Azizi: email@example.com, (949) 824-7414
Tallie Z. Baram, M.D., Ph.D. Anatomy/Neurobiology;Pediatrics
Neuroscience Research. Cellular mechanisms of vulnerability of the developing brain to febrile and other seizures. Mechanisms of excitation-dependent neuroplasticity. Molecular neurobiological mechanisms of response to stress during development.
Tallie Baram: firstname.lastname@example.org, (949) 824-1131, (949) 824-1063
Stanley Bassin, Ed.D. Cardiology
Lab or building where research will be conducted: Field Work in Orange County and Long Beach with Community Health Organizations. CURRENT RESEARCH INTERESTS AND DESCRIPTION: Conducting Research to prevent chronic disease (cardiovascular, diabetes, obesity and build bone health) through lifestyle interventions in minority communities through school and community programs. Research Studies currently involve preventing type 2 diabetes with middle school children and their families as well as the establishment of network for communicating research findings to the diverse population of Orange County PREREQUISITES: Upper division students who have completed Bio 194 and ethics course Completion of all human subject tutorials and prerequisites, biology or statistical background (with introductory courses in statistics) highly recommended. Prior work or volunteer experience working with diverse communities. Strong English written and verbal skills necessary. Grade Point average of 3.0 or higher SELECTION CRITERA: Resume, experience in and /or interest in community health, writing experience, and social skills to work in diverse communities. Upper Division standing. Interview will be required. Please submit resume of course work, volunteer experience and number of hours available per week via e-mail to email@example.com UNIT REQUIREMENT: Number of Units/Quarter 2 or more units/per quarter (4 hours per unit) Hours/Week 8 hrs per week GRADING BASIS: Examination: Initiative and research paper to be submitted and /or develop a proposal for funding with a community organization. UCI faculty member will evaluate quantity of Work Research paper and / or funding proposal for content and exposition
Stanley Bassin: firstname.lastname@example.org, (714) 456-8730
Anjan Batra, M.D. Pediatrics
RESEARCH DESCRIPTION: There is a high incidence of arrhythmias in patients undergoing the Fontan surgery for palliation of single ventricle hearts. The incidence of these arrhythmias using two different surgical techniques is unclear. The purpose of this research is to compare the incidence of arrhythmias between these 2 different surgical techniques (lateral tunnel vs. extracardiac conduit). REQUIREMENTS TO PARTICIPATE: Understanding of human cardiac anatomy. TIME COMMITMENT PER WEEK: 10 hours NUMBER OF UNITS REQUIRED: 3 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Completion of an abstract. OFFICE LOCATION: 101 The City Dr.
Anjan Batra: email@example.com, (714) 456-2331
Lbachir BenMohamed, Ph.D. Ophthalmology and Center for Immunology
Lbachir BenMohamed, Ph.D. and Anthony B. Nesburn, M.D. RESEARCH DESCRIPTION: Immunology of Herpes Simplex Virus (HSV) Type 1 Latency and Pathogenesis The aim of this study is listed in three sections: 1) To develop a clinically acceptable vaccine strategy to reduce or eliminate ocular and genital herpes infection including recurrent disease. 2) Eventually, the candidate vaccines developed in mice will be tested in rabbits and humans. Techniques used in this project: Immunology, virology, and molecular biology – techniques that include vaccine studies in animal models. 3) To investigate if (1) LAT is involved in dendritic cells (DC) modulation (2) HSV-1 interferes with the migratory activity of DC in vivo (trafficking or homing), (3) LAT also plays a role in this viral activity. Development of immunotherapeutic and immunoprophylactic strategies against various cancers 1) The aim of this study is to develop a clinically acceptable Glyco lipopeptide vaccines to reduce or eliminate tumor cells 2) The candidate vaccines developed will be tested in mouse model of cancers. Techniques used in this project: Immunology, virology, and molecular biology – techniques that include vaccine studies in animal models. REQUIREMENTS TO PARTICIPATE: Requirements – General background in biology/biochemistry/immunology/virology, oncology and/or infectious diseases. Strong motivation, good organizational skills, quick study and receptive to taking work direction. COURSE COMPLETION: Completion of core through Bio 99 with a grade of B or higher, completion of Bio 194S Safety, consent of instructor. GRADE POINT AVERAGE: GPA 3.0 or higher TIME COMMITMENT PER WEEK: Minimum 20 hours per week. NUMBER OF UNITS REQUIRED: 5 OTHER: Accepts students that can work in the lab 20 hours per week spread over three days. Interested in students who will make at least a multi-quarter commitment (one to two years preferred). Currently six (6) positions available and routinely students needed on an on-going basis. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of Work and Weekly Meeting. OFFICE LOCATION: UCIMC, Building 55, 2nd Floor, Room 202. LOCATION OF RESEARCH: Hewitt Hall, Building 843, 2nd Floor.
Lbachir BenMohamed: firstname.lastname@example.org, (949) 824-8937
Rimal Bera, M.D. Psychiatry and Human Behavior
This research is takes place at UCIMC under the direct supervision of Dr. Bera. Students will join on-going clinical trials of both inpatients and outpatients who are enrolled in clinical research programs. These trials include medication evaluations, neuropsychological testing and retrospective medical record reviews. Students will be trained in psychiatric evaluation of multiple disease states and have the opportunity to work directly with 3rd and 4th year medical students and psychiatry residents with patients who are hospitalized. Students will get state of the art clinical contact with patients that will help them in future clinical opportunities. Independent research ideas to be studied will be encouraged. Presentation at scientific meetings along with submission of findings to scientific journals will be encouraged.REQUIREMENTS TO PARTICIPATE: Motivation and interest in direct patient contact in both clinical and research setting. COURSE COMPLETION: Minimum of 6 month committment GRADE POINT AVERAGE: Minimum GPA of 3.00 TIME COMMITMENT PER WEEK: 6 to 10 hours/week NUMBER OF UNITS REQUIRED: 3 to 4 units OTHER: FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Enthusiasm of effort and completion of assigned work.
Rimal Bera: email@example.com, (714) 456-6898
Hans-Ulrich Bernard, Ph.D. Molecular Biology & Biochemistry
RESEARCH DESCRIPTION: Induction of cervical carcinoma and other types of cancers by papillomaviruses. Specifically regulation of papillomavirus transcription during the normal life cycle and during carcinogenesis. REQUIREMENTS TO PARTICIPATE: Preferentially 3rd/4th year student, knowledge about transcription, virology, cell biology. COURSE COMPLETION: n/a GRADE POINT AVERAGE: n/a TIME COMMITMENT PER WEEK: minimum of 8 hours (1 full day or 2 half days) plus participation in group seminar (normally Wednesday at noon), preferentially for 2 or 3 quarters. NUMBER OF UNITS REQUIRED: n/a FACULTY MEANS OF EVALUATION FOR COURSE GRADE: enthusiasm and regular completion of committed time. OFFICE LOCATION: 114 Sprague Hall
Hans-Ulrich Bernard: firstname.lastname@example.org, (949) 824-5162
Michael W. Berns, Ph.D. Developmental & Cell Biology
The Cellular Biophotonics Laboratory of Professor Michael W. Berns is looking for an enthusiastic junior for a bio-199 position to join the cancer-aging telomere project. The goal of this project is to understand the effects of laser damage and study the different signaling pathways on telomeres. Students interested must hold a GPA of 3.5 or better, lab experience/course is a plus and must be interested in pursuing a career in the Health Sciences. A minimum of 12 hrs/week is required to join the lab. Please send your CV to Professor Michael W. Berns.
Michael Berns: email@example.com, (949) 824-6291
Bruce Blumberg, Ph.D. Developmental & Cell Biology, Pharmaceutical Sciences
RESEARCH DESCRIPTION: Our research focuses on the role of nuclear hormone receptors in embryonic development, adult physiology and human diseases such as obesity, cancer, inflammation and aging. Nuclear hormone receptors are ligand modulated transcription factors that directly regulate the expression of target genes. Students will gain experience in a broad range of research techniques including molecular biology, biochemistry, developmental biology, cell biology, cancer biology, molecular endocrinology, and genomics. Students beginning in summer and continuing through the year will be given preference, however, starting at any time in the academic year is possible for outstanding students if space is available. Students can visit the laboratory web site for more information. Previous students have published in major scientific journals and in the UCI Undergraduate Research Journal. Please contact Dr. Blumberg directly if you are interested. REQUIREMENTS TO PARTICIPATE: Generally speaking, completion of the first 2 years of the Bio Sci core is required. Exceptions have occasionally been made in the past for highly qualified and motivated students. COURSE COMPLETION: BioSci core through at least Bio 98. D103 and D104 are often helpful but not required. GRADE POINT AVERAGE: A GPA of 3.0 is required. TIME COMMITMENT PER WEEK: The nature of our research requires a time commitment of at least 20 hours per week for a minimum of one year. The possibility of a second year is advantageous as this will allow the student to undertake an independent research project. NUMBER OF UNITS REQUIRED: 5 OTHER: Students in the lab are strongly encouraged to participate in the Excellence in Research Program, the University Research Opportunity Program (UROP) and the Summer Undergraduate Research Program (SURP). FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality and quantity of work. LOCATION OF RESEARCH: 4351 Natural Sciences 2.
Bruce Blumberg: firstname.lastname@example.org, (949) 824-8573
Stephen Bondy, Ph.D. School of Medicine
The overall project goals are to understand how aging changes gene expression in the brain and how these changes may help explain the decline in neuroimmunological function associated with aging. We use lipopolysaccharide (LPS, a toxic, inflammatory stimulus of innate immunity) dosing, and exposure to a novel environment (behavior), as modulators the assess brain function in old mice compared to young. The project will determine the degree to which old mice express these genes differently than young, and how the expression pattern of the response to LPS differs in old mice. Expression changes of one gene, known to occur when animals are exposed to a novel environment, may also differ in the old mice that have also been challenged with LPS. The occurrence of another gene, previously undetected in brain and of unknown function there, will be confirmed, and its response to age, inflammatory challenge, and novel environment will be determined. The 199 Research will consist of extraction and purification of total RNA from previously-frozen mouse brains. Then expression levels of individual gene transcripts in the RNA samples will be measured by real time (quantitative) RT-PCR. A final aspect of the project is to summarize and prepare the results for poster presentation or publication.
Edward Sharman: email@example.com, (949) 824-4769
Daniela Bota, Neurology, Cancer Center
RESEARCH DESCRIPTION: 1. Translational Research: There is an unmet clinical need for the therapy of malignant gliomas with a median survival of <12 months despite available treatments. Traditional chemotherapy relays on DNA damage and disruption of mitotic machinery, with limited effect in prolonging patient survival. The focus of my research is to test novel agents, in an attempt to target downstream molecular mechanisms involved in tumor growth and resistance to apoptosis. The final goal is to provide scientific bases for clinical trials in patients with newly-diagnoses and recurrent malignant gliomas. 2. Clinical and Quality of Life Research: The main purpose of this study is to conduct a retrospective and prospective chart review to examine associations between care plan timelines and demographic variables in a large clinic sample of patients with brain tumors. Our research aims are to (1) compute correlations among the different variables and determine the average delay of care for Spanish speaking only patients versus native English speaking patients and (2) to test if a patient navigator can improve the access to care for brain tumor patients resulting in a decrease in time from diagnosis to treatment. REQUIREMENTS TO PARTICIPATE: Motivation and interest in conducting research in both clinical and laboratory setting. Prior laboratory experience desired for the translational research. COURSE COMPLETION: Minimum of 6 month commitment GRADE POINT AVERAGE: 3.4 TIME COMMITMENT PER WEEK: 15-20 hours/week NUMBER OF UNITS REQUIRED: 3 to 4 units OTHER: Would prefer at least 15-20 hours/week over 3 days every week. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Research presentation at the end of rotation, participation in lab meetings, commitment and professionalism. OFFICE LOCATION: UC Irvine Medical Center, Bldg 55, Room 121
Daniela Bota: firstname.lastname@example.org, (714) 456-7032
Matthew Brenner, M.D. Medicine/Beckman Laser Institute
The laboratory performs translational research to investigate the potential clinical uses of two new technologies: 1) optical coherence tomography (OCT) for diagnosis and management of airway cancer and toxic inhalation injury, and 2) diffuse optical spectroscopy (DOS) for the real time assessment of tissue oxygenation and other relevant physiological parameters in critical care monitoring. REQUIREMENTS TO PARTICIPATE: Biological Sciences/Biomedical Engineering or related students. GRADE POINT AVERAGE: 3.5 TIME COMMITMENT PER WEEK: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Evaluation will be made based on student’s reliability and enthusiasm, as well as their completion of reading assignments, literature searches and help in design and completion of research activities.
Adriana Briscoe, Ph.D. Ecology and Evolutionary Biology
RESEARCH DESCRIPTION: Research positions are available to work on a number of projects related to studying the evolution and functional characterization of opsin genes in butterflies. Students will have the opportunity to learn molecular biological techniques such as PCR, cloning and sequencing, and after such techniques are mastered, will be encouraged to develop an independent project in their second year. Minimum requirements are at least a 1 year commitment, 3 units (9 hours/week) per quarter, mandatory lab meeting attendance and a G.P.A. of 3.3+. GRADE POINT AVERAGE: 3.3+ TIME COMMITMENT PER WEEK: 9-12 hours/week NUMBER OF UNITS REQUIRED: 3 OTHER: Mandatory lab attendance, written summary of research progress at the end of each quarter. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Successful acquisition of experimental data and lab meeting attendance. OFFICE LOCATION: MH5248
Adriana Briscoe: email@example.com, (949) 824-1118
Donald J. Brown, Ophthalmology
RESEARCH DESCRIPTION: Primary open angle glaucoma (POAG) represents a serious and growing health problem accounting for ~12% of global blindness. Studies have identified age, ancestral group (racial background), and intra-ocular pressure (IOP) as significant risk factors for the development and progression of POAG. The objective of our research is to define the 3 dimensional biomechanical properties of the optic nerve head (ONH ) by microscopically reconstructing the structural components and biomechanical properties and relate these properties to POAG risk factors. In our lab, state of the art technologies to globally assess the three dimensional structure and mechanical properties of the ONH are used. These technologies utilize non-linear optical affects that occur when photons generated by ultrafast lasers interact with tissue and include: 1) two photon excited fluorescence (TPEF), and 2) second harmonic generation (SHG). SHG and TPEF allow us to selectively and specifically visualize and quantify collagen (SHG) and elastic fibers (TPEF) within the 3D space of unfixed and unstained ONH tissue. This allows direct study of the effects of pressure on the structural organization of the ONH and LC. Additionally, semi-automated array tomography is used to 3 dimensionally reconstruct the entire ONH at high resolution and volumetrically measure the collagen and elastin distribution and content within the LC. REQUIREMENTS TO PARTICIPATE: General biology, physics, and a willingness to learn COURSE COMPLETION: GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: minimum 4 hours NUMBER OF UNITS REQUIRED: FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Laboratory notebook, participation in lab meetings/discussions, participation in UROP undergraduate research day. OFFICE LOCATION: Orange Campus, Bldg 55, room 208. LOCATION OF RESEARCH: Hewitt Hall, Building 843, 2nd Floor.
Donald Brown: firstname.lastname@example.org, (949) 824-8936
Peter Bryant, Developmental & Cell Biology
Project 1). Asymmetric Division of Neural Stem Cells. Study the mechanisms of cell division in mammalian neural stem cells, using a rat model of Parkinson’s Disease or stroke. Test the hypothesis that these cells undergo asymmetric cell division, by immunostaining and confocal microscopy using antibodies against the human homologs of asymmetric cell division determinants identified genetically in Drosophila. REQUIREMENTS TO PARTICIPATE: • Interest in stem cell biology • 2-page proposal during the first two weeks • 5-page report due at the end of Finals Week. • 4 units of work (12 hours/wk). 3.5 GPA. Project 2). Monitoring Local Biodiversity. Work with the faculty advisor and other local experts to document and monitor local wildlife populations, choosing from one of the following: • Photo-documentation of local species of invertebrates (mainly insects and spiders), field studies of their distribution, seasonality and abundance, and contribution to a web site showing the life history, interesting features, and conservation issues concerning each species. • Bird counts at Upper Newport Bay and/or the San Joaquin Wildlife Sanctuary • Marine Life Inventory at Upper Newport Bay REQUIREMENTS TO PARTICIPATE: • Some knowledge of or at least interest in local natural history. • Willing to do unsupervised field work after training is completed. • Field work may require the student to obtain or rent equipment (binoculars, spotting scope, camera) and obtain a field guide. • 2-page proposal during the first two weeks • 5-page report due at the end of Finals Week. • 4 units of work (12 hours/wk). 3.5 GPA. Project 3). Campus Sustainability. Investigate the operation of the UCI campus to identify activities that can be made more independent and sustainable, and initiate student action to make improvements. Projects include use and reuse of energy and water, use of drought-resistant native plants, minimizing waste, use of biodegradable materials in food facilities, general recycling and waste reduction projects, and pollution-free transport. Methods include library and internet research, interviews with campus decision-makers, and comparison with other campuses followed by practical participation and promotional activities for improvements through student organizations. Projects will be supervised by the faculty advisor and the UCI Recycling Coordinator. REQUIREMENTS TO PARTICIPATE: • Willingness to carry out research as well as practical work at the campus recycling center. • 2-page proposal during the first two weeks • 5-page report due at the end of Finals Week. • 4 units of work (12 hours/wk). 3.5 GPA.
Peter Bryant: email@example.com, (949) 824-4714
William Bunney, M.D. Psychiatry and Human Behavior,
TWO PROJECTS: Project #1 — Contact Julie Patterson, Ph.D., at (714) 456-1663 or firstname.lastname@example.org — UCI Medical Center – This research is using brain function (electroencephalogram or EEG), neuropsychological (tests of memory, attention, reaction time, etc.), symptom, and clinical interview measures to study the contribution of brain inhibitory mechanisms and information processing deficits to the symptoms of schizophrenia and bipolar disorder (manic depression). The students will have the opportunity to have direct patient contact by helping with patient interviews and testing. The research is done at the UCI Medical Center. Students are needed on an ongoing basis.——————————————— Project #2 — Contact David Walsh, PsyD, ABPP, at (949) 824-5013, RESEARCH DESCRIPTION: UCI Main Campus – This project is funded by the National Institute of Mental Health to examine genetic, architectural, and biochemical brain abnormalities in major depression, bipolar affective disorder and schizophrenia. This opportunity would be appropriate for students interested in research of severe mental illnesses. Students would develop a clear understanding of DSM-IV diagnostic criteria, risk factors for suicide and general research methodology. Students are needed on an ongoing basis. REQUIREMENTS TO PARTICIPATE: Motivation and interest in clinical research. GRADE POINT AVERAGE: Minimum GPA of 3.00 TIME COMMITMENT PER WEEK: 6 to 10 hours per week FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Enthusiasm of effort and completion of assigned work. OFFICE LOCATION: Main Campus – 5251 California Ave, Suite 160, Irvine, CA REQUIREMENTS TO PARTICIPATE: Interest in clinical research. TIME COMMITMENT PER WEEK: A minimum of 6 hours per week (2 units) is preferred. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality and quantity of work.
Jorge Busciglio, Ph.D. Neurobiology
Opportunity for 199 students to participate in ongoing research on the molecular bases of neuronal dysfunction and death in Down’s syndrome (DS) and Alzheimer’s disease (AD). Our research focuses on three areas: 1- Cellular and molecular correlates of mental retardation and progression of AD in DS, including the role of mitochondrial dysfunction and oxidative stress in the disease process; 2- Molecular mechanisms of Aß synaptotoxicity; and 3- Axonal transport deficits in DS and AD neuropathology. Specific training: Trainees gain experience in cell culture methods, image analysis, molecular biology, and biochemistry. Requirements: Sophomore or Junior standing, 3.4 GPA (this may be negotiable). Minimum commitment of 1 year (4 quarters), 2 years preferred. Dedication of at least 10-12 hours per week is required. Evaluation and grades are based on student’s reliability, enthusiasm and completion of research activities.
Jorge Busciglio: email@example.com, (949) 824-9075
Vincent Caiozzo, Ph.D. Physiology & Orthopedic Surgery
Sophomore standing or higher. Studying hibernating muscle physiology & disuse atrophy in several non-model species, including ground-squirrels, bears, bats and marmots. Examining lizard species as well. Utilization of several molecular biology techniques. Involves analyzing the protein and mRNA profiles of myosin in muscle, using RT-PCR and SDS-PAGE. Cloning myosin genes in the above species. Summer work may involve some travel to collect samples from collaborating institutions ( Colorado and the Sierra Nevada , CA).
Bryan Rourke: firstname.lastname@example.org, (949) 824-5571
Anne L. Calof, Ph.D. Anatomy & Neurobiology, Developmental & Cell Biology
199 students are needed to participate in ongoing research on neural stem cells and molecular signals that regulate development and regeneration of the nervous system. Successful 199 students from the laboratory frequently become authors on papers published in scientific journals, and may have the opportunity to present their research at national conferences. Requirements : Minimum Sophomore (for exceptional cases) or Junior standing, 3.4 GPA (this is sometimes negotiable), Minimum commitment 1 year (4 quarters), 2 years preferred, willingness to perform 1 st quarter Pass/no pass basis to learn lab techniques, must spend 8-12 hours per week, attend weekly lab meetings and present research in lab meetings.
Anne Calof: email@example.com, (949) 824-5745
Diane R. Campbell, Ph.D. Ecology & Evo Biology
Research in my lab concern the mechanisms of evolution in natural plant populations. Current projects focus on plant hybrid zones. We are comparing the fitness of plant hybrids to that of the parental species to test particular models for genetic differentiation and evolution of new species. Approaches include experimental field studies in the Colorado Rockies and the eastern Sierras. These involve measurement of insect and bird pollinator behavior, pollination success, photosynthetic and other physiological traits, and seed production in common gardens. At UCI we do greenhouse studies of floral and physiological traits, and DNA analyses to examine the genetic structure of natural hybrid zones. Students with strong interest in ecology, genetics, and/or evolution. Bio 93 and 94, or Bio 96 required. Bio 97 and E106 are helpful. Minimum 3.2 GPA. 6-12 hours/ wk. 2-4 units required.
Diane Campbell: firstname.lastname@example.org, (949) 824-2242
Maxime Cannesson, M.D. Anesthesiology and Perioperative Care
RESEARCH DESCRIPTION: In the department of Anesthesiology & Perioperative Care at UCI we will analyze clinical data of current and past surgical patients to aid us in making quality improvements in standard patient care, perioperative and postoperative outcomes. We will gather clinical data to better understand hemodynamics and other factors which impact patient outcomes. REQUIREMENTS TO PARTICIPATE: Must be able to collect data at UC Irvine Medical Center (Orange, CA), be in good educational standing, and meet all course pre-requisites. TIME COMMITMENT PER WEEK: 5-12 hours per week NUMBER OF UNITS REQUIRED: 1-3 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Students will work under the direction of the principle investigator (Dr. Cannesson) and the director of clinical research (Cecilia Canales) for the department of Anesthesiology and Perioperative Care. Students will be evaluated based on their ability to learn from and contribute to data collection, literature searches, abstract development, and interactions with clinical faculty and staff, and patients. Students will be required to review and summarize relevant literature. LOCATION OF RESEARCH: UC Irvine Medical Center.
Cecilia Canales: email@example.com, (714) 456-8998
F. Lynn Carpenter, Ph.D. Ecology
Sophomore standing and above. Completion of Bio. 94. I am investigating methods to reforest eroded, nutrient-deficient, toxic tropical soils where rainforest was cut for pasture 50 years ago, and the land severely overgrazed. We have many long term experiments in Costa Rica on regeneration of forest and of topsoils. Students may participate in my 199 program either by analyzing one of these ongoing experiments or by establishing their own experiment in the field in Costa Rica . Examples of potential topics include the role of soil biology and chemistry in tree growth, the characteristics of trees capable of growing in eroded soil, and the repopulation of reforested areas by birds and insects. Two quarters of preparatory research are required if a student wishes to work with us in Costa Rica in the summer. Details of our various research approaches are on the website
Lynn Carpenter: firstname.lastname@example.org, (949) 824-2556
Philip M. Carpenter, M.D. Pathology
RESEARCH DESCRIPTION: Our interest is how normal tissues contribute to the metastasis (spread through out the body) of breast and other cancers. We have identified a basement membrane protein, laminin 5 that is secreted by normal breast cells, yet causes increased migration and spread of breast cancer cells. REQUIREMENTS TO PARTICIPATE: One quarter of biochemistry lab or cell biology is preferred. COURSE COMPLETION: 1 year biology, biology lab and general chemistry, at least 1 quarter of organic chemistry. Recommendation from your lab instructor is required. GRADE POINT AVERAGE: GPA: B or better TIME COMMITMENT PER WEEK: 12 hours minimum, at least 4 days out of the 5 day week, 15-18 preferred. NUMBER OF UNITS REQUIRED: 3 units will be given for 12 hours work. OTHER: The lab is at UCI Medical Center in Orange, (not on campus or at the Medical School), so students should be prepared to commute by car or shuttle bus and comply with additional UCIMC requirements. Inquiries must be received 1 month before the beginning of the quarter. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Participation is most important, and a write up pertaining to the research will be assigned each quarter. LOCATION OF RESEARCH: UCIMC, Orange, CA.
Philip Carpenter: email@example.com, (714) 456-6141
Paolo Casali, M.D. Director, Institute for Immunology Medicine
Research in Dr. Casali’s lab is to address fundamental questions in molecular biology, cell biology and immunology, including those highly relevant to immunity against infections, development of autoimmune diseases or cancer. It investigates the mechanisms of class switch DNA recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes using cutting-edge in vivo and in vitro approaches. Casali lab has made key contributions to the understanding of mechanisms that underlying the targeting of the CSR machinery, including the recent discovery that 14-3-3 adaptors and Rev1 DNA polymerase play scaffolding functions in stabilizing CSR factors on DNA. Casali lab is also undertaking exciting projects towards a much better understanding of the epigenetic mechanisms underlying the antibody and autoantibody responses. Students will be trained in a variety of basic and advanced molecular and cellular biology techniques, such as: aseptic technique, cell culture protocols, DNA and RNA isolation, cDNA synthesis, flow cytometry, molecular cloning, PCR, real-time quantitative qPCR, PAGE, Western, Southern and Northern blotting, EMSA, and ELISA. Work involves human lymphocytes and/or transgenic and knockout mice. Interested students should submit an updated resume with relevant research experience. Students will be assigned to specific projects based on the commitment and enthusiasm of the student to lab work. Interested students are encouraged to visit the lab prior to requesting a position. Minimum GPA of 3.0 and 16 hours/week of time commitment are required. In order to be considered for a Bio199 position, please send a completed application, including the application form (available at http://casalilab.immunology.uci.edu/_var/application.doc), your CV and transcripts, to Dr. Casali through email (firstname.lastname@example.org). Lab website: casalilab.bio.uci.edu Lab Blog: http://casalilab.immunology.uci.edu/blog.ph REQUIREMENTS TO PARTICIPATE: Minimum GPA 3.0 COURSE COMPLETION: GRADE POINT AVERAGE: at least 3.0 TIME COMMITMENT PER WEEK: 16 hours NUMBER OF UNITS REQUIRED: at least 2 OTHER: FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Attendance, diligence and hard work.
Jack Xu: email@example.com, (949) 824-0193
Thomas Cesario, School of Medicine
The use of foreign antibodies for the treatment of several diseases in humans The use of specific antibodies to treat disease is of growing importance, especially for the treatment of cancer, neurological diseases, and infectious diseases. Unfortunately, the source of these antibodies is very limited since the patient has to be treated with the same antibody several times. Antibodies produced in animals are limited to a single use, as subsequent administration of the same antibodies will induce a harmful immune respone (e.g. allergic reaction) and can lead even to death. Additonal antibodies derived from animals is viewed as foreign by the human body and can elicit an antibody reaction on its own and be eliminated before having an effect. Methods for rendering these proteins safe for multiple injections and keep the antibodies functionell are being actively researched including production of hybrid monoclonal antibodies and the “humanized” animals. However, many of these methods are time consuming , expensive and complicated, and mostly specific for only one disease. We developed a new technology to make these proteins from animals safe for multiple injection, and this methode is less time consuming, less expensive and not very complicated, and it is not disease specific. Currently we want to evaluate our new technique to determine if we are able to use these antibodies for treating diseases such as infectious diseases and autoimmune diseases. Therefore, we are looking for students who are interested in immunology and infectious diseases. The students will be involved in immunological techniques such as ELISA and Westernblot and molecular biological techniques such as cloning, polymerase chain reaction , and tissue culture and also in handling the animals. Recent studies from a private Laboratory (PlasVacc USA, Templeton, CA), however, suggested that mice will tolerate multiple injections of a modified technique to produce cryoprecipitate-depleted plasma (Cryoprecipitate is a precipitate that forms when normal blood plasma is cooled, and is especially rich on clotting factors-the remaining plasma contains the antibodies). The plasma obtained with this improved technique is now termed cryoprecipitate-FREE plasma. THE DIFFERENCE BETWEEN CRYOPRECIPITATE-FREE PLASMA OR DEPLETED PLASMA IS THE AMOUNT OF THE CRYOPRECIPITATE ASSOCIATE PROTEINS. CRYOPRECIPITATE CONTAINS TYPICALLY 40% OF THE PROTEINS PRESENT IN THE PLASMA; THE REMAINING 60% ARE STILL IN THE PLASMA WHICH IS TERMED CRYOPRECIPITATE-DEPLETED PLASMA. THE CRYOPRECIPITATE-FREE PLASMA IS FREE OF CRYOPRECIPITATE ASSOCIATE PROTEINS. The mice survived three immunization with the cryoprecipitate-FREE plasma after the plasma was sterilized over a column (personal communication-see attachment). However, this company never tested, if the antibodies are still functional. Therefore, we wish to perform a study to test the hypothesis that cryoprecipitate-free plasma is 1) tolerated by animals from a different species by repeated injections and 2) the antibodies in this plasma are still functional. We will use rabbits as the plasma donors, and mice as the test subjects.
Martina Berger: firstname.lastname@example.org, (714) 456-5161
Jeff Chan, Ph.D. Pathology, Biological Chemistry, Toxicology
RESEARCH DESCRIPTION: Cell growth and function require the coordinate regulation of gene expression by transcription factos. My lab seeks to understand the role of CNC-bZIP transcription factors in cellular stress response. Diverse molecular and genetic approaches are being applied to delineate the physiological roles of CNC factors in cell function; their roles in maintaining cellular homeostasis and the genesis of cancer and other diseases; and the mechanisms by which these factors function. GRADE POINT AVERAGE: 3.3 or better TIME COMMITMENT PER WEEK: 12-15 NUMBER OF UNITS REQUIRED: 3 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Performance, quality of work
Jeff Chan: email@example.com, (949) 824-9605
George Chandy, Ph.D. Physiology & Biophysics
Our lab studies the relationship between specialized membrane proteins, potassium channels, and disease. One of the channels we are interested in, Kv1.3, is a voltage gated channel which is upregulated in fully differentiated autoreactive T-cells. We are currently developing channel blockers for Kv1.3 as therapeutics for autoimmune disease (multiple sclerosis, type I diabetes, and rheumatoid arthritis). The second potassium channel that we study, the SK channel, is implicated in several neurological disorders and also hypertension. We have generated a transgenic mouse in which this channel’s function has been silenced in dopaminergic neurons. We believe that this mouse has the potential to act as a model for ADHD (attention deficit hyperactivity disorder), drug addiction, and also hypertension. We are looking for responsible students with a GPA of at least 3.0 to carry out work in one of these areas. All of our available projects have direct clinical implications, and students will gain experience in understanding how a single class of molecules can lead to disease. We have had previous 199 students that have gone on to medical schools and top graduate programs in the biological sciences.
George Chandy: firstname.lastname@example.org, (949) 824-7435
Dongbao Chen, Ph.D. Obstetrics and Gynecology
RESEARCH DESCRIPTION: Cellular and molecular mechanisms underlying hormone and growth factor regulation of vasodilatation and angiogenesis at the maternal, fetal and placental interface with focuses on reactive nitrogen and oxygen species. REQUIREMENTS TO PARTICIPATE: Sophomore and up COURSE COMPLETION: N/A GRADE POINT AVERAGE: GPA >3.5 TIME COMMITMENT PER WEEK: 12-16 NUMBER OF UNITS REQUIRED: 3-4 OTHER: Basic lab safety trainings FACULTY MEANS OF EVALUATION FOR COURSE GRADE: 1. Attendance 2. Experimental lab notes 3. Lab meeting presentations (2-3 times per q quarter). OFFICE LOCATION: Med Surge I, Build 810, Rm 140
Dongbao Chen: email@example.com, (949) 824-2409
Phang-Lang Chen, Ph.D. Biological Chemistry
RESEARCH DESCRIPTION: The central theme of my research is to elucidate the fundamental mechanisms governing genome integrity with specific emphasis on the intracellular signaling pathways involved in the DNA damage response and repair. Currently we focus on dissecting DNA surveillance mechanisms. Diverse molecular and genetic approaches using mammalian cell culture and yeast are being applied to delineate the DNA checkpoint factors in cell function; their role in DNA damage responses and repair. COURSE COMPLETION: Cell Biology, Genetics, Molecular Biology, Biochemistry, GRADE POINT AVERAGE: GPA 3.0 or higher TIME COMMITMENT PER WEEK: at least 12 hrs of work NUMBER OF UNITS REQUIRED: at least 3 units OTHER: one-year commitment. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Students will be graded based on their performance and given a numeric number of A through F. LOCATION OF RESEARCH: Med Sci 1, Room D268
Phang-Lang Chen: firstname.lastname@example.org, (949) 824-4008
Ken Cho, PhD Developmental and Cell Biology
RESEARCH DESCRIPTION: In our laboratory we are interested in understanding growth factor signaling in early vertebrate embryogenesis. Using functional genomics along with molecular biology, we are investigating the morphological regulation of tumor growth factor-β (TGFβ) signaling in Xenopus and Mouse. Particularly, work for this project will contribute to elucidation of BMP signaling in pre and post implantation stages of mouse embryos. REQUIREMENTS TO PARTICIPATE: Applicant should have completed the first two years of Bio Sci Core courses. Preference will be given to junior students. COURSE COMPLETION: It is helpful if the applicant has completed D103 or D104, but not required. GRADE POINT AVERAGE: 3.0 GPA and higher TIME COMMITMENT PER WEEK: Minimum of 15 hours per week. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality and quantity of work.
Dr. Ken Cho: email@example.com, (949) 824-7950
Bernard Choi, Ph.D. Biomedical Engineering and Surgery, (Beckman Laser Institute)
RESEARCH DESCRIPTION: The mission of the Choi Microvascular Therapeutics & Imaging (MTI) Lab is to develop instrumentation and employ methods to improve in vivo characterization of the microvasculature. 199 students in my laboratory work in a multidisciplinary environment at the intersection of engineering, vascular biology, and clinical medicine. I strongly encourage independent research projects which encompass at least one (oftentimes several) of the following topics: 1. Optical imaging instrument development/characterization 2. Animal surgery 3. Clinical research 4. Light-based therapy monitoring 5. Computational modeling The most updated list of research opportunities can be viewed at the MTI lab website: http://choi.bli.uci.edu/ REQUIREMENTS TO PARTICIPATE: Requirements vary by project. I am most interested in students who have at least two years to commit to research in my lab. COURSE COMPLETION: Course requirements vary by project. GRADE POINT AVERAGE: >3.5 GPA is desired. TIME COMMITMENT PER WEEK: >8 hrs/week NUMBER OF UNITS REQUIRED: >2 OTHER: N/A FACULTY MEANS OF EVALUATION FOR COURSE GRADE: I evaluate productivity and effort, and ability to integrate into the existing MTI lab framework. OFFICE LOCATION: Beckman Laser Institute
Bernard Choi: firstname.lastname@example.org, (949) 824-9491
Olivier Cinquin, Ph.D. Developmental & Cell Biology
RESEARCH DESCRIPTION: Multicellular organisms have evolved a great variety of cell types that perform specialized functions. Stem cell progeny that are destined to differentiate proliferate transiently and choose one of those cell types. This differentiation process, of great spatial and temporal precision, is at the heart of development and organ homeostasis. How differentiation is controlled is thus a question of tremendous importance from scientific and therapeutic standpoints. Although much progress has been made over the last century, a major stumbling block has appeared in the form of the complexity of the regulatory networks controlling differentiation. One of our approaches is to start from a fecund, simple model organ whose regulation has been extensively characterized at the genetic and biochemical levels: the C. elegans germ line. We ask how the current knowledge of regulatory parts all fits together to explain organ-level behavior. We perform experiments that target organ-level behavior of the germ line, rather than individual genes in the regulatory network. Guided by these experiments, and building on knowledge generated by many labs over the past 30 years, we use mathematical and computational methods to analyze how the regulatory network accounts for organ-level control of cell proliferation and differentiation. TIME COMMITMENT PER WEEK: 16 hours NUMBER OF UNITS REQUIRED: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: 50% two page report summarizing the experiment, data gathered and conclusions. 50% quality of the experiments. LOCATION OF RESEARCH: 4103 McGaugh Hall
Olivier Cinquin: email@example.com, (949) 824-9822
Olivier Civelli, Ph.D. Pharmacology
RESEARCH DESCRIPTION: Areas of research: molecular pharmacology, neurobiology, drug discovery. Central theme: discover novel neurotransmitters involved in brain disorders and discover drugs found in traditional Chinese medicines. Disorders currently studied: schizophrenia, obesity, drug addiction, pain, sleep disorders, stress. Students will have opportunity to participate in experiments covering all aspects of pharmacological research: molecular (cloning) and cellular (cell culture) biology, pharmacology (binding and second messenger assays) and animal behavior (if desired). REQUIREMENTS TO PARTICIPATE: students interested in pharmacological/pharmaceutical research; commitment: 2 years or more. Preference to those with experience in biological and/or chemical techniques. GRADE POINT AVERAGE: 3.3+ TIME COMMITMENT PER WEEK: 12-16 hours/week NUMBER OF UNITS REQUIRED: 3 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: participation, willingness to learn, responsibility OFFICE LOCATION: 369 Med Surge II, School of Medicine
Olivier Civelli: firstname.lastname@example.org, (949) 824-2522
Susana Cohen-Cory, Ph.D. Neurobiology
Laboratory based research investigating mechanisms of neuronal development, with particular emphasis in the use of embryological and microscopy imaging techniques. Requirements: Bio. Majors and completion of freshman year that includes 1 yr. of general chem with labs, Bio Sci 93, and Bio Sci 94.
Susana Cohen: email@example.com, (949) 824-8188
Dan Cooper, M.D. Pediatrics, ICTS
2 RESEARCH DESCRIPTIONS: 1) Mentorship with Dr. Cooper: Premature birth is recognized as the single most important health problem in maternal child health in the US. Paradoxically, both failure to thrive and obesity are now known to be associated with prematurity, as are osteopenia (a condition where bone mineral density is lower than normal) and increased risk of fracture, and increased risk of cardiovascular disease later in life. We lack cohesive approaches to mitigate these profound threats to health. Despite promising new research demonstrating that physical activity can stimulate the growth of muscle and bone even during intrauterine life (perhaps through metabolic programming), there have been very few attempts to implement and study physical activity interventions in the premature baby. We are currently recruiting for a NIH funded study which exams the effects of a novel intervention program designed to increase physical activity of premature babies in their first year of life. The intervention has been designed and pilot tested–one that engages the caregiver as a partner. Using techniques and tools as far-ranging as DXA, smart phones, doubly labeled water, and lightweight, wireless accelerometers developed specifically for this purpose, the working hypothesis is that the one-year intervention will augment lean body mass (primary outcome variable) and improve bone mineralization and the ratio of lean to fat tissue (secondary outcome variables The potential beneficial impact of augmented physical activity on 1) Body composition 2) Associated biochemical and cellular mechanisms of growth and inflammation 3) Quality of maternal care will be measured. REQUIREMENTS TO PARTICIPATE: Attend Monday laboratory meetings from 10-11:30 AM. COURSE COMPLETION: 194S. Sophomore standing and up only please. GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: 8-15 hours/week. We prefer a 1 year commitment. NUMBER OF UNITS REQUIRED: 2-4 OTHER: Students will be working in the UCI Douglas Hospital Neonatal Intensive Care Unit as well as accompanying study personal to participant homes. We are particularly interested in Spanish-speaking and Vietnamese-speaking students who can assist with recruitment and enrollment of non-English speaking participants. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Reliability, ability to communicate and quality of work. We would like our students to apply for UROP grants and present at the symposium. LOCATION OF RESEARCH: UCI Douglas Hospital Neonatal Intensive Care Unit. Contact: Jessica Vaughan at firstname.lastname@example.org or (714) 456-6589.
Carl Cotman, Ph.D. Neurobiology & Behavior
Assist in neurobiological studies comparing normal and abnormal brain aging (both animal and human). The primary focus will be using an animal model of human brain aging. The student will be involved with experiments that use techniques such as immunocytochemistry, immunofluorescence, confocal microscopy, Western blotting and ELISAs on brain tissue. The student will compare animals treated with antioxidants to those without to see if there is a reduction in brain pathology. Parallel studies involving human brain tissue (Alzheimer’s disease and normal aged controls) will also be included as the student acquires the necessary skills.
Carl Cotman: email@example.com, (949) 824-5847
Karina S. Cramer, Ph.D. Neurobiology
Research is on how specific connections are formed in the brain during development and plasticity. Focus is on the auditory brainstem, where much is known about the connectivity and its importance for brain function. The lab has been examining the role of a family of proteins called the Eph receptors, and their ligands, the ephrins. Lab uses immunohistochemistry, in situ hybridization, and western blots to analyze gene expression. Lab also uses a variety of gene misexpression techniques followed by axon tracing methods to test roles for these proteins. Requirements: completion of Bio110, minimum GPA of 3.0. Must be interested in lab research and motivated to complete an independent project. 3 – 5 units, 10 – 20 hours per week.
Karina Cramer: firstname.lastname@example.org, (949) 824-4211
Steven C. Cramer, Neurology
RESEARCH DESCRIPTION: Project 1: Genetics of Cortical Plasticity. Participation will prepare students for improved understanding of the human brain, how it functions, and how genes and experience affect the plasticity of these functions. Students will be involved in research examining how genetic factors influence cortical plasticity in healthy human subjects as well as clinical populations. Main duties will include assisting with the following: performance of brain mapping such as transcranial magnetic stimulation, performance of subject assessments, analysis of brain mapping data such as functional magnetic resonance imaging, analysis of electromyograms, and statistical analyses of behavioral data. Project 2: Robotic Therapy. Participation will prepare students for an improved understanding of the human brain, how it functions and the factors that influence plasticity of these functions. Students will participate in the research process of a robotic study focused on arm motor recovery after stroke. Main duties may include assisting with the following: analysis of brain mapping data from subject functional magnetic resonance imaging and transcranial magnetic stimulation, electromyogram analysis, statistical analyses of behavioral and robot data, and/or subject assessments and robot therapy. Project 3: Brain Function In The Early Days After Stroke. Participation will prepare students for an improved understanding of the human brain, and how it is affected by a new stroke. Students will participate in a research project that follows patients through their hospitalization for acute stroke. Assessments will include MRI, electroencephalography, behavioral testing, genetic testing, and more. Main duties may include assisting with the following: analysis of MRI and electroencephalography data, review of medical charts to extract data, statistical analyses, and/or patient examination. REQUIREMENTS TO PARTICIPATE: Commitment to participate for at least 2 years. COURSE COMPLETION: Bio 194S. GRADE POINT AVERAGE: 3.0 + TIME COMMITMENT PER WEEK: 6-10 hours per week (flexible) NUMBER OF UNITS REQUIRED: 3+. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Course grade based on caliber of performance and participation in lab journal club. OFFICE LOCATION: Hewitt Hall, Room 1331.
Steven Cramer: email@example.com, (714) 456-6876
David Cribbs, Neurology & Institute for Brain Aging and Dementia
My research interests are in the degenerative mechanisms that contribute to the onset and progression of Alzheimer’s disease (AD), and the development of novel therapeutic strategies to treat the disease. My laboratory is currently focused on immunotherapy (Aβ-vaccine) as an experimental approach to test the Beta-Amyloid (Aβ) Cascade Hypothesis of AD and as a potential intervention for treating patients suffering from the disease. I utilize transgenic (Tg) mouse models that overexpress human mutant forms of the Amyloid Precursor Protein (APP/Tg). These mice develop extensive AD-like Aβplaque pathology in the brain as they age. Thus, they provide a valuable experimental platform for testing hypotheses on disease mechanisms, as well as potential therapeutic and prophylactic approaches. When the APP/Tg mice are immunized with Aβ peptide, the B cell epitope of Aβ induces antibodies that bind to Aβ, which fafilitates clearance of the peptide from the brain. However, because Aβis a self-antigen it is necessary to break the immune tolerance to self, thus the current immunization protocols rely on very powerful adjuvant systems. Unfortunately, the first clinical trial on AD patients (AN1792) was halted when approximately 6% of the participants developed an adverse inflammatory response in their brains (meningoencephalitis). Speculation on putative culprits for the failure of the clinical trial include the adjuvant (QS21) used to boost the immune response in the elderly patients, and the Aβ “self” T cell epitope. QS21 induced a strongly proinflammatory T cell-mediated (Th1) immune response specific to the Aβ self T cell epitope. Additional factors that may have contributed to the adverse events in the elderly patients that received the vaccine include the level of vascular pathology, changes in blood brain barrier permeability induced by immunization, and the effects of aging on the immune response to Aβ-immunotherapy. My laboratory is developing mouse models that replicate the adverse events that occurred with the AN1792 clinical trial. These mouse models will be used to test the safety of “second generation” vaccines that incorporate alternative strategies for inducing the therapeutic anti- Aβ antibodies without inducing strong Th1 responses. The new vaccine candidates contain “molecular adjuvants” that can amplify the humoral (antibody) response while attenuating the potentially dangerous cell-mediated immune response against Aβ. These include both peptide based and DNA based immunization strategies that include components of the complement system, innate immune system and cytokines in order to enhance antigen presentation and to polarize the immune response toward a Th2 phenotype. New pre-clinical trials in APP/Tg mice are critical for gaining a better understanding of the potential benefits, as well as, the risks associated with Aβ-immunotherapy as a strategy for treating AD patients. Students must be interested in laboratory research and motivated to complete an independent project. Research involves animal handling, behavioral testing, blood and solid tissue collection, fixation and staining of brain tissue and characterization of neuropathology. Students will also participate in vaccinating mice, analyzing serum by ELISA for antibodies against the beta-amyloid peptide. Interested students should submit an updated resume along with a list of completed chemistry, biology and neuroscience courses. Project assignments will be determined by the commitment and enthusiasm of the student for lab work. Interested students are encouraged to visit the lab prior to requesting a position. Minimum requirements: 1) GPA of at least 3.0 2) Minimum commitment 1 year (4 quarters), 2 years preferred. 3) Must commit to work 8-12 hours per week, attend weekly lab meetings and present their research results during lab meetings. In addition, previous lab experience and competence with Photoshop, PowerPoint, Excel and statistical analysis are desirable. The quality of laboratory work, lab meeting presentations and a quarterly paper on research results will figure eqully in the grade evaluation for the 199 students.
David Cribbs: firstname.lastname@example.org, (949) 824-3482
Brian Cummings, Ph.D. Physical Medicine & Rehabilitation
RESEARCH DESCRIPTION: Dr. Cummings in an Associate Professor in the Departments of Physical Medicine & Rehabilitation, Institute for Memory Impairments and Neurological Disorders and Anatomy & Neurobiology. His laboratory investigates the characterization of ES, iPS, and adult neural stem cell lines for use as therapeutics by studying the interactions between human neural stem cells and the injured CNS using in vitro and in vivo models of spinal cord injury, traumatic brain injury, and neurodegeneration. One focus is the effect of the injured microenvironment on stem cell survival, differentiation, and engraftment. These experiments entail microsurgery, behavioral analysis, immunocytochemistry, stereological quantification of survival and fate, and electron microscopy. His laboratory has demonstrated that human neural stem cells differentiate into neurons, which form synaptic connections with an injured mouse host and oligodendrocytes, which remyelinate mouse axons. Subsequent behavioral improvements are abolished following selective ablation of engrafted human cells, demonstrating that human neural stem cells functionally integrate with their host and form meaningful connections (Cummings et al., PNAS, 2005, Hooshmand et al, PLoS One 2009). Cell-based therapeutic approaches are dependent upon immunosuppression in an otherwise normal animal or testing for proof of principal in immunodeficient models. This has significant implications for animal experiments and for human trials, where continuous immunosuppression may be required to obtain successful graft survival. Little is known about the direct effects of immunosuppressant drugs on neural stem cell proliferation or differentiation. His lab is currently examining the effects of immunosuppressants on human stem cell survival, proliferation and fate, as well as the interaction between cells of the immune system and stem cells. The lab is currently working with human embryonic stem cells (H9, HUES9 and Shef-3, Shef-4 and Shef-6), human amnion derived stem cells (from Stemnion LLC), and fetal derived neural stem cells (StemCells Inc). A new area of study focuses on the epigenetic changes that occur as cells are cultured or transitioned to xenofree (animal free) media conditions or exposed to biomaterials. REQUIREMENTS TO PARTICIPATE: Attendance of Lab Meetings at least 1 qtr per year Completion of assigned lab safety training COURSE COMPLETION: Bio194 Safety and Ethics Research Course GRADE POINT AVERAGE: 3.5 TIME COMMITMENT PER WEEK: 12 hours per week and a minimum of 2 years NUMBER OF UNITS REQUIRED: Minimum enrollment of 3 units OTHER: On the last day of instruction of both the fall and winter quarter, students are required to turn in a 1-2 page summary of work completed. This can include background information obtained by reading the literature, details about a technique learned, and/or data generated. At the end of spring quarter, this paper will be replaced with a 15-minute scientific talk presented to the lab. All 199s are required to attend these talks. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work and data collection, proper use of lab equipment, following appropriate lab and university-mandated safety protocols, initiative and overall enthusiasm for research. LOCATION OF RESEARCH: 845 Health Science Road, 2030 Sue & Bill Gross Hall.
Brian Cummings: email@example.com, (949) 824-3254
Elysia Davis, Ph.D. Psychiatry & Human Behavior and Pediatrics
Currently recruiting students who are fluent in Spanish for WQ13. —— RESEARCH DESCRIPTION: We are evaluating the consequences of prenatal exposure to stress and stress hormones for fetal, infant and child development in several NIH funded research protocols. Students working on this project will have the opportunity assist with data collection for several fun and interesting studies of child development. Prior experience working with children is preferred, but not required. We are looking for highly motivated students with an interest in medicine, psychology, biology, or public health, who are willing to work 10-15 hours/week for a minimum of 1 year. Responsibilities will include: administering assessments of child temperament, conducting standardized interviews, evaluating biological and psychosocial indicators of maternal and child stress, and database management. Training will be provided. Students should have access to transportation to and from the Medical Center. REQUIREMENTS TO PARTICIPATE: Transportation to and from the research site, minimum one year commitment, reliable, an interest in working with young children. COURSE COMPLETION: N/A GRADE POINT AVERAGE: N/A TIME COMMITMENT PER WEEK: 10-15 hours per week NUMBER OF UNITS REQUIRED: at least 3 units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: hours completed and quality of work completed. OFFICE LOCATION: 333 City Blvd. West, Orange suite 1200
Elysia Davis: firstname.lastname@example.org, (714) 940-1898
Ralph Delfino, M.D., Ph.D. Epidemiology
RESEARCH DESCRIPTION: RESEARCH DESCRIPTION: Dr. Delfino’s research evaluates multiple clinical, biological and genetic factors in order to understand the effects of air pollutants on respiratory health, cardiovascular function, oxidative stress, and airway and systemic inflammation. This is being accomplished with cohort panel studies in human subjects involving repeated measures of exposures and outcomes to obtain precise estimates of exposure-response relationships. Each subject serves as his or her own control. The goal is to understand the chemical composition, size factions and properties of particles that lead to observed health effects, and to trace these characteristics back to their sources. This opportunity would be appropriate for students interested in biostatistical methods as they are used in medical research, clinical and medical aspects of the environmental sciences as they relate to human health and chronic diseases. REQUIREMENTS TO PARTICIPATE: The motivation and interest in medical research and the intention to pursue a post-baccalaureate degree. Upper division enrollment status with completion of inorganic chemistry, organic chemistry. Completion of calculus or statistics courses equivalent to at least MATH 2A, MATH 2B and STATS 7. Experience with SAS software is desirable, but not required. GRADE POINT AVERAGE: Minimum GPA of 3.00 TIME COMMITMENT PER WEEK: 8 to 12 hours per week with a minimum commitment of 3 consecutive academic quarters. COURSE COMPLETION: Letter grade enrollment only with grade based on student’s quality of work, attention to detail, respect for scientific data and completion of assigned work. Interested students may visit: http://www.epi.uci.edu/undergraduate_research.asp for additional information. OFFICE LOCATION: Main Campus – 224 Irvine Hall, School of Medicine. GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: 8 to 12 hours per week with a minimum commitment of 3 consecutive academic quarters. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Letter Grade. LOCATION OF RESEARCH: Irvine Hall, and Community retirement centers.
Sentelle Eubanks: Sentelle@uci.edu, (949) 824-3261
Hamid Djalilian, Otolaryngology-Head and Neck Surgery
RESEARCH DESCRIPTION: The purpose of this project is to use a novel method to stimulate the facial, hearing and balance nerves using a penetrating electrode. Restoring hearing, balance, or facial function will be attempted by stimulating the respective nerves in an animal model. REQUIREMENTS TO PARTICIPATE: Life sciences or engineering major or concentration GRADE POINT AVERAGE: 3 or higher TIME COMMITMENT PER WEEK: 8 hrs FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Completion of assigned tasks, feedback on experiments, reading. OFFICE LOCATION: UCI Medical Center Bldg 56, Suite 500
Hamid Djalilian: email@example.com, (714) 456-5853
Robert Edwards, M.D./Ph.D. Pathology
We study a mouse model of inflammatory bowel disease. The mouse is knocked out of the pertussis-toxin sensitive G-protein alpha subunits, Gia2. These animals spontaneously develop inflammation in the colon after 6 weeks of age which mimics Crohn’s disease; these mice subsequently develop colon cancer. Our work has identified a number of signaling abnormalities whose potential contribution to the development of disease is being studied. We are interested in how the lack of Gia2 affects the development of the immune system, the intestinal epithelium, and how different cell types (epithelial, stromal, and lymphoid) that lack Gia2 interact in regulating mucosal immune responses and the development of cancer in these mice. The work involves mouse husbandry, animal and tissue culture experiments, nucleic acid protein work, and an array of analyte determinations. Completed standard prerequisites for Bio 199, at least a sophomore or greater. Prefer students with expressed interest in aspirations for advanced degrees in biological sciences. GPA 3.3 or greater. Prefer at least a 2 quarter commitment. 8-10 hours/wk, 4-5 hour blocks preferred.
Robert Edwards: firstname.lastname@example.org, (949) 824-8576
Gregory, R.D. Evans, M.D., F.A.C.S. Aesthetic and Plastic Surgery Institute
RESEARCH DESCRIPTION: The focus of our lab is tissue engineering. Herein, we work in several different fields: 1. Genetically transfected human embryonic kidney stem cells to produce NGF secretion and to improve peripheral nerve regeneration; 2. Improvement of peripheral nerve regeneration by human adipose derived stem cells differentiated into neural lineage cells; 3. Direct differentiation of human adipose derived stem cells into beta-islet cells; 4. Microcirculation in free flaps, impact of tissue harvest and ischemia reperfusion injury; 5. Improvement of wound healing by enhanced cryoprecipitate; 6. Early detection of vascular thrombosis and disturbances by modulated imaging. Students who are interested will learn about basic techniques in cell cultures, molecular techniques as RT-PCR, ELISA, immunohistology, immunocytology, Western Blot, histomorphometry, and will be involved in animal models including functional evaluations of nerve injuries, etc.. REQUIREMENTS TO PARTICIPATE: 3 quarter minimum commitment, willing to work with rats, some knowledge in medical statistics, experiences in molecular techniques preferred. COURSE COMPLETION: Standard prerequisites for Bio 199 GRADE POINT AVERAGE: 3.5 or greater TIME COMMITMENT PER WEEK: At least 10 hours per week, Blocks of 2-3 hours minimum NUMBER OF UNITS REQUIRED: 3 minimum FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Attendance, quality of work, dedication, empathy. OFFICE LOCATION: 200 S. Manchester Ave., Suite 650, Orange, CA 92868
Gregory Evans: email@example.com, (714) 456-5755
Mark Fisher, M.D. Neurology and Anatomy & Neurobiology
RESEARCH DESCRIPTION: Laboratory of Stroke and Vascular Neurobiology: The laboratory focuses on fundamental mechanisms of stroke, a leading cause of death in North America. Stroke is usually caused by blood clots blocking arteries of the brain, or by excessive bleeding in the brain. The laboratory investigates how blood clot formation and bleeding are regulated by the brain, a process referred to as “brain specific hemostasis regulation”. We use cell culture models of the brain microvasculature (“blood-brain barrier”) and animal models of experimental stroke and brain hemorrhage. REQUIREMENTS TO PARTICIPATE: At least two quarter commitment COURSE COMPLETION: Basic understanding of biological sciences GRADE POINT AVERAGE: 3.0 or higher TIME COMMITMENT PER WEEK: 8 hours minimum NUMBER OF UNITS REQUIRED: 1-4 units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Oral and written presentations. OFFICE LOCATION: Shanbrom Hall, Room 121, UC Irvine Medical Center
Mark Fisher: firstname.lastname@example.org, (714) 456-6856
Lisa A. Flanagan, Pathology and Laboratory Medicine
RESEARCH DESCRIPTION: Neural stem cells hold great promise as potential therapuetic agents for a variety of central nervous system diseases and injuries. Our lab is interested in intrinsic and extrinsic regulators of cortical neural stem cell proliferation, neurogenesis, and neurite outgrowth/regeneration. Projects will utilize cell culture, immunocytochemistry, microscopy, collaborations with colleagues in biomedical engineering, and data analysis. Resumes with a completed course list can be sent by email (email@example.com). REQUIREMENTS TO PARTICIPATE: interest in cell biology and neuroscience, highly motivated, good organizational skills COURSE COMPLETION: Bio 194S, preferred completion of laboratory coursework GRADE POINT AVERAGE: 3.0 minimum TIME COMMITMENT PER WEEK: 10+ hours/week, 1 year comittment NUMBER OF UNITS REQUIRED: 3 units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: completion of assigned tasks, understanding of biology, communication skills. OFFICE LOCATION: D433 Medical Sciences D
Lisa Flanagan: LFLANAGA@UCI.EDU, (949) 824-5786
Kirsten Fleming, Ph.D. Psychiatry
Topic: emotion and mental illness. Study of people’s reactions to emotional material through subjective ratings, psychophysiological responses and brain imaging. Experience with these patient groups: depression, schizophrenia, Alzheimer’s, etc. Some work done at the UCI Brain scanning. Prefers commitment of two years and students interested in neuroscience, mental illness, and brain imaging.
Kirsten Fleming: firstname.lastname@example.org, (714) 456-5936
Donald Forthal, M.D. Medicine
Requirements: GPA 3.5 or better; must be willing to commit at least 15 hours/week and a minimum of 1 year. Description: The laboratory focuses on immune responses to viruses, particularly HIV. We study how antibodies interact with receptors on natural killer cells and macrophages and thereby inhibit viral replication. Students perform a number of techniques including PCR, cell-surface staining, cell culture, and ELISA. Students do not deal directly with HIV. It is hoped that student’s can develop their own projects.
Donald Forthal: email@example.com, (949) 824-3365
Michelle Fortier, Ph.D. Anesthesiology and Perioperative Care
Dr. Fortier is Assistant Professor in the Department of Anesthesiology and Perioperative Care and co-director of the UCI Center on Stress and Health (CSH) which is located at 505 S. Main St, Suite 940, Orange, CA 92868. The UCI Center on Stress & Health (CSH) is a research center comprised of multi-disciplinary collaboration between anesthesiologists, psychologists, surgeons, pediatricians, nurses, child life specialists, biomedical engineers, and computer scientists for the primary objective of assisting children and families manage pain, anxiety and stress surrounding the medical environment and disease burden. Dr. Zeev Kain, Professor and Chair of Anesthesiology and Associate Dean for Clinical Research at UCI, is director of CSH. Current research projects include: examining pain in pediatric oncology patients, behavioral interventions to reduce children’s perioperative pain and distress, examining factors that predict preoperative anxiety in children, and understanding potential ethnic and cultural differences in pediatric and adult pain. Because of the large population of Spanish speaking families at CHOC, we are especially interested in bilingual students who may assist with the recruitment of these families to our research studies. REQUIREMENTS TO PARTICIPATE: Students should be prepared to develop independent projects and a one year commitment is required. Reliability and professionalism are very important. COURSE COMPLETION: n/a GRADE POINT AVERAGE: 3.0 or higher TIME COMMITMENT PER WEEK: 10 hours per week NUMBER OF UNITS REQUIRED: 3 units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Time committed to research and quality of work completed. LOCATION OF RESEARCH: Children’s Hospital of Orange County
Ariana Martinez: firstname.lastname@example.org, (714) 480-0039
John Christian Fox, M.D. Emergency Medicine
Requirements: 3.5 overall GPA, Tuesday/Thursday availability, and two year commitment. Four hours/unit/wk. Minimum of 3 units. Ability to work independently as well as in a group setting. Description: Emergency Ultrasound involves the use of portable ultrasound machines at the bedside of patients in the emergency department. The new field requires clinical research that supports its implementation by proving its safety and efficacy in a wide variety of applications. Currently we have over 20 protocols ranging from first trimester complications of pregnancy to medical student ultrasound. 199 students are expected to attend the weekly research meetings held in Dr. Fox’s office in the Medical Education building at the main campus. Also, accuracy of data entry/analysis with an emphasis on clinical application will be addressed. Opportunities for publication are available.
John Christian Fox: email@example.com
Kathryn Steinhaus French, Pediatrics/Genetics
RESEARCH DESCRIPTION: This project involves obtaining pregnancy outcome information from patients undergoing amniocentesis or CVS procedures at UCI Medical Center. The outcome information is gathered on each perinatologist to determine if patients undergoing these invasive tests have a higher than acceptable risk of pregnancy complications. Students also assist in data entry and are given the opportunity to participate in patient conferences as well as observe genetic counseling and prenatal testing procedures such as ultrasound, amniocentesis and CVS at UCI Medical Center REQUIREMENTS TO PARTICIPATE: 3 quarter minimum commitment COURSE COMPLETION: Open GRADE POINT AVERAGE: Open TIME COMMITMENT PER WEEK: 4-8 hours per week NUMBER OF UNITS REQUIRED: 2 or 4 OTHER: Students interested in Genetic Counseling, obstetrics, genetics and/or obstetrics are encouraged to participate FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Students are graded based on accurate and timely completion of duties performed in a professional manner. OFFICE LOCATION: City Tower, UCI Medical Center, Orange. ACCEPTING BIO. 199 STUDENTS FOR: Summer 2011 & Fall Quarter 2011.
Kathryn Steinhaus French: firstname.lastname@example.org, (714) 456-6883
Ron Frostig, Ph.D. Neurobiology and Behavior
RESEARCH DESCRIPTION: Our main research interests include basic and preclinical research of the structure, function and plasticity of the cerebral cortex – the most sophisticated part of the brain believed to support higher brain functions like perception and learning and memory. Plasticity refers to the unique ability of the cortex to modify its structure and function depending on factors such as changes in the animal’s environment, injury, and learning and memory. Most of our research focuses on the sensory subregions of the cortex (somatosensory, auditory and visual) in adult rodents (rats and mice). We apply many techniques to investigate the cortex such as functional imaging, neuronal recordings, histology, pharmacology, gene manipulations, and behavior. Examples of some recent research projects include: identifying a new type of plasticity where mild sensory stimulation (tactile or auditory) can completely protect the cortex from stroke; demonstrating massive cortical plasticity (structure and function) following the transfer of rodents from their single, small cages to a large specialized environment (‘naturalistic habitat’) that encourages rodents to interact, play, dig tunnels, and forage; and elucidating fundamental principles of how structure and function of sensory cortex interact to support perception. For more details see our website at: http://frostiglab.bio.uci.edu/ REQUIREMENTS TO PARTICIPATE: We are looking for students with strong curiosity and high level of self-motivation. COURSE COMPLETION: Bio 110 recommended but not essential. GRADE POINT AVERAGE: Minimum of 3.3. OTHER: We are looking for at least 1 year commitment FACULTY MEANS OF EVALUATION FOR COURSE GRADE: dependability, level of understanding and performance, and overall participation. LOCATION OF RESEARCH: McGaugh Hall.
Ron Frostig: email@example.com, (949) 824-2883
John Fruehauf, M.D./Ph.D. Oncology
Description: Students will carry out in vitro cell line work to determine the effects of anticancer agents on tumor cell and tumor vascular cell growth. Antiangiogenesis models will be emphasized. Cancer pharmacology will be reviewed. For some studies, biomarker correlates with drug response will be determined using immunohistochemistry, image analysis, flow cytometry, gene expression arrays and proteomics techniques. Students will be expected to define a hypothesis driven project, present a15 minute lecture summarizing their objectives, prepare a mid term oral and written report, and present a final oral and written report. When data are of adequate quality, the student will be encouraged to submit a manuscript for publication and to present their work at the UCI science fair. Prerequisites: Introductory Biology and Chemistry; Bio 194S; Cum GPA>3.0. Organic Chemistry and Biochemistry preferred.
John Fruehauf: firstname.lastname@example.org, (714) 456-5153
David Fruman, Mol Biol Biochem
RESEARCH DESCRIPTION: Phosphoinositide 3-kinases (PI3Ks) are a group of signaling enzymes that regulate most aspects of immune cell development and function. Increased PI3K signaling is associated with autoimmunity and cancer. Dr. Fruman’s laboratory uses genetic and pharmacological approaches to define the unique and shared functions of PI3K isoforms in different lymphocyte subsets. The laboratory is also interested in the kinase mTOR, that is activated downstream of PI3K and other signals. Dr. Fruman’s research group is testing novel inhibitors of PI3K and mTOR for potential therapeutic value in autoimmune diseases and leukemia. REQUIREMENTS TO PARTICIPATE: Attendance at lab meeting weekly, with an oral presentation once per quarter starting in the second quarter of enrollment. Submission of written summary of research progress at the end of each quarter. COURSE COMPLETION: Bio 97, 98 GRADE POINT AVERAGE: Minimum 3.0 in Biological Sciences and Physical Sciences courses TIME COMMITMENT PER WEEK: 3-4 hours per unit. NUMBER OF UNITS REQUIRED: Flexible. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Effort, attendance and progress in research skills. LOCATION OF RESEARCH: 3407 McGaugh Hall.
David Fruman: email@example.com, (949) 824-1947
Pietro Galassetti, M.D., Ph.D. Pediatrics, General Clinical Research Center
RESEARCH DESCRIPTION: Our lab currently has 4 human research protocols funded by the NIH and/or JDRF. 1) We are researching the adaptive responses to exercise in Type 1 Diabetic children/adolescents with hypoglycemia and/or hyperglycemia. Cytokines such as (IL-4, IL-6, IL-1α, IL-1β, TNF-α, ), growth factors (IGF-I, IGF BP-1), and neuroendocrine components (Glucagon, Cortisol, GH, Epi, Nor-Epi) are measured via ELISA and LUMINEX assay techniques. 2) The second protocol is aimed at defining the inflammatory and oxidative stress responses during exercise in children with obesity/metabolic syndrome, and in healthy controls, in fasting conditions and after ingestion of a high-fat meal. Data will be analyzed attempting to ascertain the effects of maturational status, gender, and physical fitness. In addition to the assays listed above, a broader panel of oxidative markers will be used, including measurement of leukocyte gene expression. Assessment of total and regional body composition by DEXA, and assessment of the cardio-respiratory responses to exercise will also be performed. 3) The third protocol is a joint effort with the Blake/Rowland lab in the Department of Chemistry to define and identify correlations between exhaled breath gas profiles, plasma glucose, insulin, FFAs, ketones and oxidative stress markers in healthy and Type 1 Diabetic adults, in an effort that may lead to the creation of new techniques allowing the accurate, non-invasive measurements of these variables. In addition to the assays listed above, a sophisticated gas chromatography/mass spectrometry analysis of expired gases is performed. 4) The fourth protocol researches the effects of exercise on the immune system’s responses in adult males. Strenuous exercise is used to stimulate cellular and humoral changes through recruitment and activation of blood leukocyte subpopulations. For key immuno-modulatory mediators, in addition to systemic circulating concentrations, also levels of gene expression and intracellular concentrations in leukocyte subpopulations will be studied. REQUIREMENTS TO PARTICIPATE: Students interested in clinical research. Enthusiastic, responsible individual who demonstrates a willingness to learn. Requires working an occasional weekend day (approximately 1-2 days per month). Good organizational and time management skills are crucial. Students should have access to transportation to and from the Medical Center. A commitment of at least two consecutive quarters is necessary. COURSE COMPLETION: Completion of standard prerequisites for 199. GRADE POINT AVERAGE: Minimum 2.5 GPA TIME COMMITMENT PER WEEK: 8-12 hours/week NUMBER OF UNITS REQUIRED: 2-3 OTHER: Students will have the opportunity to learn about working with human subjects in clinical research environment. Review of ongoing research projects (grants) and UCI regulatory documents (IRB, GCRC). Under supervision, the student will assist with (including but not limited to) plasma analysis on Beckman Glucose Analyzer, recording and entering of data in existing databases relating to research studies, and review of pertinent literature. Structure and organize data into presentation formats for national and local meetings, journal club meetings and scientific manuscript submissions. Will meet weekly with PI, staff, and participate in department and laboratory meetings. Training will be provided. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Attendance, quality of work and performance of assigned tasks, participation in laboratory meetings, and acquired knowledge of research field. OFFICE LOCATION: 1111 Hewitt Hall. If interested, please contact Rebecca Flores (firstname.lastname@example.org, 949-824-4433) and cc Dr. Galassetti (email@example.com) on your correspondence.”
Rebecca Flores: firstname.lastname@example.org, (949) 824-4433
Anand Ganesan, MD.,Ph.D. Dermatology and Biological Chemistry
RESEARCH DESCRIPTION: Our laboratory is interested in understanding the molecular mechanisms that regulate the production of melanin pigment in the melanocyte and the molecular mechanisms that control melanoma chemoresistance against multiple agents. Our work utilizes tissue culture models, mouse models, and also includes translational studies with human tissues. REQUIREMENTS TO PARTICIPATE: Junior or Senior COURSE COMPLETION: completed introductory biology course and preferably a biochemistry or molecular biology laboratory course GRADE POINT AVERAGE: 3.5 TIME COMMITMENT PER WEEK: 20-30 hours NUMBER OF UNITS REQUIRED: 3-4 OTHER: The undergraduate will need to be committed to research work and need to be able to work independently. Undergraduates with interest in pursuing a PhD or MD/PhD degree are preferred over those that are interested in entering medical school. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: The student will be evaluated based on their presentations in group meeting and their interactions with graduate students and postdoctoral fellows in the lab. LOCATION OF RESEARCH: Sprague Hall.
Anand Ganesan: email@example.com, (949) 824-0547
David Gardiner, Dev & Cell Biology
Role of signaling pathways in the induction of scar-free wound healing and limb regeneration. Successful completion of first year courses – strong interest in regeneration. GPA 3.0. Minimum of 10 hours/wk. Typically 4 units. *Note: Enroll in course code under Dr. Susan Bryant.
David Gardiner: firstname.lastname@example.org, (949) 824-2792
Brandon Gaut, Ph.D. Ecology & Evo
Brandon Gaut: email@example.com, (949) 824-2564
Jean Gehricke, Ph.D. Pediatrics, Child Development Center
TITLE: Research on smoking and ADHD. RESEARCH DESCRIPTION: Dr. Gehricke’s research focuses on why individuals with ADHD have higher smoking rates and lower cessation rates compared to the general population. Learn about the effects of nicotine and cigarette smoke on human behavior and brain circuitry as well as the genetic and environmental risk factors that lead to smoking initiation and nicotine addiction. Students will be trained in implementing study protocols, data collection techniques, data entry, and analysis. Good opportunity for students interested in careers in medicine, clinical psychology, and drug abuse treatment and prevention. REQUIREMENTS TO PARTICIPATE: Minimum commitment of one year. TIME COMMITMENT PER WEEK: 8-10 hours/ week. NUMBER OF UNITS REQUIRED: 3-4. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Reliability and consistency in attendance. Completion of assignments and required hours. Discussions of research papers. Brief paper in one area of drug abuse research. OFFICE LOCATION: 19722 MacArthur Blvd., Irvine.
Jean Gehricke: firstname.lastname@example.org, (949) 824-1834
Donovan P. German, Ph.D. Ecology and Evolutionary Biology
RESEARCH DESCRIPTION: Spanning from the molecular to the whole-organism level, research in my laboratory is focused on the energy acquisition strategies of organisms. In short, I am interested in understanding how organisms make a living and the consequences of different energy acquisition strategies for ecosystem fluxes. Hence, this truly is ecological physiology. Current projects include work with marine and freshwater fishes, as well as microbes from terrestrial and aquatic systems. Student projects may focus on field work, laboratory studies, and/or computer work with bioinformatics. REQUIREMENTS TO PARTICIPATE: Students should have a strong interest in ecological physiology and be prepared to develop independent projects. I expect a commitment of 10 hours per week on research. A multi-quarter commitment is strongly preferred, and students will be expected to participate in lab activities and weekly lab meetings. To apply for a position, please visit http://german.bio.uci.edu , download the Bio 199 Research Application form, and send the form back to email@example.com. COURSE COMPLETION: Bio 194. Students should at least be in second year of instruction, although exceptional first year students will be considered. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: grades will be based on time committed to the project and the quality of research. LOCATION OF RESEARCH: 5309 McGaugh Hall.
Donovan German: firstname.lastname@example.org, (949) 824-2772
Paul Gershon, Ph.D. Molecular Biology & Biochemistry
I am active in four areas: (1) We operate a protein (roteomics? mass spectrometry facility containing two powerful, state-of-the-art tandem mass spectrometers along with nanoflow/nanocapillary two-dimensional peptide fractionation HPLC with robotics. Last year, several 199s deftly learned to operate these instruments and used them to, among other things, identify all the proteins in some of the world largest viruses. We will now be identifying and quantitating the proteins characteristic of diseased/tumorigenic cells and developmental abnormalities. (2) My lab is currently funded to investigate the structure and molecular dynamics of the enzyme poly(A) polymerase (PAP), using the vaccinia virus enzyme as a model. The vaccinia PAP was the first PAP for which a gene was identified (by the P.I.), and we recently learned its three-dimensional structure. Vaccinia PAP is the only known polymerase that can translocate independently on single-stranded nucleic acid. How does it do this on a non-rigid polymer? Come to my lab and solve the mystery. (3) A collaboration between my lab and that of Dr. Alex McPherson (MB&B) has led to the clearest images obtained thus far of vaccinia virus particles and subviral assemblies, providing a unique opportunity to identify viral proteins and functions present in various subviral assemblies. This dovetails well with protein mass spectrometry (above). (4) I am also funded to investigate the catalytic mechanism of RNA O-methylation. Vaccinia virus protein VP39 provided the first three-dimensional structure for any poxvirus protein and any RNA methyltransferase. The structure was then solved again, with bound RNA substrate and cofactor. Using various chemical, biochemical and NMR techniques, we are elucidating aspects of its catalytic mechanism from hypotheses arising from the three-dimensional structure. Overall, prior undergraduate interns in my lab have been included as authors on manuscripts submitted for publication, and some current ones will be.
Paul Gershon: email@example.com, (949) 824-9606, 7954
Charles Glabe, Ph.D. Molecular Biology and Biochemistry
RESEARCH DESCRIPTION: We work primarily on Alzheimer’s disease, but we also work on other amyloid-related degenerative diseases, like Parkinson’s disease, Huntington’s disease and type II diabetes. We are focused on amyloid aggregation and self assembly and the structure of amyloid aggregates. We are especially interested in the mechanisms of amyloid in disease pathogenesis and the development of immunological approaches to therapeutic development. REQUIREMENTS TO PARTICIPATE: You need to be a student. You also need to convince me of your commitment to research and your intellectual ability to conduct research. The earlier you start, the better. We are looking for a mutually beneficial experience for the student and your direct laboratory supervisor. This is not like a job in the sense that we have positions open that we are looking to fill. You need to convince me to make space for you in a laboratory that is already crowded. COURSE COMPLETION: Yes GRADE POINT AVERAGE: Typically an A. If you are not doing A quality work, it is not beneficial for either of us and you will need to consider doing something else. TIME COMMITMENT PER WEEK: 9 hours per week NUMBER OF UNITS REQUIRED: 3 units OTHER: Participating in lab meetings when possible. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Showing up on time, putting in the required hours and making progress on your project. Your daily lab supervisor will be a graduate student or postdoctoral fellow who will also help evaluate your participation and progress. LOCATION OF RESEARCH: 3438 McGaugh Hall.
Charles Glabe: firstname.lastname@example.org, (949) 824-6081
Laura Glynn, Ph.D. Psychiatry
Students will work on research studies involving the role of biological and psychological processes in pregnancy and on prenatal factors influencing later psychiatric health. The research protocols are varied and students will participate in EEG, archival chart review and data analysis. Students who are willing to make a three quarter commitment are preferred. Training will be provided.
Laura Glynn: email@example.com, (714) 940-1925
Alan L. Goldin, Microbiology & Molecular Genetics
RESEARCH DESCRIPTION: Our lab investigates the role of voltage-gated sodium channels in normal and abnormal physiology of the CNS, with two goals. The first is to determine how sodium channel mutations cause CNS disease. Specifically, we are studying the effects of epilepsy causing mutations in genes encoding human CNS sodium channels by using mouse models. The primary model is Generalized Epilepsy with Febrile Seizures Plus, which is caused by mutations in sodium channel subunits. We and our collaborators have constructed a number of mouse models expressing the sodium channel mutations that cause this disease. We are now using a variety of electrophysiological approaches to understand how the mutations alter excitability of individual neurons and the overall network. The second goal is to determine how different sodium channels localize in different regions of CNS neurons. There are multiple sodium channel isoforms, including four that are highly expressed in the CNS. These subtypes are present in different intracellular locations, and we are expressing tagged channels in neurons to identify the portions of the molecule that are important for the localization differences. In addition, we are examining the localization properties of the mutant channels that cause epilepsy to determine if those alterations affect trafficking. REQUIREMENTS TO PARTICIPATE: Minimum 1 year commitment COURSE COMPLETION: Biochemistry/Chemistry and Neuroscience GRADE POINT AVERAGE: 3.2 TIME COMMITMENT PER WEEK: Minimum 6 hours NUMBER OF UNITS REQUIRED: Minimum 2 units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Effort, Attendance, Quality of Work. LOCATION OF RESEARCH: 266 Medical Sciences C .
Alan Goldin: firstname.lastname@example.org, (949) 824-5334
Sastry Gollapudi, Ph.D. School of Medicine
RESEARCH DESCRIPTION: Our research focuses on the role of Toll Like receptors (TLRs) in Breast cancer cell survival. These receptors are pattern recognition receptors. Pattern recognition receptors are expressed on a wide variety of cells and they promote phagocytosis. TLRs signal via conserved pathways to induce  secretion of a number of proinflammatory cytokines,  apoptosis, and  potentiate apoptosis induced by anti-cancer agents. The expression of TLRs in breast cancer cells is suggested by the capacity of breast cancer cells to phagocytose yeast (which is recognized by TLR 2 and dectin, a PRR that detects beta glucan of yeast cell wall) and induction of apoptosis in breast cancer cells by yeast cell wall components. Students will gain experience in a range of research techniques including cancer cell biology , molecular biology and Biochemistry REQUIREMENTS TO PARTICIPATE: Students beginning in summer and continuing through the year will be given preference COURSE COMPLETION: Basic course work in Biology and Biochemistry GRADE POINT AVERAGE:3.0 and above TIME COMMITMENT PER WEEK: 16-24 hours /week NUMBER OF UNITS REQUIRED: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: The quality of laboratory work and presentation of their research findings, both written and oral, in the lab meetings will figure eqully in the grade evaluation. OFFICE LOCATION: Room C348, MedSCi Bld 1
Sastry Gollapudi: email@example.com, (949) 559-5820
Celia Goulding, Ph.D. Molecular Biology& Biochemistry
My research is based on structure-function determination of Mycobacterium tuberculosis proteins in the hope of finding novel anti-TB drug targets. The techniques that we utilize include X-ray crystallography, biochemical characterization and mass spectrometry. My main focus is on a mycobacterial iron up-take system that scavenges iron from humans in the form of heme, and then uptakes this heme to be broken down for iron usage either within the bacterial membrane or cytosol The student research projects may include cloning, protein expression and purification and crystallization trials initially. There will also be some protein-protein interaction experiments to carry out. Completion of Bio 194S (biosafety and ethics) is required and a basic course in biochemistry/chemistry would be preferable. Must be highly motivated and be prepared to work12 hours/wk. 3 units. GPA 3.2 or better.
Celia Goulding: firstname.lastname@example.org, (949) 824-0337
Kim Green, Neurobiology and Behavior
RESEARCH DESCRIPTION: Research into the understanding and treatment of Alzheimer’s disease and other neurodegenerative disorders, using a variety of tissue cultures and mouse models of the disease. In particular, 199 students will assist with analyzing tissue from cells and mice that have been treated with blockers of calcium channels, or with modulators of the inflammatory system. REQUIREMENTS TO PARTICIPATE: Bio Major COURSE COMPLETION: Junior or above GRADE POINT AVERAGE: 3.3 TIME COMMITMENT PER WEEK: 10+ hours NUMBER OF UNITS REQUIRED: 2. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Attendance and competence. LOCATION OF RESEARCH: 3400 Biological Sciences 3.
Kim Green: email@example.com, (949) 824-3859
Sudhir Gupta, M.B./B.S./Ph.D. Medicine
Two positions available. One would work on molecular biology technology involved in dissecting some novel gene from two infants with unique congenital immunodeficiency and other for molecular mechanisms of cell death. Should have minimum GPA of 3.8 who are majoring in Biology.
Sudhir Gupta: firstname.lastname@example.org, (949) 824-5818
Brad Hawkins, Ph.D. Ecology
Project involves a study of the global pattern of species diversity for birds. Students must be willing to work at least 6 hours per week (3 hours per unit). Students who work on project a second year are expected to conduct a small independent study related to the major project.
Brad Hawkins: email@example.com, (949) 824-5384
Klemens Hertel, Microbiology and Molecular Genetics (MMG)
RESEARCH DESCRIPTION: With the completion of the human genome project, it has become clear that the sheer number of genes cannot account for the complexity of the human proteome. Among several proposed mechanisms, alternative pre-mRNA splicing is considered to be one of the most efficient and widespread avenues to generate multiple protein isoforms from individual genes. Research in the Hertel laboratory focuses on understanding the mechanisms that allow for the generation of alternative splicing patterns. Specifically, we are interested in gaining insights into the most critical step of generating mRNA diversity; the processes of splice-site selection and pairing. REQUIREMENTS TO PARTICIPATE: Knowledge of Molecular Biology TIME COMMITMENT PER WEEK: 15-20hrs/week NUMBER OF UNITS REQUIRED: tba FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Performance in laboratory, dedication to research, quarterly presentation on research progress. LOCATION OF RESEARCH: Med Sci I, Rm C290.
Klemens Hertel: firstname.lastname@example.org, (949) 737-2074
Bang H. Hoang, M.D. Orthopaedic Surgery
RESEARCH DESCRIPTION: Orthopaedic Oncology Lab focusing in molecular biology and genetics of bone and soft tissue tumors. Techniques include DNA and protein gel electrophoresis, tissue culture, gene transfection, microscopy, biological assays, immunohistochemistry. REQUIREMENTS TO PARTICIPATE: complete Clinical package to work at UCIMC laboratory. COURSE COMPLETION: Bio. 194 Safety & Ethics GRADE POINT AVERAGE: 3.3 or above TIME COMMITMENT PER WEEK: 3-4 hours per week for each credit NUMBER OF UNITS REQUIRED: 1-5 credits FACULTY MEANS OF EVALUATION FOR COURSE GRADE: completion of research proposal, attendance, presentation at lab meeting, attending monthly lab meetings, reading journal articles. OFFICE LOCATION: UCIMC, Pavillion 3, second floor.
Bang Hoang: email@example.com, (714) 456-7752
Franz Hoffmann, Ph.D. Development & Cell Bio
Franz Hoffmann: firstname.lastname@example.org, (949) 824-4346
Todd Holmes, Ph.D. Physiology and Biophysics
RESEARCH DESCRIPTION: Circadian Rhythms REQUIREMENTS TO PARTICIPATE: Student interview COURSE COMPLETION: BIO 194 GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: 10 hour minimum NUMBER OF UNITS REQUIRED: 3 – 4 (3 minimum) FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Student presentation and Lab meeting attendance. OFFICE LOCATION: D340 Medical Science I, Irvine, CA 92697-4560
Todd Holmes: email@example.com, (949) 824-0006
Naoto Hoshi, MD., Ph.D. Pharmacology
RESEARCH DESCRIPTION: We study how protein complexes regulate ion channels. Students will have opportunity to participate in experiments covering various aspects of pharmacological research: molecular (cloning) and cellular (cell culture) biology (western blot) and electrophysiology (if desire). REQUIREMENTS TO PARTICIPATE: students interested in pharmacological/pharmaceutical research; Preference to those with experience in biological and/or chemical techniques. COURSE COMPLETION: Course requirements vary by project. GRADE POINT AVERAGE: 3.3 TIME COMMITMENT PER WEEK: > 8 hrs/week NUMBER OF UNITS REQUIRED: >2 OTHER: 360 C Med Surge II FACULTY MEANS OF EVALUATION FOR COURSE GRADE: participation, willingness to learn, responsibility. LOCATION OF RESEARCH: 309 Med Surge II
Naoto Hoshi: firstname.lastname@example.org, (949) 824-0970
Lan Huang, Ph.D. Physiology, Biophysics
Our research focuses on developing and employing mass spectrometry-based proteomic approaches to answer a series of biological questions related to cancer diagnostics and treatment. Current projects include characterization of proteasome complex composition, their post-translational modifications and mapping protein interacting network in normal and cancer cells; investigation of protein ubiquitination and ubiquitin-like protein modifications to understand their functions in turmorigenesis. Requirements: completion of organic chemistry, cell biology, biochemistry. GPA 3.0 or higher, one year commitment.
Lan Huang: email@example.com, (949) 824-8548
Bradley Hughes, Ecology and Evolutionary Biology
Interdisciplinary Media Development in Science Education RESEARCH DESCRIPTION: This project will conduct two types of research: A) scientific video-based media development, which will generate an experimental interdisciplinary curriculum designed to help English language learners and other students better understand scientific concepts; B) evaluation of the effectiveness of this curriculum through teacher focus groups, surveys, and pre-post tests administered to treatment and control groups. Student researchers will develop a broad knowledge of over a dozen media technology production tools and gain a functional working knowledge of video editing using Final Cut Pro X. This project is a partnership between the San Diego Unified School District and the UCI Center for Arts, Sciences, and Sustainability. REQUIREMENTS TO PARTICIPATE: Requisite skills include familiarity with computer and media development applications, along with basic research and analysis skills. Preference will be given to students who can travel to San Diego on some Fridays during fall term. TIME COMMITMENT PER WEEK: 8-12 hours. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work, proper use of equipment, following appropriate procedures, and initiative and overall enthusiasm for video-based media development. LOCATION OF RESEARCH: 341 Steinhaus Hall.
Bradley Hughes: firstname.lastname@example.org, (949) 824-2359
Travis E. Huxman, Ecology and Evolutionary Biology
RESEARCH DESCRIPTION: The Huxman laboratory focuses on understanding the evolution of functional traits in plants and how plants influence ecosystem processes. A primary focus are questions that relate to understanding stress tolerance and growth potential in native plants, how environmental factors affect primary production, how plants influence the water cycle and affect the physical environment, and how either disturbance, human influence or global change may affect these processes. Student projects may focus on laboratory, growth chamber, or greenhouse studies, field and common garden experiments, and/or data synthesis, analysis or model assimilation. Field work may include projects associated with the Center for Environmental Biology on local UC Reserve lands, Orange County Open Space, State Parks or in the National Forest. Summer and academic year positions are available. REQUIREMENTS TO PARTICIPATE: Students will develop independent projects and spend at minimum 10 hours per week on research. Participation over multiple quarters is strongly preferred and students will also be expected to participate in laboratory / Center meetings and activities. GRADE POINT AVERAGE: 3.0 min GPA NUMBER OF UNITS REQUIRED: 2-4 units required FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Students are evaluated on quality of work, initiative, and the development of research activities through the experience. LOCATION OF RESEARCH: Steinhaus Hall 429.
Travis E. Huxman: email@example.com, (949) 824-2594
David Imagawa, M.D., Ph.D., FACS Hepatobiliary and Pancreas Surgery
RESEARCH DESCRIPTION: The Division of Hepatobiliary and Pancreas Surgery involves examination of various conditions and treatments affecting diseases of the liver, pancreas, and biliary tree. Students will be expected to attend weekly clinics on Monday mornings and Thursday afternoons, as well as work independently in the office. Student tasks will include maintaining the research database, statistical analysis, and other research duties as necessary. Ability to learn new applications. Experience with Excel, Access, SPSS, Adobe Premiere, Adobe Photoshop, Adobe Illustrator preferred. Must be willing to travel to medical center. Student will be supervised by the PI and the surgical research resident. REQUIREMENTS TO PARTICIPATE: 3.0 overall GPA and sophomore standing COURSE COMPLETION: Bio 194S. Statistics and physiology recommended but not required GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: Approximately 12 hours/week NUMBER OF UNITS REQUIRED: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work, fulfillment of time commitment OFFICE LOCATION: 101 The City Drive South Bldg 56 Room 202 Orange, CA 92868
Maki Yamamoto: firstname.lastname@example.org, (714) 456-3885
Mahtab Jafari, Pharm.D. Pharmaceutical Sciences
The use of animal models for screening and evaluating anti-aging pharmaceutical and botanical compounds is a promising approach for drug discovery. While testing anti-aging compounds using the premier animal genetic systems, Drosophila melanogaster and Caenorhabditis elegans, has already started, the fundamental biological issues involved in such screening have not been systematically formulated. As a result, after selecting potential anti-aging compounds to be tested, we need appropriate methodologies to study the pharmacology of aging in model species. Once these methodologies or rules of investigation are developed, we may consider extrapolating these experimental findings with such systems to the treatment of human aging. However, there are a number of potential artifacts, confounds, and errors that can arise in such research programs. In order to minimize these problems, I developed the following assays as the rules of investigation in anti-aging pharmacology and am in the process of applying them to a number of potential anti-aging compounds. These are the rules of investigation that I propose: Since human adulthood is almost exclusively a period of aging, data that conflate aging and late life should not be extrapolated to human aging. 2) The response to candidate medications should show a normal drug-dose response pattern, although not necessarily a linear response. 3) Medicated animal models should not be hypometabolic. 4) Medicated animal models should not show pronounced reductions in fertility. 5) Medicated animal models should not exhibit general nervous system depression. 6) The effect of the medication should not be highly sensitive to the culture environment. 7) The effect of the medication should not be highly dependent on the genetic ancestry of the stock employed, leaving aside inbreeding, which should be avoided because humans are not generally inbred. While these rules do not guarantee successful extrapolation of successful drug results from the animal model to humans in a clinical setting, the failure to adhere to these rules should raise doubts about such extrapolation. In my research, I attempt to address this task. Interest in a career in biomedical research is required. All students start as Bio. 198, group research students. Progress to Bio. 199 status depends on the student’s ability to work independently. NO student begins in the Bio. 199 course. 3-4 units required involving 10-12 hours/week. A 2-year commitment and a desire to apply for a UROP grant, SURP fellowship, and Excellence in Research is recommended. Must be highly motivated to complete an independent project while working closely with the research staff and PI. Biology and Chemistry Majors preferred with a minimum 3.3 GPA.
Mahtab Jafari: email@example.com, (949) 824-0145
James Jakowatz, M.D. Surgery
RESEARCH DESCRIPTION: Examination of, and maintenance of, melanoma center patient data base; outcome of research: accuracy, failure, recurrence, survival and complications in sentinel lymph node mapping. REQUIREMENTS TO PARTICIPATE: only BID 194 COURSE COMPLETION: per semester / 3-5 page paper GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: 3–4 hours/week NUMBER OF UNITS REQUIRED: 3–4 OTHER: N/A FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Accuracy of data entry / chart review success in focus on a specific clinical outcome. Example: # of patients with lymphocele or lymphodema; or, false negative lymph node basin rate / recurrence in a node basin originally staged clear. OFFICE LOCATION: UCIMC Bldg 56
James Jakowatz: firstname.lastname@example.org, (714) 456-8171
James V. Jester, Ph.D. Ophthalmology and Biomedical Engineering
RESEARCH DESCRIPTION: Research focuses on the cell and molecular biology of ocular surface and corneal disease of the eye with an interest in corneal biomechanics and ocular imaging using non-linear optical microscopy. Studies range from cell culture to animal experimentation and ex vivo examination of the eye. REQUIREMENTS TO PARTICIPATE: An interest in cell and molecular biology or bioengineering. COURSE COMPLETION: GRADE POINT AVERAGE: 3.0 and above. TIME COMMITMENT PER WEEK: 8 hours a week. NUMBER OF UNITS REQUIRED: 2 or more. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Students will be graded on laboratory attendance, quality of research data and analysis generated and the ability to present work at laboratory meetings. LOCATION OF RESEARCH: Hewitt Hall, Building 843, 2nd Floor.
James Jester: email@example.com, (949) 824-8047
Sunny Jiang, Ecology and Revolutionary Biology, Civil and Environmental Engineering
Research in Dr. Jiang’s lab focuses on the following three areas: 1) aquatic/marine microbial ecology, 2) water quality microbiology, 3) epidemiology of exposure to recreational waters. Her group uses molecular method to uncover the genomes and interaction of organisms in the environment. Over the past decade, her team has developed rapid and sensitive methods for detection and quantification of human virus contamination in aquatic samples. Their results have suggested that current coastal water standards do not adequately reflect the viral quality of recreational waters. Working together with environmental engineers, coastal physical oceanographers and remote sensing scientists, they have recently discovered that surf zone water quality is impacted by multiple factors including global climate changes, land use patterns and human activities. Working directly with the City of Newport Beach and Regional Water Quality Control Board, they have investigated the relationship between fecal indicator bacteria and human viruses in Newport Bay. The results showed that the occurrence of these two types of organisms is uncoupled largely due to the differences in the source and survival of each type. Another area of her research addresses human health risk from exposure to coastal waters. Her research group is currently developing web-based survey tools to understand the relationship between human health risk and coastal water quality. Sample projects in her lab include investigation the causes and decline of harmful algal blooms (red tides), detection of pathogens in water, epidemiological surveillance of recreational illnesses. REQUIREMENTS: Students should be prepared to develop independent projects and spend at least 10 hours per week on research. A multi-quarter commitment is strongly preferred, and students will be expected to participate in lab activities and meetings. MEANS OF EVALUATION: grades will be based on time committed to the project and the quality of research.
Sunny Jiang: firstname.lastname@example.org, (949) 824-5527
Peter Kaiser, Biological Chemistry
RESEARCH DESCRIPTION: Research in the Kaiser laboratory aims to (i) investigate fundamental mechanistic questions about cell cycle control and the ubiquitin-proteasome pathway, (ii) discover molecularpathways suitable for the development of novel strategies in cancer therapy, and (iii) develop novel approaches to directed drug design, which we apply to develop small molecules to reactivate mutant p53 in human cancer. TIME COMMITMENT PER WEEK: 8 hours/week minimum LOCATION OF RESEARCH: Hitachi (Plumwood) Building room 136
Peter Kaiser: email@example.com, (949) 824-9442
Claudia H. Kawas, M.D. Neurobiology and Behavior
RESEARCH DESCRIPTION: Have you ever wondered how people live past 100? Or why some people get Alzheimer’s disease when others are spared? The 90+ Study is a longitudinal study of aging and dementia that focuses on the brain changes associated with extreme aging and the factors that can increase or decrease risk of dementia. Work in this study is primarily done off campus. Students will do clerical tasks such as filing, scanning documents, and light computer work, while getting exposure to clinical research. You are responsible for your own transportation to and from the office in Laguna Woods (about 20 minutes from the UCI campus). REQUIREMENTS TO PARTICIPATE COURSE COMPLETION:Bio Sci 194 and Bio Sci 94 GRADE POINT AVERAGE: 3.0 or better TIME COMMITMENT PER WEEK: Variable NUMBER OF UNITS REQUIRED: Variable OTHER: None FACULTY MEANS OF EVALUATION FOR COURSE GRADE: You will be evaluated based on your performance, punctuality and attendance. LOCATION OF RESEARCH: Hewitt Hall, and off campus site in Laguna Woods, CA.
Claudia Kawas: firstname.lastname@example.org, (949) 824-2323
Hans S. Keirstead, Ph.D. Anatomy and Neurobiology,
RESEARCH DESCRIPTION: Bio199 students within the Keirstead lab take part in a variety of different tasks ranging from assisting in surgical procedures such as spinal cord contusion injuries, and intra spinal cellular transplantations to tissue processing, immunohistochemistry and data analysis. Students will often find themselves conducting behavioral tests, summarizing the data into Excel spreadsheets, performing routine post-op animal care and monitoring. These tasks may include administering saline and antibiotic injections intraperitoneally or subcutaneously, daily injections with an immunosuppressant drug, and the quantitative analysis of animal kinematics by analyzing videotaped images. Research will also include tissue dissection, cryostat sectioning, and numerous molecular biology techniques that may include DNA concentration, PCR, electrophoresis, enzyme digestion along with the preparation of cell culture media and gels. Students must be highly motivated, will be expected to dedicate an average of 12-15 hours per week, and must be willing to work on weekends on occasion. Experience in the following areas would be appreciated but not necessary: cryostat cutting and immunological staining, previous animal handling experience or willingness to work with live animals, and previous academic course work in the neurobiology/biology field. LOCATION OF RESEARCH: Gross Hall, School of Medicine, Keirstead Research Group.
Michelle Goldman: email@example.com, (949) 824-5352
Joyce Keyak, Ph.D. Radiological Sciences
Currently not accepting new students. Research involving the evaluation and/or treatment of osteoporosis or metastatic bone disease on a macroscopic, mechanical level. Microscopic or chemical techniques (e.g. gels) are generally not part of this research. Work with cadavers and/or radioactivity may be required.
Joyce Keyak: firstname.lastname@example.org, (949) 824-9421
Antoine Khoury, M.D. Pediatric Urology
RESEARCH DESCRIPTION: Pediatric Urology Research Program Various Pediatric urology research projects are taken place at UCIMC and CHOC under the direct supervision of Dr. Khoury and his group. Undergraduate students will have the opportunity to participate and gain exposure to clinical trials, basic and animal studies, and surgical education and simulator projects. Student will work directly with pediatric urology residents and fellows. Students will be involved in: swine surgeries (major), clinical data collection, data organization and analysis, literature review, interpretation of results, and weekly research team meetings. Depending on the student’s contribution, he/she will have opportunities to be a co-author on publications and possibly present at conferences. REQUIREMENTS TO PARTICIPATE: – Looking for students interested in learning more about pediatric urology and basic and clinical research tools. COURSE COMPLETION: -PRE-requisite bio. 194S (per 199 requirements). GRADE POINT AVERAGE: Must Maintain a minimum overall 3.25 gpa throughout your research experience. TIME COMMITMENT PER WEEK: 3+ hrs. per unit NUMBER OF UNITS REQUIRED: 4-5 units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: – Attendance, quality of contributions, and peer-evaluation from other lab team members. LOCATION OF RESEARCH: UCI Medical Center and CHOC Orange, CA.
Victor Huynh: email@example.com, (714) 456-8176
Virginia Kimonis, Pediatrics
RESEARCH DESCRIPTION: Dr. Virginia Kimonis is the new chief of the Division of Genetics and Metabolism in the Department of Pediatrics at UCI. While involved in many aspects of clinical genetics and clinical research (multicenter clinical NIH studies involving natural history and genotype- phenotype studies in Prader-Willi and Craniosynostosis syndromes), she has an international reputation for her clinical and laboratory research work in inherited muscle diseases that occur in combination with diseases of bone and/or dementia (also known as IBMPFD) Her group localized the gene for the disorder to chromosome 9, identified the causal gene as VCP (CDC48 or p97) and are now identifying the key pathways and functions that are disrupted by the mutations they have found in the affected families. They are also developing a knock-in animal model of the disorder and are working on developing better clinical evaluations, diagnostic testing and treatments for families with IBMPFD, but also for those with other sporadic and hereditary diseases that share components of IBMPFD. OFFICE LOCATION: Hewitt Hall, Irvine and Tower Bldg, Orange
Virginia Kimonis: firstname.lastname@example.org, (714) 456-5791 or (949) 824-0571
Allen Kong, M.D. Surgery, Division of Trauma/Critical Care/Burns
Trauma Research Associates Program (T-RAP) – The T-RAP is a newly created program that is focused on facilitating clinical research in the Department of Surgery’s Division of Trauma/Critical Care/Burns at the University of California Irvine Medical Center (UCIMC) in Orange. T-RAP provides undergraduate students first hand exposure to clinical research in Orange County’s only Level-1 Trauma and Burn Center. The T-RAP experience involves a unique blend of first-hand clinical exposure and scientific research, which should serve useful when applying to medical (allopathic and osteopathic), dental, pharmacy, physician assistant and public health programs around the country. Research associates become well versed in the workings of trauma surgery and critical care as well as patient communication and education. Provides opportunities to watch surgical procedures and attend medical rounds with doctors. Students will be required to attend mandatory Friday meetings at the UCIMC from 12:30-2 PM. Other requirements include: 4 hours/unit per week (3-4 units), a minimum of a one-year commitment to the program (including the summer), and a GPA of >/= 3.0. Email any questions to the program coordinator Bryan Imayanagita at email@example.com To apply for a position please fill out an application at website listed below:
Bryan Imayanagita: firstname.lastname@example.org, (714) 456-5890
Young Jik Kwon, Ph.D. Pharm Sci; Chem Engnring & Materials Sci
RESEARCH DESCRIPTION: Timely, complete, and convenient treatment of many diseases is not yet within reach, although many potent therapeutics have been identified and developed. Successful delivery of therapeutics depends on finding paths toward ideal forms of treatment. In BioTherapeutics Engineering Laboratory (BioTEL) in departments of Pharmaceutical Sciences, and Chemical Engineering and Materials Science tackles this problem by identifying the limitations of current therapeutics and the reasons for those limitations. Target therapeutics are then selected and conjugated in the form of micro- and nanoparticles, using organic chemistry and carrier fabrication tools. BioTEL is currently working to develop drug delivery systems that selectively localize therapeutics in the body, down to the level of cellular compartments, and offer controlled release of therapeutics so that drugs can be delivered only at the desired time. BioTEL employs techniques to immobilize therapeutics, including cancer chemotherapy agents, imaging probes, therapeutic genes and proteins, and cells. Once carriers are localized in a target site through passive and active targeting mechanisms, therapeutics can be triggered to be active by pathological signals. Synthesis of novel carrier materials, innovative fabrication of carriers, elucidation of extracellular and intracellular behaviors of drug/carriers, and development of new drug release mechanisms are the key scientific emphases in BioTEL. Opportunities for undergraduate researchers including nanocarrier synthesis and characterization as well as in vitro and in vivo tests, depending on needs in the lab and qualification of participants. REQUIREMENTS TO PARTICIPATE: Basic molecular biology and organic chemistry COURSE COMPLETION: Sophomore and juniors are ideal but seniors with previous experience will also be considered. GRADE POINT AVERAGE: 3.0 or higher TIME COMMITMENT PER WEEK: Minimum 10 hrs spread through weekdays and weekends NUMBER OF UNITS REQUIRED: 3 or more OTHER: Students with intention of a long-term participation will be given high priority. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Written reports, literature review, presentation in the group meeting, evaluations from graduate co-workers. OFFICE LOCATION: Engineering Tower 944F
Young Jik Kwon: email@example.com, (949) 824-8714
Kimberley D. Lakes, Ph.D. Pediatrics
RESEARCH DESCRIPTION: The National Children’s Study (NCS: www.nationalchildrensstudy.gov) is an observational, longitudinal, community-based population study that will examine the effects of environmental and genetic influences on the health and development of more than 100,000 children across the United States, following them from before birth until age 21. UC Irvine has been awarded a contract to establish a Vanguard Center (a pilot center for the NCS to develop and test the methods for the national study) and conduct the study in Orange County, and contracts to also establish study centers in San Diego County (Wave 1) and San Bernardino County and Kern County (Wave 2), which will follow the Vanguard Center by a year or more. The goal of the study is to improve our understanding of complex interacting processes underlying child development, health, and disease. The study defines “environment” broadly and will take a number of factors into account, including: • Natural and man-made environmental factors • Biological and chemical factors • Physical surroundings • Social factors • Behavioral influences and outcomes • Cultural and family influences and differences • Geographic locations Researchers will analyze the manner in which these factors interact among themselves, and their individual and cumulative influences on children’s health. Studying children over all phases of growth and development will enable researchers to understand the roles of multiple factors on child development, health, and disease. As major discoveries are made throughout the implementation of the study, these findings will be shared with the public. Researchers believe that the NCS will become a rich informational resource for many scientific studies of child health, development, and disease whose results will likely inform future policies and interventions. In April 2009, the NCS launched in Orange County by beginning to go door-to-door in an attempt to find women who are pregnant or might become pregnant in the next 5 years. Our current research efforts are focused on community engagement and recruitment. In addition, we are involved in studies such as: how to evaluate 3-year old children for Autism, screening parents for mental health disorders, and ethical issues related to child participation in genomic research. Student researchers are expected to spend 50% of their time participating directly in community research (through outreach or formative research). Research assignments are based on a number of factors, including student availability and skills as well as project needs. Examples of current activities for student researchers include: • Participation in community outreach, including attendance at community events, distribution of materials about the study in the community, and screening potential participants. • Participation in outreach to the medical community. This may include contacting and distributing study materials to medical practices in the community, analyzing data related to the distribution of births across providers in targeted communities, etc. • Assistance with formative research study involving qualitative data collection (via focus groups and interviews) in the communities. Students will attend and observe focus groups and/or interviews, assisting with data collection. Students will assist with the transcription of meetings and will participate in data analysis and write-up. • Assistance with formative research studies. Examples of current studies include: how to evaluate 3-year old children for Autism, screening parents for mental health disorders, and ethical issues related to child participation in genomic research. REQUIREMENTS TO PARTICIPATE: One-year commitment COURSE COMPLETION: N/A GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: 8-12 hours per week. NUMBER OF UNITS REQUIRED: 2-3 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: • Completion of the UCI IRB Human Subjects and HIPPA tutorials. • Completion of the NCS Research Training. • Reading provided NCS materials and conducting related literature searches. • Reliability and consistency in attendance and documented completion of required hours. • Progress on/contributions to research assignments. • Participation in weekly meetings with research staff. LOCATION OF RESEARCH: 101 Academy Way, Suite 150 Irvine 92617.
Kimberley Lakes: firstname.lastname@example.org, (949) 824-3009
Jonathan R.T. Lakey, Ph.D. Surgery
RESEARCH DESCRIPTION: The focus of my research laboratory is cell and tissue transplantation with specific focus on the transplantation of pancreatic islet cells for those people with insulin dependent diabetes (type I). Over the past few years there have been significant and important advances in the method of human islet isolation allowing the transplantation of isolated islets into patients with longstanding diabetes. Our goal is to develop a clinical islet transplant program at the University of California, Irvine. Additionally, we have an active research program investigating aspects of islet isolation including enzymatic means of tissue dissociation, examining cell tissue energetics and novel methods of validating islet yield and function. To address the key issue of tissue rejection and the need for chronic anti-rejection drugs, we are working with an industrial partner on developing a clinical islet encapsulation program using biocompatible alginate. It is hoped that these pre-clinical transplants and biochemical studies will lead to clinical trials in patients with diabetes. REQUIREMENTS TO PARTICIPATE: General background in biology/biochemistry/immunology. Previous lab courses in biology is strongly recommended. Strong motivation, enthusiasm, good organizational skills, quick study and receptive to taking work direction and working in a team environment. Presentation at scientific meetings along with submission of findings to scientific journals will be encouraged. COURSE COMPLETION: Completion of core through Bio 99 with a grade of B or higher, completion of Bio 194S Safety, consent of instructor. GRADE POINT AVERAGE: GPA 3.0 or higher TIME COMMITMENT PER WEEK: 12-20 hours per week. NUMBER OF UNITS REQUIRED: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Weekly task sign-off sheet and evaluation from staff members in the lab. LOCATION OF RESEARCH: UCI Medical Center bldg 55 rm 160.
Jonathan Lakey: email@example.com, (714) 456-3978
Arthur D. Lander, Ph.D. Dev. & Cell
Role of proteoglycans in mouse brain development. This research is to study the development of the mammalian brain by analyzing mutant mice. The lab has made mutants that lack a proteoglycan, glypican – 1, and which are deficient in brain growth. The goal is to determine what cellular signals are disrupted by this mutation. Methods will include tissue histology, molecular biology, and mouse genetics. Learning how proteoglycans affect brain development in mice will ultimately contribute to the understanding of human birth defects and diseases. Requirements: minimum of 10 hours per week, has a GPA of at least 3.4, preferably has junior standing (but will consider sophomores with excellent grades), and is interested in continuation of this project in future quarters.
Arthur Lander: firstname.lastname@example.org, (949) 824-1721
Jaime Landman, M.D. Urology Research
RESEARCH DESCRIPTION: The significance of advancement in Minimally Invasive Surgery (laparoscopic and robotic) for Urologic applications is of the utmost importance to Dr. Landman and his team. The diversity of this department is immense, and includes: clinical investigations, advanced training for surgeons, animal investigations, environmental sustainability, biomedical engineering for new technology and philanthropy. The student will be expected to assist in study administration and implementation, data collection and data analysis. Depending on the student’s contribution, he/she will have opportunities to be co-authored in abstracts/publications and possibly present at conferences worldwide. REQUIREMENTS TO PARTICIPATE: -Must be at least a 3rd year undergraduate. -Must be willing to commute to the medical center. -Morning availability is preferred. -Please submit CV upon initial contact. COURSE COMPLETION: -PRE-requisite of bio. 194S (per 199 requirement). GRADE POINT AVERAGE: Must Maintain a minimum overall 3.25 gpa throughout your research experience. TIME COMMITMENT PER WEEK: 3+ hrs. per unit NUMBER OF UNITS REQUIRED: 4-5 units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: – Attendance, quality of contributions, and peer-evaluation from other lab team members. LOCATION OF RESEARCH: UCI Medical Center Orange, CA
Victor Huynh: email@example.com, (714) 456-8176
Eva Lee, Ph.D. Biological Chemistry
RESEARCH DESCRIPTION: Eva Lee and her laboratory study genomic instability and cancer etiology. They investigate tissue-specific functions of breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, and interactions between tumor suppressors and endocrines. Her team demonstrated that inhibition of the stabilized progesterone receptor in BRCA1 and p53-mutated mammary epithelial cells prevented or delayed mammary tumors. They continued to focus on the mechanisms of progesterone receptor stabilization as well as the usage of anti-progesterone in breast cancer prevention and progesterone receptor positive breast cancer treatment. How mutations of BRCA genes affect mammary epithelial cell fates and mechanisms of cancer stem cells expansion during the course of chemo-resistance are being studied. The roles of microRNAs are being addressed. In addition, Eva Lee and her laboratory investigate the interaction among checkpoint kinases and DNA repair proteins in the maintenance of genomic stability. Her team demonstrated functional links between ATM and NBS1. They have identified novel mediator, Cep164, for the ATM and ATR signaling pathways that guard genomic stability. How Cep164 function in primary cilia and checkpoint related to degeneration seen in the patients are being investigated. REQUIREMENTS TO PARTICIPATE: lab courses or previous lab experience COURSE COMPLETION: Biology course; Molecular biology & Genetic courses preferred GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: minimum 4 hrs. NUMBER OF UNITS REQUIRED: optional. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: participation and efforts. LOCATION OF RESEARCH: Sprague Hall 140
Eva Lee: firstname.lastname@example.org, (949) 824-9766
Thay Q Lee, Ph.D. Orthopaedic Surgery
RESEARCH DESCRIPTION: Biomechanical Characterization of Diarthroidal Joints. Various human joints will be mechanically tested to quantify the structural integrity of normal and reconstructed joints. The student will participate by assisting Orthopaedic surgeon fellows, residents, postdoctoral fellows, graduate students or medical students. REQUIREMENTS TO PARTICIPATE: Must be a junior or higher and approval by the PI. COURSE COMPLETION: Academic quarter GRADE POINT AVERAGE: Minimum GPA of 3.2 TIME COMMITMENT PER WEEK: 12 hours NUMBER OF UNITS REQUIRED: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Final written report and Powerpoint presentation. LOCATION OF RESEARCH: VA Long Beach HCS Orthopaedic Biomechanics Laboratory (09/151) 5901 East 7th Street, Long Beach, CA 90822 Building 139, Rm 112.
Michelle H. McGarry, MS. Laboratory Manager: email@example.com, (562) 826-5122
Wen-Hwa Lee, Ph.D. Biological Chemistry
RESEARCH DESCRIPTION: Wen-Hwa Lee’s laboratory has several exciting ongoing research projects in basic breast cancer biology and early-stage cancer drug discovery. They investigate the transcriptional roles of breast tumor suppressor, BRCA1, and its functional networking with several important transcriptional regulators during mammary development and differentiation. His team has demonstrated that BRCA1 together with its binding partners ZBRK1 and CtIP is critically important for mammary epithelial differentiation and for suppressing malignant cell phenotypes in cultured cell and mouse models. Their focus is on the mechanisms of transcriptional regulation and genome-wide landscape of BRCA1 target genes using molecular biological approaches and large scale DNA sequencing coupled with bioinformatics tools. In addition, the laboratory is actively involved in cancer drug research. The team has successfully identified a few cancer-inhibiting small chemicals, and is now characterizing derivative compounds using models of several cancers including breast cancer and leukemia. REQUIREMENTS TO PARTICIPATE: lab courses or previous lab experience COURSE COMPLETION: Biology course; Molecular biology or Genetic courses preferred GRADE POINT AVERAGE: 3.2+ TIME COMMITMENT PER WEEK: minimum 4 hrs. NUMBER OF UNITS REQUIRED: optional. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: participation and effort. LOCATION OF RESEARCH: Sprague Hall 140.
Patricia Lim: firstname.lastname@example.org, (949) 824-2718
Charles Limoli, Radiation Oncology
RESEARCH DESCRIPTION: My work is focused on understanding how radiation-induced changes in redox state impact genomic instability, cell survival, and stem cell fates in tissues from the brain, bone and skeletal muscle. My laboratory has shown that irradiation leads to a myriad of cellular changes, but perhaps the most intriguing are the changes to redox state that can lead to oxidative stress. Radiation-induced oxidative stress varies in magnitude and duration, and is generally more dose responsive at earlier post-irradiation times. In multipotent neural stem and progenitor cells, we have shown that sparsely and densely ionizing radiations elicit an acute and chronic oxidative stress. Reactive oxygen (ROS) and nitrogen (RNS) species are involved and can be linked to changes at the mitochondrial level as well as membrane based oxidases. Oxidative stress in neural cells exhibits both adaptive and bystander responses, and is responsible for altering lineage development and radiosensitivity. In neural (as well as many other cell types) we have shown that chronic oxidative stress can be linked to increased apoptosis, and genomic instability involving a wide range of aberrant phenotypes. Mechanistic links between oxidative stress and cancer are becoming increasingly evident, as is the role of reactive species dictating the repair and remodeling of irradiated normal tissue. Other work is involved with directing the fate of multipotent cells (including hESCs) in specific microenvironments, and how that can be further manipulated through genetic and pharmacologic interventions. REQUIREMENTS TO PARTICIPATE: Undergraduate major in natural/physical sciences, Interview, 1 yr commitment COURSE COMPLETION: Certain upper division coursework (flexible) GRADE POINT AVERAGE: ~3.5 TIME COMMITMENT PER WEEK: 12-24h (12h minimum) NUMBER OF UNITS REQUIRED: 3-5 OTHER: Motivated, willingness to learn and work hard FACULTY MEANS OF EVALUATION FOR COURSE GRADE: 1) Research results -Data quality -Productivity 2) Ability to communicate (oral) -Data presentation -Knowledge and scope of research project 3) Ability to communicate (written) -Preparation of methodologies and resultslts. OFFICE LOCATION: Medical Sciences B (811 on campus map), Room B149
Charles Limoli: email@example.com, (949) 824-3053
Haoping Liu, Ph.D. Department of Biological Chemistry
RESEARCH DESCRIPTION: Our research focus on signal transduction and regulation in gene expression that govern phenotypic switching in the yeast Candida albicans. Molecular biology, genetics, and cell biology techniques will be used in our studies. REQUIREMENTS TO PARTICIPATE: Student beginning in summer and continuing through the year will be given preference. Students with prior laboratory experience will also be given preference. COURSE COMPLETION: Completion of the first 2 years of Bio Sci Core or equivalent course is required. GRADE POINT AVERAGE: 3.0 or higher TIME COMMITMENT PER WEEK: 10 hours per week NUMBER OF UNITS REQUIRED: 3 OTHER: Students are strongly encouraged to participate in the Excellence in Research Program, the University Research Opportunity Program (UROP) and the Summer Undergraduate Research Program (SURP). FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Research presentation in lab meetings. LOCATION OF RESEARCH: Medical Sciences I.
Haoping Liu: firstname.lastname@example.org, (949) 824-1137
Melissa Lodoen, Ph.D. Molecular Biology and Biochemistry
RESEARCH DESCRIPTION: My research examines the interaction between the immune system and the parasite pathogen Toxoplasma gondii. T. gondii infects approximately one third of the human population worldwide and causes a lifelong chronic infection. The projects in my lab focus on defining the molecular mechanisms by which T. gondii modulates host immune responses during acute infection. Specifically, we are investigating the pathways by which T. gondii alters the expression of receptors and ligands on the surface of infected immune cells, including monocytes, macrophages, and dendritic cells. We are also working to determine how altered receptor expression affects the ability of infected cells to communicate with other cells in the environment. The goal of these studies is to gain insight into how T. gondii modulates mechanisms of host defense. REQUIREMENTS TO PARTICIPATE: Highly motivated second or third year Biological Sciences students committed to at least two years of research. Attendance and participation in weekly lab meetings is expected. GRADE POINT AVERAGE: 3.5 or higher TIME COMMITMENT PER WEEK: At least 12 hours/week FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Demonstration of initiative, effort, research progress, and quality of written and oral (one presentation in lab meeting each quarter) presentation. LOCATION OF RESEARCH: 3336 McGaugh Hall.
Melissa Lodoen: email@example.com, (949) 824-7805
John Longhurst, M.D./Ph.D. Cardiology
Investigates the neurophysiological mechanisms involved in autonomic reflexes including cardiovascular and acupuncture related mechanisms. Also studying the role of mechanical factors and metabolic products such as bradykinin in stimulating ischemically and reperfusion-sensitive cardiac sensory nerves. These nerves are responsible for angina and a number of other reflexes that lead to hypertension in the immediate post-bypass period, arrhythmias, hypotension, nausea and vomiting. Upper division students who have had introductory physiology/neurophysiology course; 3 quarter commitment. However, year 2 Bio. Majors considered. Students will be involved in whole-animal surgical procedures and histological procedures prefer students who can commit to at least 2-3 hour time blocks. At lest 6 hours/wk. GPA 3.0.
Stephanie Tjen-A-Looi: firstname.lastname@example.org, (949) 824-5602
Shahram Lotfipour, M.D., MPH Emergency Medicine
RESEARCH DESCRIPTION: The EMRAP program, created in 1997, is focused on facilitating clinical research in the Department of Emergency Medicine (EM) at the University of California Irvine Medical Center (UCIMC) in Orange. EMRAP provides undergraduate students first hand exposure to clinical research in the active Level 1 Trauma Center Emergency Department. They will learn to enroll patients in clinical research as well as become very familiar with research methodology. EMRAP didactic and research content also has a public health emphasis. While participating in EMRAP, research associates have an extensive opportunity to interface, inform and educate, and dialogue with patients regarding any one of a number of exciting clinical research studies underway in the department. Every EMRAP research associate plays a vital part in the implementation and maintaining the integrity of research protocols. Interested Spanish speakers are encouraged to email the student coordinators as well as completing the online application. The EMRAP Associate Director is Dr. Bharath Chakravarthy. For more information and the online application, please visit our EMRAP website at http://126.96.36.199/emrap/index.cfm. REQUIREMENTS TO PARTICIPATE: Mandatory Monday night meetings at the UC Irvine Medical Center from 7-8:30 PM, a minimum of one- year commitment to the program (including the summer and breaks). Students must be an undergraduate student or UC Irvine School of Medicine post-baccalaureate students and complete the online application at our website. COURSE COMPLETION: Bio 194S GRADE POINT AVERAGE: 3.0+ TIME COMMITMENT PER WEEK: 4 hour shift / unit per week and Monday 7 PM research meetings NUMBER OF UNITS REQUIRED: Minimum 3 units and max 4 units OTHER: Many EMRAP alumni have successfully entered Medical school, however, EMRAP applicants are invited from all disciplines at UC Irvine. Alumni have also been successful in pursuing Master of Public Health, Physician Assistant, Pharmacy, Optometry, and graduate schools in the basic and social sciences. You can refer to http://students.bio.uci.edu/bio199.html for further bio 199 information. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Components include on-time attendance, participation, presentation, deliverables, and professionalism. Please see EMRAP syllabus for detailed grading information. LOCATION OF RESEARCH: Emergency Department at UC Irvine Medical Center in the City of Orange.
Student Coordinators: email@example.com, (714) 456-2326
Ira T. Lott, M.D. Pediatrics
RESEARCH DESCRIPTION: Project 1: Development, Aging and Dementia in Down Syndrome: The objective of this project is to understand the relationship between Alzheimer disease, dementia and Down syndrome. The research is supported by the NIH. Students will have the opportunity to participate in clinical research trials and will have the opportunity for direct patient contact. Students will also assist in database management and will be trained to administer several neuropsychological tests. Students with a major in the biological sciences and a strong interest in clinical research are preferred. There is potential for independent research projects and publication. Contact Eric Doran, M.S.; firstname.lastname@example.org or (714) 456-8443. Project 2: Developmental Disabilities and Psychoactive Medications: This objective of this project is to assess the use of psychoactive medications in a community based population of individuals with developmental disabilities. The project is supported by the State of California, Dept of Developmental Disabilities. The assessment process consists of: 1) Evaluation of a computerized pharmacy database for consumers living under the supervision of the Regional Center of Orange County; 2) An interdisciplinary clinical team to evaluate consumers who have severe neurobehavioral disorders and are receiving polypharmacy. The student will assist in database management and will be trained to administer some psychological tests assessing behavior and adaptive functioning. Contact: Christy Hom, Ph.D.: email@example.com or (714) 456-2927. REQUIREMENTS TO PARTICIPATE: Must be reliable, self-motivated and enthusiastic COURSE COMPLETION: Commitment of 1 academic year is preferred GRADE POINT AVERAGE: 3.0 or better TIME COMMITMENT PER WEEK: Variable NUMBER OF UNITS REQUIRED: Variable FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work performed and participation
Catherine Loudon, Ph.D. Ecology and Evolutionary Biology
RESEARCH DESCRIPTION: Biomechanics, physiology, and sensory ecology of insects. Undergraduate researchers have worked on a variety of projects including investigating the mechanical properties of insect antennae and mechanics of locomotion in insects. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work. LOCATION OF RESEARCH: office location 5215 McGaugh Hall.
Catherine Loudon: firstname.lastname@example.org, (949) 824-0371
Michael Louie, M.D. Urology
Endourology lab. Multiple large animal surgical experiments as well as other “bench top” experiments in progress on an ongoing basis. Usually the student is assigned a project as primary research and also participates in all of the other experiments as well. Part of the job involves setting up and breaking down the lab for animal experiments and working with the animals (pigs, rabbits) directly after appropriate training. The level of responsibility is graded depending on the experience level of the student and increases as time goes on. A.) Tissue bioengineering: bladder replacement b.) Prosthetics and other surgical materials: bladder replacement, stent development c.) New technology for laparoscopic surgery d.) Studies on endoscopes e.) Clinical research into laparoscopic surgery outcomes in Urology Science back ground and interest in surgical research. No prerequisites. 4-10 hours/wk. GPA 3.25 or above.
Reza Alipanah: email@example.com, (714) 456-6109
Ulrike Luderer, M.D., Ph.D. Medicine
RESEARCH DESCRIPTION: Research in my laboratory centers on the mechanisms by which chemical toxicants damage the ovary, potentially causing infertility and ovarian cancer, and in understanding differences in ovarian susceptibility to toxicants. We are particularly interested in oxidative stress as a mechanism of ovarian injury and in the modulation of susceptibility to ovarian injury by biotransformation enzymes and antioxidants. Work in my laboratory has demonstrated roles for oxidative stress in mediating both spontaneous and toxicant-induced apoptosis in granulosa cells of ovarian follicles. Many known ovarian toxicants are conjugated by the tripeptide glutathione (GSH), and GSH is also a critical detoxification mechanism for reactive oxygen species. We showed that GSH depletion in cultured follicles reversed the protective, suppressive effect of follicle stimulating hormone on reactive oxygen species and on apoptosis. Our work suggests that the protective effects of follicle stimulating hormone are mediated in part via upregulation of GSH synthesis. Using cultured follicles and granulosa cells, we have shown that increased generation of reactive oxygen species is an early event in the induction of apoptosis by polycyclic aromatic hydrocarbons, by the anticancer drug cyclophosphamide, and by ionizing radiation, that depletion of GSH sensitizes to these agents, and that GSH supplementation is protective. Recently, we showed that oxidative damage increases and antioxidant gene expression decreases in the ovary with aging, suggesting that oxidative stress may play a role in ovarian aging. Ongoing studies are using genetically modified mouse models with specific deficits in GSH synthesis or with more globally decreased antioxidant and biotransformation capacity to understand the roles these play in ovarian susceptibility to toxicant-induced ovarian damage, ovarian aging, and ovarian cancer. REQUIREMENTS TO PARTICIPATE: Motivation, enthusiasm. Sophomore or Junior, 3.5 GPA, minimum commitment of 1 academic year, 2 years preferred, 10-16 hours per week minimum, willing to work occasional weekends, willing to work with mice, attend weekly lab meetings and present research in lab meetings. COURSE COMPLETION: GRADE POINT AVERAGE: 3.5 or better TIME COMMITMENT PER WEEK: 10-16 hours NUMBER OF UNITS REQUIRED: 3 to 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Presentations in lab meetings, understanding of topic, reliability, effort put into work. OFFICE LOCATION: 5201 California Avenue, Suite 100.
Ulrike Luderer: firstname.lastname@example.org, (949) 824-3389
Hartmut (Hudel) Luecke, Ph.D. MB&B, Physiology & Biophysics, Computer Science
RESEARCH DESCRIPTION: The main focus of my laboratory are structure-function investigations of integral membrane proteins. To date the atomic structures of less than 250 membrane proteins are known (vs. over 70,000 for soluble proteins). This is in stark contrast to the fact the most genomes contain 20-30% membrane proteins. Recently, we have solved the atomic resolution structure of the light-driven ion pump bacteriorhodopsin (BR) in the resting state at atomic resolution. Together with the structures of several photocycle intermediates “frozen in mid-stroke” we have been able to develop a detailed atomic mechanism of light-driven ion pumping. In addition, the structures of a related membrane protein that serves as the primary receptor in archaeal phototaxis (sensory rhodopsin) and that of a photoreceptor from Anabaena, the first eubacterial rhodopsin structure, have been determined. Another area of interest is structure-based drug discovery. A) We are studying annexins, a family of proteins that interact with phospholipid bilayers in a Ca2+-dependent manner. Annexins are involved in cancer and have been reported to mediate membrane aggregation and fusion, as well as ion channel formation. Detailed structural studies of annexins are essential for understanding their fusogenic and ion channel forming properties at the atomic level. B) We have recently solved the structure of a key enzyme in purine metabolism, inosine-5′-monophosphate dehydrogenase (IMPDH). IMPDH catalyzes the NAD-dependent conversion of IMP to XMP which in turn is converted to GMP, an essential building block of DNA. The IMPDH-reaction is the rate-limiting step in GMP synthesis and is thus a promising target for anti-parasitic and anti-bacterial drugs. We are currently focusing on IMPDHs from P. falciparum, M. tuberculosis , and T. foetus. C) p53, the well-known tumor suppressor, is another target. Due to the techniques we use we require a long-term commitment (ideally two years). Most projects will include setting up crystallization trials – often resulting in a paper if diffracting crystals are obtained. REQUIREMENTS TO PARTICIPATE: 2-year commitment, participation in Honors / Research Excellence program strongly advised, writing of UROP/SURP proposals required COURSE COMPLETION: 97, 98, 99 with A- or better GRADE POINT AVERAGE: 3.5 or better TIME COMMITMENT PER WEEK: 12-15 hours NUMBER OF UNITS REQUIRED: 3-4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Participation, UROP/SURP proposals/poster. LOCATION OF RESEARCH: SH520/530/540.
Hudel Luecke: email@example.com, (949) 824-1605/1797
Ray Luo, Ph.D. Molecular Biology & Biochemistry, Biomedical Engineering
RESEARCH DESCRIPTION: We rely on computational approaches to study structures and functions of biomolecules. Our final goal is to interpret the structural and functional information encoded in genomes and to understand life at the most fundamental level based on physical and chemical principles. Our current research focuses on developing reliable and efficient methods to study biomolecular structures, functions, and intermolecular interactions at atomic detail, and applying our new methods to understand and predict the relations between the sequences, structures and functions of these molecules. Students may choose to focus on the following two general areas of research in the lab. Protein Folding Mechanism and Structure Prediction The ability of proteins to perform various biological functions is attributed to their unique three-dimensional structures which are predetermined by their amino acid sequences. The amazing feat that these molecules have to accomplish to assemble themselves quickly and reliably has puzzled scientists in many different fields for decades. The so-called protein folding problem involves the fundamental issue to understand the folding mechanism and the challenging final goal to predict three-dimensional structures from amino acid sequences. It is often regarded as the second half of genomics. Protein-Protein and Protein-Ligand Interactions Structure determination is only the first half of biochemistry. Function annotation is the other more important half. This requires that we study how biomolecules interact with each other and how such interactions assist functioning. The knowledge is often helpful, sometimes critical, in developing new medicines. Computational studies on intermolecular interactions can provide many insights to the understanding. Computational findings are also much easier to be converted into new virtual compounds which may eventually lead to new drugs. REQUIREMENTS TO PARTICIPATE: COURSE COMPLETION: Bio99 TIME COMMITMENT PER WEEK: 10 hours FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Effort, i.e. research time in the lab, is evaluated for grade in the first quarter. Quarterly presentations will be evaluated for grades in the later quarters.
Ray Luo: firstname.lastname@example.org, (949) 824-9528
Z. David Luo, M.D./Ph.D. Anesthesiology
Gene Regulation & intracellular signaling pathways contributing to pain transduction. Use of animal models mimicking human pain inducting conditions, such as nerve injury and bone cancer, to identify potential target genes and pathways, and study their regulation in sensory neurons and spinal cord and their relationship to pain development under these pathological conditions. Small animal surgery, behavioral pharmacology, cellular and molecular biology techniques, including fluorescent microscopy, gene chip experiments, and transgenic/knock out mice, are utilized in studies. Currently characterizing several genes and signaling pathways that may play important roles in neuropathic pain (pain derived from nerve injury) and cancer pain processing. Required: completion of basic courses of biology, cellular and molecular biology or animal physiology or computer science with a GPA of B or higher, three letters of recommendation. At least 1 year commitment. Selection: academic achievements, experience, enthusiasm, self-motivation.
Z. Luo: email@example.com, (714) 456-7962
Gary Lynch, Ph.D. Anatomy & Neurobiology
RESEARCH DESCRIPTION: The main goal of our research is to discover the mechanisms behind learning and memory. Our lab focuses on rat behavior. Various learning paradigms are used to examine different types of learning and how they manifest in the hippocampus, the theorized site of memory formation. The rat brain is dissected and processed for microscopic imaging and analysis, and this information is used to help further our understanding of the complex pathways that lead to memory formation. REQUIREMENTS: Students must have a minimum of 3.0 GPA and be available for at least 10 hours per week, either mornings and/or afternoons on a consistent schedule in order to handle animals and help run behavioral experiments. Completion of the Bio194S Lab Safety course is required, and a multi-quarter commitment is preferred. Students should be comfortable handling animals (training is provided). We are looking for open-minded students who are willing to learn and contribute their own ideas on how to improve on procedures and projects. MEANS OF EVALUATION: Grades will be given based on the quality of work and time and effort committed to the projects. Contact: -Linda Palmer: firstname.lastname@example.org Office location: GNRF 1216 Bench 13
Linda Palmer: email@example.com, (949) 689-7099
Shaista Malik, MD, PhD Department of Medicine, Division of Cardiology
RESEARCH DESCRIPTION: The focus of our research is the role of cardiovascular imaging, such as cardiac CT, in preventive cardiology. We have a current clinical trial in examining the effects of cardiac CT in identifying early coronary artery disease in patients with diabetes. We are also involved in retrospective data analysis on relationship between cardiac plaque on CT and patient risk factors. REQUIREMENTS TO PARTICIPATE: Have completed UCI IRB tutorials on human research and HIPAA TIME COMMITMENT PER WEEK: 3-4 hours a week for each unit of course credit. NUMBER OF UNITS REQUIRED: 2-4 units. LOCATION OF RESEARCH: UCI medical center
Shaista Malik: firstname.lastname@example.org, (714) 456-3868
John Marshall, Ph.D. Neurobiology & Behavior
Research in Dr. Marshall’s lab is directed at (1) the neurobiological bases of chronic drug abuse (cocaine, amphetamine), and (2) factors that facilitate outcome after brain injury relevant to Parkinson’s disease. Both projects use animal models to study brain events contributing to human disease. Undergraduates participate in many ways, including handling and training animals, sectioning and staining tissue, analyzing tissue, and assisting in neurosurgical procedures. Students participating for more than 2 quarters are encouraged to develop projects in which they take more of a lead role.REQUIREMENTS TO PARTICIPATE: Coursework (Bio Sci 110), GPA, motivation to do research, communication skills. COURSE COMPLETION: Bio Sci 110. 15 hours/week. REQUIRED: 9 units. GPA 3.5. Readings will be assigned to supplement laboratory work. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of research, understanding of topic, reliability
John Marshall: email@example.com, (949) 824-6636
Adam Martiny, Ecology & Evolutionary Biology, Earth System Science
RESEARCH DESCRIPTION: My lab works at the interface between microbiology, ocean ecosystem ecology, and global change. In particular, we are interested in understanding the present and future global distribution of marine cyanobacteria and how they will respond to ocean warming. This includes how cyanobacteria will evolve and adapt to new environments. Student projects could include lab work using culturing and molecular techniques (e.g. PCR), DNA sequence analysis, and modeling. REQUIREMENTS TO PARTICIPATE: Students should be prepared to work with other group member as well as develop independent projects and spend at least 10 hours per week on research. A multi-quarter commitment is strongly preferred, and students will be expected to participate in lab activities and meetings. COURSE COMPLETION: no requirement GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: 10 NUMBER OF UNITS REQUIRED: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Grades will be based on time committed to the project and the quality of research. OFFICE LOCATION: 3208 Croul Hall
Adam Martiny: firstname.lastname@example.org, (949) 824-9713
Jennifer Martiny, Ecology and Evolutionary Biology
RESEARCH DESCRIPTION: Our lab investigates the mechanisms underlying microbial diversity patterns and how this diversity affects ecosystem processes such as nutrient cycling. We use culturing and molecular genetics tools to quantify the diversity of microorganisms including bacteria, archaea, fungi, and viruses in a variety of systems such as grasslands and the coastal ocean. Undergraduate projects mostly involve laboratory work, but opportunities exist for fieldwork and computer modeling. REQUIREMENTS TO PARTICIPATE: Bio 194S Saftey & Ethics COURSE COMPLETION: none GRADE POINT AVERAGE: 3.0 minimum TIME COMMITMENT PER WEEK: at least 12 hours NUMBER OF UNITS REQUIRED: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: proposal, weekly meetings, time commitment and quality of research, research report. OFFICE LOCATION: Steinhaus 455
Jennifer Martiny: email@example.com, (949) 824-0487
Elspeth McDougall, M.D. Urology Research, Education
RESEARCH DESCRIPTION: The significance of training competent physicians is of utmost importance to Dr. McDougall and her team. Her research focuses on novel surgical teaching methods, including the use of virtual reality surgical simulators, particularly in the field of Minimally Invasive Urologic Surgery (laparoscopic and robotic surgery). The student will be involved in surgical education research projects at the UCI Medical Center Surgical Education Center (SEC) and will be expected to assist in study administration and implementation, data collection and data analysis. The student will be working closely with the educational fellow and the SEC lab manager and will have opportunities to work with the da Vinci robot, VR simulators, assist during pig and human cadaveric surgeries, as well as observe live surgical cases in the operating room. The student may be a co-author on manuscripts depending on the level and quality of work and analysis produced during his/her time as part of the research team. REQUIREMENTS TO PARTICIPATE: -Must be at least a 3rd year undergraduate. -Must be willing to commute to the medical center. -Morning availability is preferred. -Please submit CV upon initial contact. COURSE COMPLETION: -PRE-requisite of bio. 194S (per 199 requirement). GRADE POINT AVERAGE: Must Maintain a minimum overall 3.25 gpa throughout your research experience. TIME COMMITMENT PER WEEK: 3+ hrs. per unit NUMBER OF UNITS REQUIRED: 4-5 units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: – Attendance, quality of contributions, and peer-evaluation from other lab team members. LOCATION OF RESEARCH: UCI Medical Center Orange, CA
Victor Huynh: firstname.lastname@example.org, (714) 456-8176
James L. McGaugh, Neurobiology & Behavior
RESEARCH DESCRIPTION: Purpose: Research project is designed to document and study individuals who have extraordinarily superior memory. Students will conduct research with individuals who have indicated they have superior memory abilities. Research will include administration of questionnaires to participants over the phone. These questionnaires are designed to assess subjeces’ knowledge of public, historical, and/or autobiographical events. The questionnaires are lengthy and must be given in a standardized way. Students therefore must be personable and able to communicate clearly and effectively the purpose of our research and the instructions of these quizzes. Students are assigned multiple participants at a time and are responsible for keeping track of appointments and scoring the quizzes they administer. Organizational skills are therefore a must. Students will be required to organize participant information as well as score quiz scores and put into the lab database. After students become comfortable administering quizzes they will be required to train new undergraduate researchers. The ability to communicate with and effectively pass down to peers knowledge acquired in the lab is required. Students are also required to attend a weekly meeting in which they must prepare a short presentation on their contributions to the project, their progress throughout the week and an update of results they have acquired. General discussion about the lab and the project will take place at this time as well. COURSE COMPLETION: Bio 194s GRADE POINT AVERAGE: 3.5 TIME COMMITMENT PER WEEK: Six or more hours per week on the project. NUMBER OF UNITS REQUIRED: 2-3 units OTHER: Open only to 1st, 2nd and 3rd year students FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Students will be evaluated based on performance, punctuality and attendance. LOCATION OF RESEARCH: Qureshey Research Laboratory.
Nan Collett: email@example.com, (949) 824-5401
Dan Mercola, Pathology and Laboratory Medicine
RESEARCH DESCRIPTION: Our lab is involved in studying the study of gene regulation by transcription factors important in cancer using high throughput methods. One example is the role of immediate early genes in prostate and breast cancer. Early growth response 1 (Egr1) is a transcription factor that is over-expressed in prostate cancer. Our goal is to understand the role of Egr1 in prostate cancer. We have done ChIP on chip (promoter array) studies to identify targets of Egr1 in UV irradiated prostate cells. The results show that various Egr1 mediates the coordinated expression of gene down stream of the EGF receptor and includes genes involved in apoptosis, and cell cycle regulation, as well as from the cytokine family. Genes regulated by Egr1 were validated using conventional immunoprecipitation, gene expression and SiRNA studies. The 199 research will consist of studying some of these target genes and their role in stress response and response to EGF. The project will involve extraction and purification of total protein and RNA from prostate cancer cells after treating these cells with various stress stimuli. Then the expression levels of individual proteins and gene transcripts in these samples will be measured by western blotting and real time (quantitative) RT-PCR using highthroughput methods. A final aspect of the project is to summarize and prepare the results. REQUIREMENTS TO PARTICIPATE: provide resume including all summer and other employment and volunterr activity to D. Mercola COURSE COMPLETION: Presentation at term end at a regular laboratory meeting. GRADE POINT AVERAGE: G.P.A. of 3.0+. TIME COMMITMENT PER WEEK: 12 hours/week per quarter NUMBER OF UNITS REQUIRED: Four OTHER: Other projects suitable for 199 participation include chip-on-chip analysis of transcription factor regulation in cancer using lab-developed and commercial promoter arrays, analysis of mechanism of Herceptin action in breast cancer, and bioinformatics analysis of cell-specific gene expression in prostate cancer. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Term end presentation, lab notebook completeness, participation as coauthor in lab study if any, attendance record. OFFICE LOCATION: C-238, Med Sci1
Dan Mercola: firstname.lastname@example.org, (949) 824-1298
Raju Metherate, Neurobiology & Behavior
Neurophysiology of auditory cortex. Requirements to participate: interest in subject area. Units and hours varies. GPA 3.0 or better.
Raju Metherate: email@example.com, (949) 824-6141
Frank Meyskens, Jr., M.D.,F.A.C.P. Comprehensive Cancer Center
My laboratory investigates the biology of human melanoma and the factors that contribute to its etiology and progression Current work is focused on redox-responsive transcription factors and the contribution of heavy metals 3units 12hrs/week GPA 3.0 Experince with cell culture desireable
Frank Meyskens: firstname.lastname@example.org, (949) 824-9267
Sabee Molloi, Ph.D. Radiological Sciences
Research opportunity is available in a medical imaging laboratory in the area of cardiovascular imaging. The learning opportunities include image and data acquisition, image processing, 3-D reconstruction and data analysis techniques. You can also participate in the development of our new medical imaging devices. Students can also be involved in whole-animal surgical procedures. Some background in hardware or software and a strong motivation to learn and participate in research projects are essential. Knowledge of programming languages such as Java, C++ is an asset.
Sabee Molloi: email@example.com, (949) 824-7854
Edwin S. Monuki, M.D./Ph.D. Pathology, Developmental & Cell Biology, Stem Cell Research Center
Forebrain development with focus on the molecular and cellular basis of cerebral cortex and choroid plexus development, and related applications using stem cells. Experimental systems involve mouse genetics, primary explant and dissociated cell cultures, and mouse and human embryonic stem (ES) cell cultures. Projects related to neurodegenerative disease (Alzheimer’s disease), bioengineering (CNS tissue engineering), cell transplantation, and bioinformatics are also available. Requirements to participate: Drive, motivation, enthusiasm, interest, and intellect. Team player, but desires independent project. Attends and presents at lab meetings. Minimum 1.5 year commitment; summers optional. Biology and/or chemistry wet lab experience required; previous lab experience preferred. Top 25% among peers. Minimum 10 hours/wk during school year.
Edwin Monuki: firstname.lastname@example.org, (949) 824-9604
Kailen Mooney, Ecology &Evolutionary Biology
RESEARCH DESCRIPTION: We use field and laboratory studies to investigate the interactions among insects, how insects affect plants, and how plants affect insects. Our research employs a variety of techniques, including growing of plants and maintenance of insect colonies in the lab and greenhouse, measurement of plant chemical and morphological traits, and sampling and quantification of insect communities in the field. We are primarily interested in students willing to make a one-year commitment. Students who make long-term commitments may have opportunities to conduct summer fieldwork at remote field sites, co-authors a scientific research paper, and conduct an honors thesis. REQUIREMENTS TO PARTICIPATE: Students should be prepared to spend at 6 to 12 hours per week on research in time blocks of at least 2 hours each. While some students may work entirely within the Mooney Lab, those having the means to travel independently to local field sites (within 1.5 miles) will also have the option of assisting in field research.
Kailen Mooney: email@example.com, (949) 824-7852
Tahseen Mozaffar, Ph.D. Neurology
RESEARCH TITLE: Association of Autoimmune Myasthenia Gravis with Autoimmune Graves Ophthalmopathy: A retrospective review RESEARCH DESCRIPTION: The purpose of this study is to review the association of seropositive immune myasthenia gravis with autoimmune Graves’ ophthalmopathy. Both diseases are relatively common and co-exist in some patients. Co-existence of these disorders create diagnostic and therapeutic confusion. The research is clinical, retrospective and requires chart review. HIPAA training is required. REQUIREMENTS TO PARTICIPATE: None, other than having a bio background COURSE COMPLETION: GRADE POINT AVERAGE: 3.0 or higher TIME COMMITMENT PER WEEK: 4-10 hours NUMBER OF UNITS REQUIRED: 2 units minimum. LOCATION OF RESEARCH: 200 S. Manchester Avenue, Ste. 110, Orange CA 92868.
Tahseen Mozaffar: firstname.lastname@example.org, (714) 456-2332
Jorgesh Mukherjee, Ph.D. Psychiatry & Human Behavior
Design, synthesis, and use of novel imaging agents. Targets include various enzymes, receptors and neurotransmitter receptor systems, such as dopamine, serotonin, norepinephrine, acetylcholine, glutamate and others. Applications of imaging agents include use in diagnosis of various pathophysiological conditions, evaluate effects of therapeutic drugs, effects of substance abuse drugs, study in vivo biochemistry for eventual use in human studies.
Jorgesh Mukherjee: email@example.com, (949) 824-2018
Edward L. Nelson, M.D. Department of Medicne, Hematology/Oncology
Dr. Nelson conducts research into mechanisms for eliciting antigen specific, anti-tumor immune responses and methods for translation into clinical trials. Specifically, he is developing strategies for individualized polyvalent tumor-specific immunotherapy that take advantage of immune system dendritic cell biology. Dr. Nelson is one of only a handful of investigators developing anti-tumor immunotherapy strategies using vectors derived from alphaviruses, specifically the VEE replicon system. These replicons exhibit in vivo and in vitro tropism for a subset of professional antigen presenting cells, i.e. dendritic cells. Dr. Nelson has demonstrated very promising results for this immunotherapy targeting a non-mutated tumor associated antigen, the homologue of human Her 2/neu, in an animal model of breast cancer. Dr. Nelson is also investigating “naked DNA” or polynucleotide vaccine (PNV) immunization strategies using a unique plasmid vector designed for anti-tumor immunotherapy applications. Dr. Nelson is principle investigator on several clinical trials of anti-tumor immunotherapy. These trials include studies of the growth factor GM-CSF, which is a requisite trophic factor for dendritic cells, as a biological adjuvant and the additive effect of immunostimulatory DNA with antibody directed therapies, i.e. Herceptin.
Edward Nelson: firstname.lastname@example.org, (949) 824-2860
Stuart Nelson, M.D. Ph.D. Dermatologist Beckman Laser Institute and Clinic
RESEARCH DESCRIPTION: Dr. Nelson’s research focuses on the molecular pathophysiology and therapy of port wine stain (PWS) disease. Specifically, the students will be involved in following projects: (1) pharmacokinetics profile for topical drugs using dermal microdialysis combined with HPLC; (2) the protein and gene expression profiles from dermal vascular system before and after combined treatments of laser and topical drugs; (3) network of neuro-vascular system by the co-culture of endothelial cells and sympathetic neurons. The students will be exposed by the state-of-the-art bio techniques including compartmental culture, real-time PCR, dermal microdialysis, HPLC, etc, as well as to learn to carry out the experiments properly, think the projects critically, and solve the problems independently. REQUIREMENTS TO PARTICIPATE: Biological and Biomedical related majors COURSE COMPLETION: Students can in their second year or after. GRADE POINT AVERAGE: Minimum GPA of 3.0 is required TIME COMMITMENT PER WEEK: 3-4 hours per week is required but the hours can be spread throughout the week. NUMBER OF UNITS REQUIRED: Students can continue the project throughout the year and get units each quarter. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Commitment, attendance, enthusiasm, data analysis. LOCATION OF RESEARCH: Beckman Laser Institute and Clinic.
Wenbin Tan: email@example.com, (310) 819-0243
Ninh T. Nguyen, M.D. Surgery
Ninh T. Nguyen MD FACS- Minimally Invasive and Gastrointestinal Surgery RESEARCH DESCRIPTION: The Division of Gastrointestinal Surgery involves examination of various conditions and treatments affecting diseases of the esophagus, stomach and small intestine along with metabolic/bariatric surgery. Students will be expected to attend weekly clinics on Mondays and Tuesdays, as well as work independently in the office. Students are invited to observe surgery as time permits. Student tasks will include maintaining the research database, statistical analysis, and other research duties as necessary. Ability to learn new applications. Experience with Excel, Access, SPSS, Adobe Premiere, Adobe Photoshop, Adobe Illustrator, Video editing preferred. Must be willing to travel to medical center. Student will be supervised by the PI and the surgical research resident. REQUIREMENTS TO PARTICIPATE: 3.0 overall GPA and sophomore standing COURSE COMPLETION: Bio 194S. Statistics and physiology recommended but not required GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: Approximately 12 hours/week NUMBER OF UNITS REQUIRED: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work, fulfillment of time commitment OFFICE LOCATION: 333 City Boulevard West, Suite 850, Orange, CA 92868 Contact:Katie Teetor, Ninh T. Nguyen MD FACS ; 714-456-8598
Alana Gebhart: firstname.lastname@example.org, (714) 456-7367
Diane O’Dowd, Ph.D. Developmental & Cell Biology
Research: Students will work on projects associated with assessing the effectiveness of specific teaching strategies, both in terms of performance and attitude of undergraduate students, graduate students, and faculty. Students will be involved in formulating hypotheses, designing experiments to be conducted during teaching, and analyzing data we gathered during the previous quarters. Requirements: B or higher in Bio 93 and are able to commit 10 hrs/week.
Diane O’Dowd: email@example.com, (949) 824-4562
MV Pahl, M.D. Medicine
RESEARCH DESCRIPTION: Pathophysiology of renal disease and Hypertension Using cultured cells and rodent models of kidney disease and hypertension, Molecular biological and histological techniques COURSE COMPLETION: Flexible GRADE POINT AVERAGE: Flexible TIME COMMITMENT PER WEEK: minimum 8 hours NUMBER OF UNITS REQUIRED: up to 5 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: observation of the student participation and quality of work. LOCATION OF RESEARCH: Medical Sci C, Room C351.
Madeleine Pahl: firstname.lastname@example.org, (714) 456-5142
Nimisha Parekh, M.D., M.P.H. Medicine/Gastroenterology
Description: Students will be work with patient who have Inflammatory Bowel Disease. The experience will span the spectrum of clinical research, including project design, background literature search, and help recent research or assist in writing an IRB (institutional review board) proposal, enrolling patients in ongoing studies, data compilation or writing/presenting research. Experience as a research associate will be enhanced by being assigned to faculty and staff as liaisons for each project. Wednesday afternoon research meetings will help to monitor progress as well as assist in furthering your research experience. Opportunities for publication and possibly presentation at local and national conferences are available. Requirements would include: -3.5 overall GPA -sophomore standing -two year commitment -Four hours/unit/wk -Minimum of 2 units/4 units with the option for more units upon request -Ability to work independently as well as in a group setting Students will be graded on: -Work performance -Initiative -Quarterly research summary Location: UCI Medical Center and at Gottschalk Plaza
Hannah Lui Park, Epidemiology
RESEARCH DESCRIPTION: Dr. Park is an Assistant Professor in the Department of Epidemiology, School of Medicine. She is the Site Program Director of the Athena Breast Health Network, a UC-wide collaboration to improve clinical care and research for breast health. The UCI Principal Investigator is Dr. Hoda Anton-Culver, Professor and Chair of Epidemiology, and the UCI Athena Team is comprised of a multi-disciplinary group of physicians and scientists, all with the common goal of making a positive impact on breast health. An array of opportunities exist for 199 students to work on a project on breast cancer prevention, screening, diagnosis, treatment, or survivorship under the direct supervision of a clinical or basic science professor. REQUIREMENTS TO PARTICIPATE: Interest in breast health. Attention to detail. Regular meetings with supervisor. GRADE POINT AVERAGE: 3.3 or higher. TIME COMMITMENT PER WEEK: 12 hours per week and a minimum of 2 consecutive quarters. NUMBER OF UNITS REQUIRED: 3 units OTHER: On the last day of instruction of each quarter, students are required to turn in a 1-2 page summary of work completed. This can include background information obtained by reading the literature, details about a technique learned, and/or data generated. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work, data collection, following appropriate lab and university-mandated safety protocols, initiative, and overall enthusiasm for research. LOCATION OF RESEARCH: Depends on location of Faculty Mentor (Sprague Hall, Irvine Hall, or UCI Medical Center in Orange).
Hannah Lui Park: email@example.com, (949) 824-2651
Ian Parker, Ph.D. Neurobiology & Behavior
We are applying advanced imagin methods (confocal, multi-photon and evanescent wave mivroscopy) to study intracelllular calcium signaling processes. Ion channels are mediate the functioning of all cells, including processes such as synaptic transmission and electrical excitation. Moreover, they are implicated in many disease such as schizophrenia, Alzheimer’s diseases, and Parkinson’s, making them important targets for drug therapies. Our laboratory is currently involved in developing new imaging techniques that permit us to visualize the activity of individual ion channels in living cells – something previously possible only by the electrophysiological patch-clamp technique. Positions are available for 2 students to be involved in different aspects of the project. (1) Expression of ion channels in Xenopus laevis oocytes . This will involve learning basic molecular biology techniques such as cell transformation, propagation, in-vitro transcription and gel electrophoresis. (2) Analysis of single channel activity using image analysis and graphing software. Requirements: Sophomore (in exceptional cases) or Junior standing, 3.2 GPA (this is sometimes negotiable), minimum commitment 1 year (3 quarters), 2 years preferred; 8-12 hours per week.
Angelo Demuro: firstname.lastname@example.org, (949) 824-7833
Irene Munk Pedersen, MB & B
RESEARCH DESCRIPTION: The recent discovery of microRNAs (miRs) has revolutionized our understanding of gene control. miRs are encoded by endogenous genes and regulate over half of all genes in mammalian cells. They regulate gene expression at the stages of translation and mRNA stability. Already there is evidence that specific miRs play key roles in controlling development, stem cell fates and differentiation, and mutations in human miR genes have been linked to oncogenic and other disease states. An important task is to unveil the functions of individual miRs, determine how the miRs themselves are regulated and elucidate their role in human diseases. The main focus of my laboratory is to investigate the role of specific miRs (identified from miR/amiR screens) in cancer- and Induces Pluripotent Stem Cell (iPSC)-development, and explore how to regulate/counteract such dysregulation in a diseased state. A second area of research interest of my laboratory is to elucidate miRs function as an anti-viral defense mechanism in humans. LOCATION OF RESEARCH: 3450 MCGAUGH HALL.
Irene Pedersen: email@example.com, (949) 824-2587
Alessio Pigazzi, Department of Colon and Rectal Surgery
Students will be exposed to colorectal surgery, minimally-invasive surgery and surgical endoscopy. Your experience will span the spectrum of clinical research. You might begin a project and help create a study based on recent research or assist in writing an IRB (institutional review board) proposal, enrolling patients in ongoing studies, data compilation or writing/presenting your research. Your experience as a research associate will be enhanced by being assigned to faculty and staff as liaisons for each project you work on. Monday afternoon research meetings will help to monitor progress as well as assist in furthering your research experience. Opportunities for publication and possibly presentation at local conferences are available. REQUIREMENTS TO PARTICIPATE: -3.25 overall GPA -sophomore standing -Monday evening availability (not always necessary) -Attend at least one clinic weekly -one to two year commitment -Four hours/unit/wk -Minimum of 2 units -Ability to work independently as well as in a group setting FACULTY MEANS OF EVALUATION FOR COURSE GRADE: -Work performance -Initiative -Quarterly research summary. OFFICE LOCATION: 333 City Drive South Orange, Ca 92868
Kathrina Munoz: firstname.lastname@example.org, (714) 456-5443
Daniele Piomelli, Ph.D. Pharmacology
The psychoactive effects of 9-tetrahydrocannabinol, the major pharmacological ingredient of Cannabis sativa, are caused by the activation of G protein-coupled membrane receptors called cannabinoid receptors. The expression of these receptors __ abundant in brain structures involved in cognition, emotion and movement __ and the behavioral consequences of their activation __ ranging in man from euphoria to memory deficits __ underscore the potential importance of the endogenous signaling system by which these receptors are thought to be engaged. Yet, the biochemical nature, anatomical distribution and physiological functions of such signaling system remain largely unknown. Understanding the biochemistry and pharmacology of the body’s own cannabinoid system is the major long-term objective of the research in our lab. To progress in this direction, we adopted two complementary approaches. On the one hand, we use biochemical and molecular biological techniques to study the mechanisms of formation and inactivation of endocannabinoid substances. On the other hand, we apply this biochemical information to design drugs that interfere with endocannabinoid metabolism. The development of pharmacological agents that prevent formation or inactivation of the endocannabinoids is essential to understand the physiological functions of these signaling molecules. Such drugs may not only prove to be useful experimental tools, but in light of the multiple behavioral effects of cannabinoid receptor activation might also open novel therapeutic avenues for the treatment of neurological and psychiatric disorders. REQUIREMENTS TO PARTICIPATE: Willingness to learn and excitement about science. 9-12 hours/wk. REQUIRED: 3 units. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work performed and participation.
Fariba Oveisi: email@example.com, (949) 824-6180
Maksim Plikus, Ph.D. Dev & Cell Biology/Stem Cell Research Center
Maksim Maksim, Ph.D., Developmental and Cell Biology / Stem Cell Research Center RESEARCH DESCRIPTION: Dr. Plikus lab is investigating the regenerative potential of skin and the role of adult stem cells in wound healing. His laboratory is working to learn how activities of adult stem cells are regulated and how they can be directed to undergo embryonic-like regeneration events. REQUIREMENTS TO PARTICIPATE: Attendance of lab meetings, Completion of assigned lab safety training COURSE COMPLETION: Bio 194S GRADE POINT AVERAGE: 3.5 GPA TIME COMMITMENT PER WEEK: 12 hours per week NUMBER OF UNITS REQUIRED: Minimum enrollment of 3 units OTHER: n/a. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work and data collection, proper use of lab equipment, following appropriate lab and safety protocols, initiative and enthusiasm. LOCATION OF RESEARCH: 845 Health Science Road, Sue & Bill Gross Hall, #1205. Contact: Maksim Plikus:
Maksim Plikus: firstname.lastname@example.org, (949) 824-1260
Steven G. Potkin, M.D. Psychiatry Research
Current research involves numerous structural and functional MRI, PET, EEG and other imaging studies. Students will be involved in data collection, analysis and visualization, with weekly team meetings to discuss the current projects and interpret results. Looking for research students interested in learning more about brain imaging, brain function and dysfunction. Must have 1 year commitment minimum and 3.0 GPA.
Jessica Turner: email@example.com, (949) 824-3331
Yufen Qin, M.D., Ph.D. Neurology
The goal of our research is to characterize the cellular and molecular immune mechanisms that lead to demyelination and axon loss in patients with multiple sclerosis. We expect that elucidation of these pathological mechanisms will provide new opportunities to prevent and/or delay neuron and axon degeneration in the central nervous system of affected patients. Office location: Med Sci II, 301A and B. Should work for at least 1 school yr. GPA: 3.5+. 12-15 hrs/wk.
Yufen Qin: firstname.lastname@example.org, (949) 824-1641
Manuela Raffatellu, M.D. Microbiology and Molecular Genetics
RESEARCH DESCRIPTION: The goal of our research is to understand how mucosal responses are orchestrated in response to mucosal pathogens such as Salmonella typhimurium. The mucosal immune response has the important function of containing an infection and preventing dissemination of pathogens to systemic sites. However, there is increasing evidence that mucosal pathogens achieve greater colonization during inflammation. We are interested in investigating this dichotomy of the host response and understanding which responses constitute the mucosal barrier during S. typhimurium infection and which favor S. typhimurium colonization of the inflamed gut. Our 199 students will learn basic techniques in Microbiology, Bacterial Genetics, Immunology and Molecular Biology. COURSE COMPLETION: Bio 194S GRADE POINT AVERAGE: 3.0 or better TIME COMMITMENT PER WEEK: At least 15 hours/week, at least 1 school year commitment NUMBER OF UNITS REQUIRED: 4-5 OTHER: Student will be ask to participate to lab meetings and present their research progress at least once a year. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Attendance, Independence, Quality of Benchwork, Lab Book Maintenance, Presentation of results. LOCATION OF RESEARCH: C150 Med Sci I.
Manuela Raffatellu: email@example.com, (949) 824-0359
José M. Ranz, Ph.D. Ecology and Evolutionary Biology
RESEARCH DESCRIPTION: Two positions are offered. Our research interests lie at the interface of functional and evolutionary genomics using Drosophila as a model organism. In particular, we are interested in understanding how the molecular organization of the genome is shaped by functional constraints. We have identified a limited number of genomic regions where gene order has been preserved unexpectedly upon the multiple chromosomal rearrangements that have occurred during the evolutionary process. Those regions can encompass up to 50 genes. We have functionally analyzed those regions and found that they are often enriched for genes with similar functional properties. We are using genetic techniques of chromosomal engineering to disrupt those regions and to evaluate the effect of breaking those ultra-conserved regions of the genome using different genetic and molecular approaches. Specifically, we are performing molecular and physiological tests on individuals with both intact and disrupted regions, which will allow us to compare the gene expression and effects on fitness due to the disruption of those regions. Genomic DNA extraction, RNA extraction, PCR, RT-PCR, microarray experiments, tissue dissection, sequence analysis, data mining, and stock maintenance are the most relevant tasks associated with the projects described here. REQUIREMENTS TO PARTICIPATE 3 quarters minimum COURSE COMPLETION Bio194S, Bio97, Bio99, and at least one among E106, D145, and D146 is advisable. GRADE POINT AVERAGE at least 3.2 TIME COMMITMENT PER WEEK: 12 hours minimum NUMBER OF UNITS REQUIRED: 4 units will be given for 12 hours per week. OTHER: Students interested in performing research in our lab are encouraged to visit the lab prior to requesting a position (http://ranzlab.bio.uci.edu). FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Professionalism (enthusiasm, effort, attendance, high-quality work, team-work attitude) and quarterly research report. OFFICE LOCATION: 465 Steinhaus Hall
José M. Ranz: firstname.lastname@example.org, (949) 824-9071
Rainer K. Reinscheid, Ph.D. Pharmaceutical Sciences
Rainer K. Reinscheid, Ph.D. Pharmaceutical Sciences We study the function of novel neuropeptide systems in anxiety, arousal and sleep by using molecular biology, pharmacology and animal behavior techniques. Our goal is to identify the function of these transmitter systems in healthy brains and their association with brain disorders, such as stress, sleep disorders, memory impairment, drug addiction, etc. Students will have opportunity to participate in experiments covering all aspects of pharmacological research: molecular (cloning) and cellular (cell culture) biology, pharmacology (receptor binding and second messenger assays) and animal behavior (if desired). REQUIREMENTS TO PARTICIPATE: students interested in pharmacological/pharmaceutical research; commitment: 2 years or more. Preference to those with experience in biological and/or chemical techniques. GRADE POINT AVERAGE: 3.3+ TIME COMMITMENT PER WEEK: 8-12 hours/week NUMBER OF UNITS REQUIRED: 2 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: participation, willingness to learn, responsibility OFFICE LOCATION: 310C Med Surge II, School of Medicine
Rainer Reinscheid: email@example.com, (949) 824-9228
Michael Rose, Ph.D. Ecology
Our lab uses experimental evolution and evolutionary physiology as approaches to address basic problems in biology. Fruit flies of the genus Drosophila are our experimental tool. Some of our research topics include the evolution and physiology of aging, cryonic preservation and resuscitation, reverse evolution, and evolutionary convergence in novel environments. We run a large lab in which undergrduates play a central role at every stage of the research process. Requirements to participate: Biology 96 or 106 with minimum grade of B, or Biology 94 with a minimum grade of A-. 3.0 grade point average, 10 hours per week to start.3 units for beginning students. *All research students start as Bio. 198 group research students. Progress to Bio. 199 status depends on the student’s abillity to work independently. NO student begins in the Bio. 199 course. Faculty Means of Evaluation for Course Grade: For 198: successful completion of hours, work assignments, and attendance at lab meetings; progress in understanding the scientfic background to the research. For 199: development of a successful research plan, execution of research plan, scientific understanding, completion of Excellence in Research requirements.
Michael R. Rose,PH.D.: firstname.lastname@example.org, (949) 824-8198
Scott Rudkin, M.D. Emergency Medicine
Requirements: 3.5 overall GPA and junior standing. A minimum of one-year commitment of at least 12 hours/week. Emergency Medicine Workforce Issues: Analysis of factors that limit the willingness of on-call physicians to provide federally mandated emergency care. Emergency Department Efficiency: Investigation of barriers that limit the ability of emergency departments to provide timely emergency department care. Arterial Blood Gas vs. Venous Blood Gas Testing in Trauma patients: Determination whether a venous sample can supplant the need for an arterial source for blood gas testing in critically ill patients. SELECTION CRITERA: Interview. Number of Units/Quarter: Negotiable, based on hour commitment Examination N/A Quality of Work XX Quantity of Work XX
Scott Rudkin: email@example.com, (714) 456-5239
Hamid M. Said, Ph. D., Pharm. D Medicine, Professor and Vice-Chairman for Research.
RESEARCH DESCRIPTION: To study cell and molecular mechanisms involved in the transport of water-soluble vitamins (thiamin, riboflavin, folate, biotin, pantothenic acid, niacin, pyridoxine) in intestinal/renal epithelial cells and in pancreatic beta and acinar cells in health and disease. We also examine regulation of vitamin transport and the effect of chronic alcohol consumption, congenital defects in the transport protein, drug-interactions and effect of dietary factors on vitamin transport processes. Our laboratory is funded by grants from the NIH and other national agencies. Direct involvement of the students in the research projects is expected. REQUIREMENTS TO PARTICIPATE: The student should have completed biology, biochemistry or a related class COURSE COMPLETION: Year round GRADE POINT AVERAGE: No less than 3.0 TIME COMMITMENT PER WEEK: A total of 14-16 hrs per week NUMBER OF UNITS REQUIRED: 3 to 4 OTHER: N/A FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Attendance and actual contribution. LOCATION OF RESEARCH: Long Beach VA Medical Center.
Hamid Said: firstname.lastname@example.org, (562) 826-5811
Ann K. Sakai, Ph.D. Ecology and Evolutionary Biology
RESEARCH DESCRIPTION: Flowering plants have a great diversity of breeding systems. Some species are hermaphroditic, others have females and hermaphrodites, and still others have only males and females. Our lab is interested in factors that promote these different breeding systems and the genetic potential of plants to evolve these different breeding systems. Understanding these processes provides information important in conservation, agriculture, and basic sciences. In a second line of research, our lab is also investigating factors that make non-native plants invasive in our local habitats. Undergraduates are directly involved in research and work closely with faculty and students in the greenhouse and laboratory on the rare Hawaiian genus Schiedea or in the field in local habitats invaded by fountain grass. For further information, check out our website (see below). REQUIREMENTS TO PARTICIPATE: Interest in ecology, conservation and/or evolution; prefer students with more than one year remaining at UCI COURSE COMPLETION: : Bio 94 and 106 (completed or concurrent) with grade of B or better GRADE POINT AVERAGE: prefer minimum GPA of at least 3.0 TIME COMMITMENT PER WEEK: variable but must be willing to work some weekends NUMBER OF UNITS REQUIRED:variable; minimum of 2 units per quarter OTHER: Students interested in the lab should first look at the following website http://www.faculty.uci.edu/profile.cfm?faculty_id=2693 and then send an email to Ann Sakai, indicating which aspects of the research are of greatest interest. Most of our students stay in the lab for at least two years and participate in the Excellence in Research program . OFFICE LOCATION: UCI main campus greenhouse and laboratories, local field sites
Ann Sakai: email@example.com, (949) 824-6581
Curt Sandman, Ph.D. Psychiatry
Evaluating the consequences of prenatal exposure to stress and stress hormones for fetal and infant development. Students working on this project will have the opportunity to work with doctors, nurses, infants and parents. Research assistants collect data at UCI pediatric clinics and at the NICU and newborn nursery at the UCI Medical Center . Spanish speaking students have the opportunity to conduct interviews in Spanish. We are looking for highly motivated students with an interest in medicine, psychology, basic biology, or public health, who are willing to work 10-12 hours/week for a minimum of 1 year. Training will be provided. Students should have access to transportation to and from the Med Center .
Elysia Davis: firstname.lastname@example.org, (714) 957-5535
Suzanne Sandmeyer, Ph.D. Biological Chemistry
GPA should be 3.3 or higher. Science majors. Completion of introductory biology and general chemistry. Genetics, biochemistry or molecular biology lab experience preferred but not essential. Summer: 20 hours per week. Fall: 10-15 hours per week. Prefer one year commitment. Laboratory works on Ty3 which is a retrovirus like element in bakers yeast. Retroviruses are important because they are the causative agent of AIDS and because they are used as gene therapy vectors. They are unique in that they reverse transcribe an RNA genome into DNA and then integrate into the chromosomal DNA. The long term goal of this work is to identify homologues of proteins which are important for retrovirus replication in mammalian cells. These would be potential targets of antiretrovirus therapy.
Suzanne Sandmeyer: email@example.com, (949) 824-7571
Paolo Sassone-Corsi, Ph.D. Pharmacology
The focus of our research has been centered for many years on the mechanisms controlling gene expression. In particular we have explored how specific chromatin remodeling, transcriptional and epigenetic systems govern a number of physiological responses. At least two areas of research are of interest: 1) The circadian clock. 2) The differentiation of germ cells. 1. The Circadian Clock. All aspects of our physiology, including the biological rhythms of feeding, hormonal production, wake-sleep cycles, motorial activity etc are regulated by the circadian clock, a molecular pacemaker based on transcriptional autoregulatory loops. We have been exploring both the physiology and genetics of this system, and unraveled some of the most surprising and fascinating links with chromatin remodeling, cell cycle and metabolism (see for example Cell (2006) 125, 497-508). 2)The differentiation of germ cells. The generation of totipotent stem cells occurs through gametogenesis, a complex, sex-specific differentiation program (for an overview of our interests see Nature (2005) 434: 583-589). Germ cells have the unique capacity to start a new life upon fertilization. The mechanisms of gene regulation in germ cells are highly specialized, and we have identified a number of unique molecular devices that germ cells utilize to elicit a fine control of pre- and post-meiotic transcription. In addition, unique epigenetic modifications exist in germ cells, including a remarkable set of germ cell-specific histone variants and a highly specialized use of DNA-methylation. Their function in chromatin remodeling, meiosis and gene expression is crucial. In the male, the haploid germ cells undergo the spectacular histone-to-protamine transition process which reshapes the nucleus and prepares it for fertilization. The epigenetic control of these processes has a number of outstanding features and its comprehension is likely to have far-reaching implications for human health and reproduction. The unraveling of the regulatory pathways and molecular mechanisms that govern the differentiation program of germ cells is likely to provide essential hints to the biology of stem cells of non-germinal origin. In particular, our studies have identified highly specialized pathways for the control of RNA processing which determine the timing of the differentiation steps leading to germ cells maturation. REQUIREMENTS TO PARTICIPATE: High quality students with optimal scientific knowledge will be selected for their drive and enthusiasm. Interest at working at the bench and natural sense for experimentation are essential. Selection criteria: Resume and interview. Minimum of 1 year commitment. Strong preference will be given to students with a 2 year commitment COURSE COMPLETION: GRADE POINT AVERAGE: 3.0 and higher TIME COMMITMENT PER WEEK: Minimum of 12 hours/week NUMBER OF UNITS REQUIRED: 4 units required OFFICE LOCATION: 2115 Gillespie Neuroscience
Paolo Sassone-Corsi: firstname.lastname@example.org, (949) 824-4540
Catherine Sassoon, M.D. Medicine (Div of Pulmonary & Critical Care)
Catherine Sassoon: email@example.com, (562) 826-5839
Steven Schreiber, M.D. Neurology
Molecular and cellular mechanisms of neuronal degeneration and repair in the central nervous system
Steven Schreiber: firstname.lastname@example.org, (949) 824-1669
Leonard S. Sender, M.D. Department of Medicine,, Division of Hematology-Oncology
RESEARCH DESCRIPTION: Comprehensive investigation of adolescent and young adult (AYA) cancer patients (ages 15 to 39 years). Utilizes a multidisciplinary approach including: epidemiological components (incidence, prevalence, root causes); biological factors (genetic or cellular differences); the psychosocial impact of disease in the population; long-term cancer survivorship including fertility preservation; and service delivery. The inclusive research vision incorporates research from social ecology to address psychosocial difficulties, law and public health to deal with and correct current health policy and education, epidemiology to investigate the role of environmental influences, and biomedical ethics to concentrate on long-term effects of cancer therapy in adolescents and young adults. REQUIREMENTS TO PARTICIPATE: Students must be in their junior or senior year at UC Irvine, in good standing with the University and the School of Biological Sciences, and have, at a minimum, a 3.5 GPA. Students will need to submit a resume, a writing sample, and a statement of interest prior to being considered for a position. Academic interests should match one or more of the research goals of the clinical faculty member. Students should be prepared to participate 3-4 hours for each enrolled unit of Bio 199. Students should be willing and able to work independently on assigned tasks and be able to manage multiple assignments at one time while meeting defined deadlines. Successful candidates should demonstrate a willingness to learn and incorporate methods from other disciplines into their investigation of AYA cancer. COURSE COMPLETION: Interested parties should have passed Bio 194S Safety and Ethics for Research and have completed the electronic research tutorials (HIPAA, human subjects) offered through the UC Irvine Office of Research. Additional environmental health and safety training will be provided as needed. GRADE POINT AVERAGE: Students must have, at a minimum, a 3.5 GPA. Exceptions may be made on a case-by-case basis. TIME COMMITMENT PER WEEK: Students should be prepared to participate 3-4 hours for each enrolled unit of Bio 199. NUMBER OF UNITS REQUIRED: Minimum 2 units; prefer 3 or more units. OTHER: Work location may vary. Students must have reliable transportation as meetings with Dr. Sender are often scheduled in his academic office at UC Irvine Medical Center. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Research presentation and/or publication at the end of each quarter, participation in lab meetings, commitment, and professionalism. LOCATION OF RESEARCH: UC Irvine Medical Center.
Leonard Sender: email@example.com, (714) 456-8025
Donald Senear, Molecular Biology & Biochemistry
RESEARCH DESCRIPTION: Research in the lab focuses on the self-assembly of regulatory protein-DNA complexes in transcription and the control of gene expression. Students will conduct a range of experiments from biophysical analysis of protein structure and dynamics, and protein-DNA interactions to determination of levels of regulated mRNA’s in vivo. REQUIREMENTS TO PARTICIPATE: Minimum 1 year commitment with expectation of second year encouraged strongly. Prefer starting in third year. Preference for students majoring in biochemistry and molecular biology. COURSE COMPLETION: Completion of Bio 99 though have accepted as concurrent. GRADE POINT AVERAGE: >3.0 TIME COMMITMENT PER WEEK: 15 hrs; typically 3 half days per week plus occasionally will be necessary to blend all day experiments with other activities. NUMBER OF UNITS REQUIRED: 4 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Enthusiasm and commitment of the student; quality of the work completed; end of the qtr report. LOCATION OF RESEARCH: MH 3206.
DF Senear: firstname.lastname@example.org, (949) 824-8014
Yongsheng Shi, Microbiology and Molecular Genetics
RESEARCH DESCRIPTION: All eukaryotic mRNA precursors must go through multiple RNA processing steps in the nucleus, including capping, splicing, and 3’-end processing, before being exported to the cytoplasm as mature mRNAs. These mRNA processing steps plays critical roles in post-transcriptional gene regulation. Additionally, alternative mRNA processing is a major mechanism for expanding protein diversity in metazoans. However, the molecular mechanism and regulation of mRNA processing remain poorly understood. The research project will focus on elucidate the fundamental mechanisms mRNA 3’ processing of our lab is mRNA 3’ end processing (cleavage/polyadenylation) by using a combination of genomic, proteomic, biochemical, and bioinformatic approaches. COURSE COMPLETION: Biochemistry GRADE POINT AVERAGE: 3.3 TIME COMMITMENT PER WEEK: 10 hours . NUMBER OF UNITS REQUIRED: 2 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Research progress, dedication, and effort. LOCATION OF RESEARCH: C135C, Medical Sciences I.
Yongsheng Shi: email@example.com, (949) 824-0397
Yao-Yang Shieh, Ph.D. Radiological Sciences
RESEARCH DESCRIPTION: Acupuncture is a major modality for disease treatment in oriental medicine. Clinical evidence suggests that acupuncture is effective for some but not all disorders, but the clinical efficacy of acupuncture remains controversial in the scientific community. Recent neuro-imaging data using functional MRI further indicate that acupuncture at certain body points (acupoints) could activate specific and non-specific areas in the brain. However, different research groups have reported inconsistent results which can be attributed to different experimental designs and technical parameters used. Possible parameters that may affect outcomes include post-treatment residual effect, stimulation pattern, duration of needle retention, sham acupuncture, fMRI image processing & analysis. Our ongoing research work involves experimental analysis for critical design factors and technical parameters that would affect the study outcomes of acupuncture. This analysis can be used to determine whether the methods of a study are sound. The ultimate goal is to establish a standardized protocol so that results from different research groups can be compared and integrated. REQUIREMENTS TO PARTICIPATE: a reasonable knowledge of using computer software to do image analysis. TIME COMMITMENT PER WEEK: 9 to 12 hours per week.
Yao-Yang Shieh: firstname.lastname@example.org, (714) 456-6018
Martin Smith, Ph.D. Anatomy & Neurobiology
RESEARCH DESCRIPTION: Synapse formation and neuronal plasticity. Much of what is known about synapse formation has come from studies of the vertebrate neuromuscular junction where a protein called agrin is responsible for the motor neuron induced differentiation of the postsynaptic apparatus in the muscle fiber membrane. Agrin’s action in muscle is mediated by a receptor tyrosine kinase called MuSK. Agrin is also expressed by neurons in the brain where it may also serve a synaptic function. However, we have shown that agrin’s target on neurons is a sodium pump rather than MuSK, suggesting that agrin’s effects in brain are due to an ability to modulate neuronal excitability by controlling sodium pump activity. Interestingly, this model of agrin action extends to other excitable cells since mutation of the agrin gene is associated with changes in cardiac muscle function. We are using cellular, molecular, biochemical, and electrophysiological approaches to further understand the mechanism of agrin action in neurons and other cells. REQUIREMENTS TO PARTICIPATE: COURSE COMPLETION: B+ or better in Bio 93 GRADE POINT AVERAGE: Minimum GPA of 3.3 TIME COMMITMENT PER WEEK: Minimum of 12 hours/week NUMBER OF UNITS REQUIRED: 4 OTHER: Sophomore preferred FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Student will produce a written summary and make oral presentation of project at the end of each quarter.
Martin Smith: email@example.com, (949) 824-7079
George Sperling, Ph.D. Neurobiology & Behavior
One – two openings. Work with EEG measurements in response to visual signals. To assist in data analysis, the students must have computer facility and be willing to acquire minimal facility with the Matlab programming language. For students who have taken Bio. 182, there are some projects related to material covered in course.
George Sperling: firstname.lastname@example.org, (949) 824-6879
Michael Stamos, Department of Colon and Rectal Surgery
RESEARCH DESCRIPTION: Description: Students will be exposed to colorectal surgery, minimally-invasive surgery and surgical endoscopy. Your experience will span the spectrum of clinical research. You might begin a project and help create a study based on recent research or assist in writing an IRB (institutional review board) proposal, enrolling patients in ongoing studies, data compilation or writing/presenting your research. Your experience as a research associate will be enhanced by being assigned to faculty and staff as liaisons for each project you work on. Wednesday afternoon research meetings will help to monitor progress as well as assist in furthering your research experience. Opportunities for publication and possibly presentation at local conferences are available. REQUIREMENTS TO PARTICIPATE: -3.25 overall GPA -sophomore standing -Tuesday evening availability (not always necessary) -Attend at least one clinic weekly -one to two year commitment -Four hours/unit/wk -Minimum of 2 units -Ability to work independently as well as in a group setting FACULTY MEANS OF EVALUATION FOR COURSE GRADE: -Work performance -Initiative -Quarterly research summary. OFFICE LOCATION: 33 City Drive South Orange, Ca 92868
Teresa Watters: email@example.com, (714) 456-6262
Craig Stark, Neurbiology and Behavior
RESEARCH DESCRIPTION: Research in my laboratory is concerned with the mechanisms that underlie memory. The central question guiding research in my laboratory is, how is it that we learn and remember information such that our past experiences influence our behavior? Specifically, we use the techniques of functional magnetic resonance imaging (fMRI), traditional experimental psychology, neuropsychological studies of amnesic patients, and studies of age-related memory changes to determine how the neural systems supporting these various types of memory operate and interact. REQUIREMENTS TO PARTICIPATE: Must be highly motivated and interested in the cognitive neuroscience of memory and in research with human participants. COURSE COMPLETION: Open GRADE POINT AVERAGE: 3.3 TIME COMMITMENT PER WEEK: 6+ hours NUMBER OF UNITS REQUIRED: 2+ FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Grade will be based on effort, participation, responsibility, and quality of work. OFFICE LOCATION: Qureshey 213
Craig Stark: firstname.lastname@example.org, (949) 824-4201
Arnold Starr, M.D. Neurology, Anatomy & Neurobiology
Clinically related research using brain electrical recordings. We see patients with impairment of memory, normal aging, and disordered sensory/motor functions. Patients are examined Wednesday afternoons and if suitable will be recruited for laboratory studies using scalp recordings (evoked potentials) to analyzed of brain activities related to their problems. Students can select working in the Clinic or working in the research lab or both, the latter only if they have sufficient time . The patents are only seen in the Clinic on Wednesday afternoon (1-5PM) and their charts are reviewed both before and after the encounter 3 hours). The student will be expected to spend 8 hours related to the Clinic or 8- hours related to the Lab Requirements: Course completion: Physiology E109 & Neurobiology N110, 15 hours per week. Faculty means of evaluation for course grade: work products.
Arnold Starr: email@example.com, (949) 824-4209
Tatsuya Suda, Ph.D. Information and Computer Science
RESEARCH DESCRIPTION: Molecular Communication is a new and interdisciplinary research area that spans the nanotechnology, biotechnology, and communication technology. Molecular communication allows nanomachines to communicate using nano-scale molecules as communication carriers. The molecular communication research group is currently designing two specific instances of molecular communication and investigating the dynamic characteristics through computer simulation and biological lab experiments. Participating undergraduate students will be mainly responsible for computer simulation and literature survey. REQUIREMENTS TO PARTICIPATE: Commitment to the project for at least two quarters. Basic knowledge in two or more of the following areas preferable; biology, chemistry, physics, computer science and engineering. More specific areas of interests are the following (1) calcium signaling; (2) molecular motors; and (3) mathematical modeling and computer simulation of (1) and (2). GRADE POINT AVERAGE: 3.3 TIME COMMITMENT PER WEEK: 10 hours per week NUMBER OF UNITS REQUIRED: 2-5 units OTHER: Financial support available for selected undergraduate researchers willing to work extra hours. For more detail, contact Prof. Tatsuya Suda at firstname.lastname@example.org. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Accomplishment of assignments, willingness to survey related materials, active participation in discussion. OFFICE LOCATION: 3243/3231 /3241 Bren Hall, Donald Bren School of Information and Computer Sciences
Tatsuya Suda: email@example.com, (949) 824-4105
Christine Suetterlin, Developmental and Cell Biology
NAME: Christine Suetterlin DEPARTMENT: Developmental and Cell Biology EMAIL: firstname.lastname@example.org LOCATION OF RESEARCH: 4150 McGaugh Hall TELEPHONE: 824-7140 RESEARCH DESCRIPTION: We study the regulation of the centrosome in mammalian tissue culture cells. This organelle is a small, non-membrane bound structure, which is critical for the organization of microtubules during interphase and mitosis. Abnormalities of the centrosome are found in most human cancers and are thought to cause defects in chromosome segregation and to lead to genetic instability. We are particularly interested in a signaling pathway by which Golgi proteins control the organization and function of this organelle. We also examine how this organelle is assembled and how its protein composition is controlled during the cell cycle. In addition, we are interested in determining how the intracellular bacterium, Chlamydia trachomatis induces abnormalities of the centrosome. This unique interaction of the bacterium with its host cell may provide a mechanism that links this common pathogen to the development of cervical cancer. REQUIREMENTS TO PARTICIPATE: interest and enthusiasm in cell biology and host pathogen interactions highly motivated sophomore and juniors are preferred candidates should be able to commit to at least one year COURSE COMPLETION: complete course list and grades should be sent to email@example.com GRADE POINT AVERAGE: 3.5 TIME COMMITMENT PER WEEK: minimum of 15 hours, preferentially in 3 to 5 hour blocks
Christine Suetterlin: firstname.lastname@example.org, (949) 824-7140
Katumi Sumikawa, Neurobiology & Behavior
We study the role of nicotine receptors in cognitive function. Students will be able to learn more about cell and molecular biology in the neurosciences. They can practice techniques such as in situ hybridization, immunohistochemistry, western blotting, etc. Requirements: 2nd or 3rd year students preferred,Completion of Bio. 93, grade point average of >3.0, >12 hours per week, 4 or 5 units. Faculty Means of evalualtion for course grade: grades will be based on the quality of work.
Katumi Sumikawa: email@example.com, (949) 824-5310
Andrea Tenner, Ph.D. Molecular Biology & Biochemistry
Research area: Innate Immunity. Alzheimer’s Disease. The research program in the Tenner laboratory is multidisciplinary, assessing the interface between the nervous system and the immune system in health and disease. Current research focuses is on certain components of the innate immune system, complement pathway can contribute to the prevention of autoimmunity and induce protective gene expression in neurons, while others play a detrimental role in Alzheimer’s disease, the dominant dementia-causing neurodegenerative disorder of the elderly. Molecular, biochemical, cellular, and behavioral assays are used to characterize disease mechanisms and test therapeutic interventions in human cell systems and animal models. The goal is to develop therapeutic interventions to limit damaging inflammation and autoimmunity or to enhance neuroprotection. Requirements: GPAof 3.4, 12-16 hours per week, 3-4 units, sophomore and juniors are preferred. At least one year commitment to the laboratory. Faculty Means of Evaluation for course grade: Weekly one paragraph reports, performance, 2 page end of the quarter written reports. Supervisor will be a postdoctoral fellow or graduate student. Send informal transcript, area of interest, number of hours committed to research.
Andrea Tenner: firstname.lastname@example.org, (949) 824-3268
Krishnansu Tewari, M.D., FACOG, FACS Obstetrics & Gynecology
Division of Gynecologic Oncology. RESEARCH DESCRIPTION: Retrospective chart reviews designed to answer important clinical questions regarding the epidemiology, clinical evaluation & treatment, and/or ultimately, outcome of patients diagnosed with gynecologic malignancies (eg., cervical cancer, endometrial cancer, ovarian cancer, vulvar cancer, vaginal cancer). The research projects require the preparation of an application to the UC Irvine Institutional Review Board (IRB), a literature review, and review of medical records. All clinical material must be maintained in the highest confidentiality and only those students listed on the approved UCI IRB application may participate in a given study. In addition to the above listed responsibilities, the students will be trained in the creation of an xL file for data analysis. Students are encouraged to participate in the statistical analysis of the data, preparation of abstracts/posters/manuscripts. It is anticipated that each project shall result in the publication of a manuscript in a peer-reviewed scientific journal. Students are also encouraged to present their research at their Undergraduate Research Symposium. REQUIREMENTS TO PARTICIPATE: Bio 194S Safety & Ethics Course Prior To Enrollment. GRADE POINT AVERAGE: > 3.5 TIME COMMITMENT PER WEEK: At least 6 hours per week FACULTY MEANS OF EVALUATION FOR COURSE GRADE: 1. Students will be assigned to work with a Resident in Obstetrics & Gynecology or a Fellow in Gynecologic Oncology. The Resident or Fellow will provide me with a written description of the level of the students’ participation, conduct, and efficiency in the study. 2. The student will also be required to make a 15 minute presentation of their research to me using a powerpoint file. OFFICE LOCATION: 101 The City Drive South Building 56, Room 275 University of California, Irvine – Medical Center Orange, CA 92868
Krishnansu Tewari: email@example.com, (949) 813-1517 cellphone
Leslie Thompson, Neurobiology and Behavior
RESEARCH DESCRIPTION: Dr. Thompson has the distinction of being on the team that identified and continues to characterize the huntingtin gene. She is a pioneer in the field of neurodegeneration and continues to be innovative in her new reach into the stem cell field. Huntington’s Disease (HD) is an autosomal dominant neurodegenerative disease characterized by specific regions of neuronal dysfunction and loss, most notably of neurons in the striatum and cortex. There is currently no effective treatment or cure for this devastating disorder. The primary cause of HD is the expansion of a CAG triplet repeat encoding a polyglutamine (polyQ) tract within the amino terminal portion of a predominantly extranuclear protein, Huntingtin (Htt). Work from our lab and others suggest that this mutation disrupts many cellular processes, including transcriptional regulation, vesicular trafficking, mitochondrial function, degradation pathways, protein modification, protein folding and processing pathways. Protein aggregates and inclusions in affected brain regions, presumably the consequence of abnormal protein folding and/or proteolytic cleavage and degradation of the polyQ repeat-containing protein, are common hallmarks in all polyQ disorders. Cleavage of full-length Htt appears to be an important step in pathogenesis, as does subsequent nuclear accumulation of mutant Htt. Understanding the molecular basis of neuronal dysfunction and death as a consequence of CAG repeat expansion, which appears to confer a dominant toxicity, is critical to development of effective therapies. The molecular and cellular basis of HD pathogenesis is studied using multidisciplinary systems including in vitro, cell culture, Drosophila and mouse models. In collaboration with Dr. J. Lawrence Marsh at UCI, a Drosophila model to study triplet repeat pathogenesis is effective at modeling disease pathogenesis and is part of a long standing collaboration between the two labs. Approaches to investigate neuronal dysfunction include targeted studies of Htt oligomerization and its role in neurotoxicity, transcriptional dysregulation in the context of chromatin remodeling and epigenetics, protein modifications of the mutant protein that influences its clearance and cellular localization, and altered signal transduction in HD. Together with Dr. Joan Steffan at UCI, we are focusing upon the role of post-translational modifications of the Htt protein in cellular localization, transcription and protein clearance. Genetic and pharmacologic approaches to develop therapeutics are active areas of research using each of these systems. However, since molecular commonalities such as defective signal transduction, aggregation and altered transcription have emerged for diseases that involve aberrant protein folding such as Alzheimer’s disease, these efforts have applications to a wide range of neurodegenerative diseases. Aberrant expression of wild-type or hyperactive fibroblast growth factor receptor 3 (FGFR3), a member of a family of receptor tyrosine kinases that function in a broad spectrum of cellular processes, is associated with a number of human cancers including hematologic cancers such as multiple myeloma (MM). The pathogenesis of FGFR3-mediated MM is the focus of fairly recent work in the lab, Dysregulation of FGFR3 appears to be oncogenic, since aberrant growth and survival of tumor cells is related to increased activation of FGFR3 and downstream signaling pathways. Concurrent with disease progression, a subset of these develop activating mutations in FGFR3 which appear to confer an adverse prognosis; these mutations are identical to those in TD. We are using both unbiased and hypothesis driven approaches to understand the mechanisms involved in FGFR3-associated pathophysiology and to identify therapeutic approaches. Specifically, novel protein interactors and signaling pathways for FGFR3 identified through yeast two-hybrid screening are under investigation. REQUIREMENTS TO PARTICIPATE: Major in one of the life sciences. COURSE COMPLETION: completion of Bio 194S, completion of 1 year of general chemistry, completion of 2 biology courses, must have completed 1 year of studies at UC Irvine. Organic chemistry preferred. GRADE POINT AVERAGE: 3.3 TIME COMMITMENT PER WEEK: 10-16 hrs NUMBER OF UNITS REQUIRED: 3 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: graded. LOCATION OF RESEARCH: Biological Sciences 3.
Andrew Tran: firstname.lastname@example.org
Kevin Thornton, Ph.D. Ecology and Evolutionary Biology
The Thornton lab works on a variety of topics in population genetics, primarily using Drosophila melanogaster as a model system. For more detail, please see http://molpopgen.org/thorntonlab/index.html.
Kevin Thornton: email@example.com, (949) 824-0614
Jeremiah Tilles, M.D. Infectious Diseases
We are researching for students who are interested in virology. We have two research projects – 1) to investigate the mechanism of persistent virus infections and their role in neurological diseases. 2) to investigate the antibody response in HIV infection and their use as a part of a vaccine. The students will be trained in molecular biology and immunology. Requirement: We require that the students are staying in the lab for at least one year or longer and spend at least 12 hours per week at the lab.
Martina Berger: firstname.lastname@example.org, (714) 456-5161
Jerome Tobis, PMR
Clinical research on 1) pain and guided imagery 2) spasticity in developmentally disabled Requirements: UCI undergaduate who will spend 1-2 years with me and my colleagues. 2 units. 4 hrs/wk. Office: UCIMC RM 17 Bldg 53.
Jerome Tobis: email@example.com, (714) 456-5626
Francesco Tombola, Ph.D. Physiology and Biophysics
RESEARCH DESCRIPTION: The molecular devices responsible for the generation and propagation of electrical signals in our brain and muscles are ion channels. These are pore-forming proteins which allow the flow of ions across biological membranes down their electrochemical gradient. Malfunction of such proteins is the cause of several neurological and cardiovascular diseases. We study how ion channels work at the molecular level using electrophysiological methods (e.g., patch-clamp and two-electrode voltage-clamp), combined with fluorescence microscopy and molecular biology. Students will subclone ion channel proteins and will introduce single-point mutations using recombinant DNA techniques. They will then participate in the electrophysiological recordings and/or in the fluorescence measurements from the mutated ion channels expressed in cultured cells. REQUIREMENTS TO PARTICIPATE: The typical student enrolled in this course majors in Biological Sciences, Biomedical Engineering, or related subjects. COURSE COMPLETION: BIO-94, CHEM-1C&1LC, MATH-2A GRADE POINT AVERAGE: 3.5 or higher TIME COMMITMENT PER WEEK: 4 hours per week or higher (in at least 2-hour blocks) NUMBER OF UNITS REQUIRED: 1 Unit per quarter or higher OTHER: FACULTY MEANS OF EVALUATION FOR COURSE GRADE: The grade will be mainly based on the quality of the experiments performed, as well as the accuracy in lab notebook keeping. The student is also required to write a 3-4 page report on the literature related to his/her project, and to give a short lab-meeting presentation about his/her work at the end of the quarter. LOCATION OF RESEARCH: D380 Medical Sciences I.
Francesco Tombola: firstname.lastname@example.org, (949) 824-9137
Kathleen Treseder, Ph.D. Ecology
Four Bio. 199 positions available in both summer and fall. Students would conduct projects studying how global change affects soil microbes or plants. Requirement: must have a block of time 3 hours or longer during the week in order to conduct laboratory work.
Kathleen Treseder: email@example.com, (949) 824-7634
Theo G.M. van Erp, Ph.D. Department of Psychiatry and Human Behavior
RESEARCH DESCRIPTION: Neuropsychiatric Imaging Research Current research involves numerous structural and functional MRI and PET imaging studies. Students can be involved in experiment programming, data collection, data organization, data analysis and visualization, literature review, interpretation of results, and weekly team meetings to discuss projects. Looking for students interested in learning more about brain imaging, brain function and dysfunction. REQUIREMENTS TO PARTICIPATE: minimum 1 year commitment GRADE POINT AVERAGE: > GPA 3.0 TIME COMMITMENT PER WEEK: minimum 6 hours NUMBER OF UNITS REQUIRED: 2 FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of work performed and participation. LOCATION OF RESEARCH: 5251 California Avenue, Suite 240C, Irvine, CA 92617.
Theo G.M. van Erp: firstname.lastname@example.org, (949) 824-3331
Charles Vega, M.D. Family Medicine
RESEARCH DESCRIPTION: The Health Education and Language for the Latino community is a longitudinal program to improve healthcare for Latinos by strengthening providers’ skills in language and culture. Part of the curriculum involves Spanish coaching for Family Medicine residents with some Spanish skills who are not yet fully fluent. We seek Spanish coaches to improve our resident physicians’ communication skills during direct patient care. REQUIREMENTS TO PARTICIPATE: Fluent Spanish. COURSE COMPLETION: None. GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: 4 hours. NUMBER OF UNITS REQUIRED: 1 unit. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Your participation and enthusiasm to teach residents and patients. You may also be given specific assignments, such as assisting patients to complete satisfaction surveys. LOCATION OF RESEARCH: UCI Family Health Center – Santa Ana.
Charles Vega: email@example.com, (714) 456-6502
Pathik Wadhwa, Ph.D. Psychiatry, OB/GYN
Several research studies involving the role of biological and behavioral processes in human pregnancy on fetal/infant development and health (behavioral perinatology). Emphasis on the role of maternal stress and social support, maternal-placental-fetal endocrinology, immunology and genetics, fetal neurodevelopment, and biological and psychosocial markers in infancy of disease risk. Require highly motivated students with an interest in medicine, psychology, basic biology, or epidemiology and public health, who are willing to work 10-12 hours/week for 3 consecutive quarters. Training will be provided.
Everlyne Gomez, MSc, CCRP: firstname.lastname@example.org, (714) 940-1924
Craig Walsh, MB&B
Our laboratory investigates the link between apoptotic/cell death signaling and activation of lymphocytes in the immune system. This link is essential for immunological homeostasis and for the prevention of autoimmune diseases. We are also broadly interested in understanding how cell death signals are propagated. We utilize a number of biochemical, genetic and molecular techniques to address these issues. Requires 1 year commitment. Completion of Bio 99; Bio 121 if possible. GPA 3.0 or better. 10 hrs/wk. 3-5 units. Faculty means of evaluation for course grade: Effort and time put into project; results; end of quarter report.
Craig Walsh: email@example.com, (949) 824-8487
Ping Wang, M.D. Medicine
RESEARCH DESCRIPTION: Hormone actions and diabetic complications. Stem cell research. Dr. Wang’s research during the last two years have provided important insights into how IGF I regulates cardiac muscle gene expression, myocardial structure, and cardiac function. Dr. Wang is a leading authority in the area of IGF-1 actions in the heart. His laboratory is now studying how heat shock proteins modulate signaling pathways of IGF-1. In addition to IGF-1 and insulin, Dr. Wang has been searching for novel hormone/factors that may be used to treat animal models of heart failure. Several ongoing projects in Dr. Wang’s laboratory will continue to explore new frontiers in cardiovascular hormone actions. In addition to these projects, Dr. Wang is also a member of an international team studying the genetics of Type 2 diabetes.Dr. Wang’s research during the last two years have provided important insights into how IGF I regulates cardiac muscle gene expression, myocardial structure, and cardiac function. Dr. Wang is a leading authority in the area of IGF-1 actions in the heart. His laboratory is now studying how heat shock proteins modulate signaling pathways of IGF-1. In addition to IGF-1 and insulin, Dr. Wang has been searching for novel hormone/factors that may be used to treat animal models of heart failure. Several ongoing projects in Dr. Wang’s laboratory will continue to explore new frontiers in cardiovascular hormone actions. In addition to these projects, Dr. Wang is also a member of an international team studying the genetics of Type 2 diabetes. GRADE POINT AVERAGE: 3.5 or above. TIME COMMITMENT PER WEEK: 15 hours or more. LOCATION OF RESEARCH: Gross Hall.
Ping Wang: firstname.lastname@example.org, (949) 824-6887
Rahul Warrior, Ph.D. Dev. & Cell
Research involves Drosophila genetics and molecular biology and will require a minimum time commitment of 12 hours per week. Preference for motivated sophomores and juniors with a minimum 3.0 GPA in Bio. courses.
Rahul Warrior: email@example.com, (949) 824-2597
Marian L. Waterman, Microbiology and Molecular Genetics
RESEARCH DESCRIPTION: Cancer, Stem Cells, Wnt Signaling REQUIREMENTS TO PARTICIPATE: Biology Major GRADE POINT AVERAGE: 3.5 minimum TIME COMMITMENT PER WEEK: 10-12 hours LOCATION OF RESEARCH: Sprague Hall, Rm 240
Marian L. Waterman: firstname.lastname@example.org, (949) 824-2885
Steven L. Wechsler, Ph.D. Ophthalmology
Virus Research. Herpes simplex virus. My lab is interested in understanding the molecular mechanisms of herpes simplex virus type 1 (HSV-1) latency and pathogenesis. Following ocular infection, HSV 1 establishes life long latency in sensory neurons of the trigeminal ganglia. Sporadic spontaneous viral reactivations produce shedding of virus in tears, spread of virus to other individuals, and recurrent ocular disease. Recurrent ocular herpes infection is a major cause of viral induced blindness. Elucidation of the underlying molecular mechanisms behind the HSV 1 latency-reactivation cycle and the immunopathological and molecular mechanisms leading to corneal scarring, should lead to development of means for reducing the incidence of HSV-1 induced blindness. Projects include: 1) molecular biology of how LAT, the only one of over 80 viral genes abundantly expressed during latency, enhances the viral reactivation phenotype via its anti-apoptosis activity; 2) determining if LAT expresses a functional protein or whether it blocks apoptosis via a direct RNA activity; 3) determining if LAT enhances the reactivation phenotype by functioning at the time of latency establishment, reactivation, or a combination of both; and 4) in vivo and ex vivo confocal microscopy directed at the immunopathological, cellular, and molecular mechanism(s) involved in recurrent HSV 1 induced corneal scarring (herpetic stromal keratitis). Techniques that will be learned and used include DNA cloning, sequencing, Southern and Northern blots, RT-PCR, qRT-PCR, RNA isolation, laser microdissection, cell culture, transfection, immunofluorescent microscopy, Western blotting, construction of viral mutants, and confocal microscopy. REQUIRED BACKGROUND OF STUDENT: General biology. Microbiology, Biochemistry, Genetics, helpful. Three positions available. MINIMUM HOURS PER WEEK REQUIRED:10. One year commitment required. LOCATION OF RESEARCH: Hewitt Hall, Building 843, 2nd Floor.
Steven Wechsler: email@example.com, (949) 824-9490
Norman Weinberger, Ph.D. Neurobiology
Research concerns how auditory information is learned and remembered in the brain of rats. Use of behavioral, pharmacological, neurophysiological and anatomical techniques. Up to 30 hours per week during summer, 10-15 hours per week during a two year period.
Norman Weinberger: firstname.lastname@example.org, (949) 824-5512
Arthur Weis, Ph.D. Ecology
We are investigating the consequences of assortative mating by flowering time in plants. The idea is simple-early bloomers will exchange pollen with other early bloomers and late will exchange with late. However, there are several potentially important consequences from this form of non-random mating, including faster evolution for plant developmental rates, higher speciation rates, elevated inbreeding levels, and potentially slower evolution of stress resistance mechanisms. Most importantly is the possibility of accelerated adaptation to some components of global change. Greenhouse and filed experiments with the plant Brassica rapa, the wild mustard, are under way. Students entering the lab spend 1-2 quarters as assistants on larger projects under the direction of myself, a post-doc or grad student. Continuing students purse their own independent project. Completion of Bio E106 required, 3.0 GPA and potential career interests in research or environmental protection.
Arthur Weis: email@example.com, (949) 824-2241
Gregory Weiss, Ph.D. Molecular Biology and Biochemistry
The Weiss Laboratory pursues both chemical and biological aspects of chemical biology. Using chemistry to advance a molecular understanding of biology, the lab dissects key events in biology with exceptionally diverse combinatorial libraries as atomic-scale scalpels. Our libraries, collections of different molecules, include virus-displayed proteins and chemically or enzymatically synthesized small molecules. Libraries displayed on the surfaces of viruses also offer essentially universal molecular recognition for chemical sensors, illustrating how biology can advance chemistry. Undergraduates play key roles in this research, including conducting experiments both in teams and individually and co-authoring publications. Requirements: Strong interest in graduate study, competitive GPA and grades in key chemistry/biology courses, 15+ hours per week commitment, and >1.5 years remaining of study at UCI.
Gregory Weiss: firstname.lastname@example.org, (949) 824-5566
John Weiss, M.D./Ph.D. Anatomy & Neurobiology
In vitro and in vivo studies of mechanisms of neurodegeneration and strategies for protecting neurons.Specific current areas of focus include, Roles of calcium and zinc ions in excitotoxic injury: routes of entry, intracellular regulation, and intracellular effects; Ca permeable AMPA/kainate channels:their expression, function and roles in neural signaling and in selective neurodgeneration; Mitochondrial dysfunction and free radical generation in neuronal injury; Cellular mechanisms of nerve cell loss in Alzheimer’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis; Trophic factors and interneuronal signaling in neuronal survival and growth; in vitro models. Required: one year of chemistry, courses in general biology and neuroscience. Strongly recommended, Biochemistry course. Selection criteria: ability to work independently, neat and thorough work habits, GPA of 3.3 or above.
Allan Acab: email@example.com, (949) 824-6774
Stephen Weller, Ph.D. Ecology
Flowering plants have a great diversity of breeding systems. Some species are hermaphroditic, others have females and hermaphrodites, and still others have only males and females. Our lab is interested in factors that promote these different breeding systems and the genetic potential of plants to evolve these different breeding systems. Understanding these processes provide information important in conservation, agriculture, and basic sciences. Undergraduates are directly involved in research and work closely with faculty and students in the greenhouse and laboratory on the rare Hawaiian genus Schiedea and on the genus Oxalis. Interest in ecology, conservation and/or evolution required; must have at least 2 years remaining at UCI; prefer GPA of 3.0 or higher.
Stephen Weller: firstname.lastname@example.org, (949) 824-6581
Sharon Wigal, Ph.D. Pediatrics
Students who can commit to 9 months to a year of involvement with research with ADHD children and adults. Have an opportunity to learn about research protocols and implementation of clinical trials of medications and other treatments. Students will be trained in reading and implementing study protocols, interview skills, achievement testing, data collection techniques and data entry. Good experience for students interested in careers in medicine, psychology or neuropsychology.
Sharon Wigal: email@example.com, (949) 824-1833
Timothy Wigal, M.D. Pediatrics
Students who can commit to 9 months to a year of involvement with research with ADHD children and adults. Have an opportunity to learn about research protocols and implementation of clinical trials of medications and other treatments. Students will be trained in reading and implementing study protocols, interview skills, achievement testing, data collection techniques and data entry. Good experience for students interested in careers in medicine, psychology or neuropsychology.
Tim Wigal: firstname.lastname@example.org, (949) 824-1812
Petra Wilder-Smith, Beckman Laser Institute/Surgery
Laser use in dentistry/oral medicine for non-invasive diagnostics, therapeutics. Requirements: 2 years; pre-dental. Completed core classes for bio; intro chemistry. 3.0 GPA minimum. Min 8 hours available in 2-4 hr blocks. 2 units. Good self-motivation, good team worker, responsible, strong desire to learn to perform independent research. Faculty means of evaluation for course grade: research, publication, award performance.
Petra Wilder-Smith: email@example.com, (949) 824-4713
Deborah A. Wing, M.D. Obstetrics and Gynecology
RESEARCH DESCRIPTION: We have many exciting opportunities to participate in our research program within the division of maternal fetal medicine. We have several NIH/NICHD funded research protocols, industry sponsored trials as well as investigator initiated studies. Students working on these projects will have the opportunity assist with implementation of study protocols, medical record abstraction, data collection, data entry, and the opportunity exists for laboratory processing of blood samples (i.e. centrifugation, aliqouting, to placement in long term storage). We are looking for highly motivated students with an interest in medicine, obstetrics and gynecology, maternal fetal medicine and/or pediatrics, who are willing to work 10-15 hours/week for a minimum of 3 quarters. Students should have access to transportation to and from the Medical Center. REQUIREMENTS TO PARTICIPATE: • Transportation to and from the research sites • Minimum three quarters commitment • Reliable • An interest in working in medicine, Obstetrics and Gynecology, Maternal Fetal Medicine and/or Pediatrics. • Computer skills: MS Word and Excel. Use of email. COURSE COMPLETION: N/A GRADE POINT AVERAGE:3.0 TIME COMMITMENT PER WEEK: 10-15 hours per week NUMBER OF UNITS REQUIRED: 3 units minimum per quarter. OTHER: Foreign language speaking ability desired (Spanish, Vietnamese, Chinese, Korean, etc.) desired, but not required. FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Hours completed and quality of work completed. Deborah A. Wing, MD through the Maternal Fetal Medicine Research Nurse Administrator, Pamela J. Rumney, RNC, CCRC: Assistant: TBD:, CONTACT PERSON: Marcus Umali EMAIL: Mumali@uci.edu TELEPHONE: 714 456-2217. LOCATION OF RESEARCH: UCI Medical Center locations: 200 Manchester Ave., Ste. 130, Orange; Fountain Valley Regional Medical Center 11190 Warner Ave., Ste. 407, Fountain Valley; Long Beach Memorial Medical Center Perinatal Offices at 2888 Long Beach Blvd. Ste. 400, Long Beach.
Marcus Umali: firstname.lastname@example.org, (714) 456-2217
Dominik Wodarz, Ph.D. Ecology & Evolutionary Biology
Mathematical and computational biology, applied to biomedical problems. We use mathematical models and computer simulations in order to understand the interactions between the immune system and viral infections. In particular, we study HIV infection, how the virus escapes immune responses, and what causes disease progression. Computational skills are required.
Dominik Wodarz: email@example.com, (949) 824-2531
Brian J.F. Wong, Otolaryngology- Head & Neck Surgery, Biomedical Engineering,
The laboratory is headed by Dr. Brian Wong, a professor of Otolayngology-Head and Neck surgery and biomedical engineering. Having a fellowship in Facial Plastic Surgery, his medical practice is focused on aesthetic, corrective, and reconstructive facial surgery.——– Project #1: The majority of research conducted in his laboratory deals with minimally invasive techniques to reshape, alter, and regenerate soft tissues. Currently, we have several projects that aim to explore the use of lasers and electromagnetic energy to reshape cartilage. This innovative research aims to provide a non-surgical method to reshape the ear and parts of the nose and therefore decrease the cost and risks associated with the operating room. In addition, there are several projects that are currently exploring the use of lasers in the correction of disorders of joints and tendons. We encourage students to formulate their own project, carry out the experimentation, and submit a manuscript to a peer reviewed journal. However, this requires dedication, and a long-term commitment. Campuswide Honors Program students are preferred, but exceptions are made. Contact Allen Foulad at firstname.lastname@example.org for inquiries. ——– Project #2: Our research group focuses on studying innovative methods to determine facial attractiveness. Currently, we have several projects that aim to explore the trends in lip size and effects of cosmetic lip enhancers. Recently published works include evolving facial attractive faces using morphing technology, determining the ideal lip dimensions for an attractive face, and determining the most attractive eyebrow arch. This innovative research aims to provide insight on the definitions of facial beauty while exploring the dynamics and changes over time. Students are encouraged to create new projects, work through experimentation, and publish manuscripts through peer reviewed journals. This research presents as a great opportunity to work with and learn from a medical doctor. REQUIREMENTS TO PARTICIPATE: 3 quarter commitment, student must have knowledge of Microsoft windows; knowledge of Photoshop is a plus GRADE POINT AVERAGE: 3.0 + TIME COMMITMENT PER WEEK: Weekly meetings NUMBER OF UNITS REQUIRED: 4 unit commitment CONTACT PERSON: Lauren Law: email@example.com
Allen Foulad: firstname.lastname@example.org, (949) 824-4770
Nathan D. Wong, Ph.D. Cardiology, Department of Medicine
RESEARCH DESCRIPTION: The Heart Disease Prevention Program conducts statistical/epidemiologic research focused on cardiovascular risk factors and screening for early, subclinical disease utilizing state, national and other large databases, including well-known prospective epidemiologic studies of cardiovascular disease. Key areas of specific interest include metabolic syndrome/diabetes, hypertension, dyslipidemia, pulmonary disease, and subclinical atherosclerosis. Participating students work with one of several faculty members and senior students working in these areas and participate actively in statistical analysis and scientific manuscript writing, with opportunity to co-author manuscripts for submission to medical journals. REQUIREMENTS TO PARTICIPATE: A strong written English and quantitative background is needed, with a minimum of one (preferably two) quarters each of statistics/biostatistics and advanced composition/writing courses (however, one quarter of each is required for entry and the additional quarter may be taken concurrently in the first two quarters of the research). A major in biology, biochemistry, statistics/mathematics, or engineering/biomedical engineering is useful but not required. Strong communication skills and prior research is preferred but not required. COURSE COMPLETION: See above GRADE POINT AVERAGE: 3.5 or higher TIME COMMITMENT PER WEEK: 9-12 hours minimum, including summers, two years participation required, plus weekly group meetings/lectures (usually Wednesday afternoons). NUMBER OF UNITS REQUIRED: 2-3 per quarter FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Performance of and timely completion of assigned project tasks are the main criteria for evaluation; a written examination may also be given based on training lectures. LOCATION OF RESEARCH: Sprague Hall, UCI Campus TELEPHONE: Email requests only. Interested students, please submit resume for consideration.
Nathan Wong: email@example.com
Marcelo Wood, Ph.D. Neurobiology & Behavior
We investigate the molecular mechanisms of memory storage using genetically modified mice. Transcriptional activation is thought to be a key process in long-lasting forms of memory. This activation is directed by transcription factors and their coactivators, which regulate gene activation via chromatin remodeling activity or histone covalent modification activity as well as mediating interactions with basal transcription machinery components. One type of histone modification associated with transcriptional activation is acetylation, which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) that add or remove acetyl groups from histones, respectively. The main goal of our research is to understand how these chromatin remodeling complexes regulate gene expression required for memory processes. The research is a combined approach of molecular, biochemical, pharmacological, and behavioral analysis. REQUIREMENTS TO PARTICIPATE: Completion of Bio N110, minimum GPA of 3.0. Ideal student will be highly motivated, work 10-15 hours/week, and make a minimum 1 year commitment. COURSE COMPLETION: Bio 110 GRADE POINT AVERAGE: 3.0 TIME COMMITMENT PER WEEK: 10-15 hours NUMBER OF UNITS REQUIRED: 3-4 OTHER: minimum 1 year commitment FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Quality of research performed and understanding of topic.
Marcelo Wood: firstname.lastname@example.org, (949) 824-2259
Sing-Yung Wu, M.D., Ph.D. Radiological Sciences and Medicine
RESEARCH DESCRIPTION: Title: Peripheral Thyroid Hormone Metabolism Thyroid hormone (TH) is vitally important to the normal fetal brain development. The peripheral TH metabolism in perinatal period is the key regulating step to optimize the hormonal supply to the fetus. The emphasis in VA Thyroid Lab is the studying maternal/fetal exchange in TH metabolites, including sulfated iodothyronines, in mammalian species. REQUIREMENTS TO PARTICIPATE: Pre-med major after freshman COURSE COMPLETION: General Chemistry, Analytical Chemistry, Biology and one semester of Organic Chemistry GRADE POINT AVERAGE: > 3.6 TIME COMMITMENT PER WEEK: Two half days NUMBER OF UNITS REQUIRED: 2 – 5 OTHER: None FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Regular completion of committed time, quality of bench-top research and enthusiasm. LOCATION OF RESEARCH: Long Beach VA Medical Center
Sing-Yung Wu: email@example.com, (562) 826-5808
Xiangmin Xu, Ph.D. Anatomy and Neurobiology
RESEARCH DESCRIPTION: The overall interest of Dr. Xiangmin Xu’s laboratory is to understand organization and function of cortical circuits, with a particular emphasis on identified neuronal types and microcircuits. Currently we focus on examining local connectivity and in vivo physiology of inhibitory neurons in the cerebral cortex, by using combined approaches such as electrophysiology, laser scanning photostimulation, optical imaging and transgenic mice. Participating students will work with graduate students and postdoctoral scholars, and help with neuroscience research. They will gain hands-on experience, and learn how to collect data, analyze data. They will also learn how to read literature and write scientific papers, and present their work at lab meetings and other occasions. REQUIREMENTS TO PARTICIPATE: Students should be organized, motivated and detail-oriented. He/she should be able to work relatively independently, and have a good teamwork attitude. COURSE COMPLETION: See Bio Sci 199 Standards & Policies GRADE POINT AVERAGE: 3.0 or above TIME COMMITMENT PER WEEK: 15 hours FACULTY MEANS OF EVALUATION FOR COURSE GRADE: For Bio Sci 199 the grade of A+ will be awarded only when the research is beyond excellent and includes such achievements as publications and research presentations or awards at scientific meetings. A – Excellent (4.0 grade points awarded per unit) B – Good (3.0 grade points per unit) C – Average (2.0 grade points per unit). Plus and minus suffixes may be attached to the grades A, B, C. LOCATION OF RESEARCH: 348 Med Surge II
Xiangmin Xu: firstname.lastname@example.org, (949) 824-0040
Kyoko Yokomori, Ph.D. Biological Chemistry
Good chemistry and biology background. Biochemistry preferred. Gpa of 3.3, motivation, commitment, good learning attitude, interview required. Studying mechanism of chromosome dynamics and its role in genome functions, local and global structural changes of chromosomes play critical roles in regulation of various genome functions, including mitotic chromosome organization, RNA transcription, DNA replication, DNA recombination and repair.
Kyoko Yokomori: email@example.com, (949) 824-8215
Fan Gang Zeng, Ph.D. Head & Neck Surgery
Conduct hearing and speech experiments in normal-hearing and cochlear-implant listeners. Programming experience will be helpful but not required. 10-15 hours per week during academic year.
Fan Zeng: firstname.lastname@example.org, (949) 824-1539
Qun-Yong Zhou, Ph.D. Pharmacology
Conduct biochemical, cellular and behavioral pharmacology experiments. Previous biochemistry lab will be helpful but not required. 10-15 hours per week during academic year.
Qun-Yong Zhou: email@example.com, (949) 824-2232
Yi-Hong Zhou, Neurological Surgery
RESEARCH DESCRIPTION: Tumor suppression pathways in glioma: Gliomas are glia neoplasm in brain. One of the challenges in the treatment of glioma is the frequency of recurrence, resulting from residual highly invasive tumor cells after tumor removal. Glioblastoma multiforme (GBM) is the most common glioma. At present, there are no effective therapies for GBM, and the prognosis is extremely poor. Identifying molecules and the regulatory pathways that are responsive for the malignant nature of glioma may provide insights into how to develop new, more effective treatments for these tumors. A gene encoding a transcription factor PAX6 was suggested by our previous studies to function as a gatekeeper from further pathological processing in GBM. This project focuses on characterization of PAX6-mediated tumor suppression pathways that are responsible for the pathological hallmarks of GBM (microvascular amplification, central necrosis, and tumor invasion) and resistance to clinical therapy, and its therapeutic potential. Characterization of genetics and evolution of brain tumor stem cells: GBM is characterized by a histologically heterogeneous cell population leading to the name “multiforme”. The heterogeneity that characterizes these cancers suggests that powerful selective pressures on genetic changes in critical target cells drive a rapid evolution of GBM onset and progression. Our study is focused on the genetic changes within the tumor stem cells and microenvironmental subpopulations and the relative contribution/importance of each in the progression of GBM. REQUIREMENTS TO PARTICIPATE: Previous biochemistry/molecular biology lab will be helpful but not required. GRADE POINT AVERAGE: 3.5 TIME COMMITMENT PER WEEK: 10-15 hours per week during academic year. NUMBER OF UNITS REQUIRED: 3-4 Units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Participation in research activity, lab meeting, and participation in Excellence in Research Symposium / Undergraduate Research Opportunities Symposium / Co-author on research article from the lab. OFFICE LOCATION: MedSci C214
Yi-Hong Zhou: firstname.lastname@example.org, (949) 824-5767
Xiaolin Zi, Urology and Pharmaceutical Sciences
RESEARCH DESCRIPTION: Natural Products, Molecular Targets, and Cancer Prevention and Therapy. The Urological Oncology Lab at UC Irvine Medical Center focuses on identification and characterization of novel phytochemicals, their derivatives for prevention and treatment of prostate and bladder cancers, and the study of the mechanisms of their actions. Current projects include (1) The role of secreted Wnt inhibitors in prostate cancer tumorigenesis and progression; (2) Lycopene and docetaxel in treatment of hormonal-refractory prostate cancer: an IGF-I receptor targeting approach; (3) Novel kava chalcones, Flavokawains, in chemoprevention of prostate and bladder cancers. (4) Targeting androgen receptor signaling for treatment of hormonal-refractory prostate cancer. These research projects are currently funded by the National Cancer Institute and American Institute for Cancer Research. Students will be assigned to a small project by Dr. Xiaolin Zi, depending on the commitment and enthusiasm of the student to the project, and work in collaboration with several post-doctoral fellows in the laboratory. The students will be trained with experimental techniques, including cell culturing, DNA and RNA isolation, cDNA synthesis, PCR, immunocytochemistry, immunofluorescence, Western blotting, flow cytometry, and ELISAs. REQUIREMENTS TO PARTICIPATE: Complete clinical package (Packet B) to work at UCIMC laboratory. COURSE COMPLETION: Completion of Bio. 194 Safety & Ethics is required and a basic course in biochemistry/chemistry would be preferable. GRADE POINT AVERAGE: GPA of 3.5 or better TIME COMMITMENT PER WEEK: Would prefer a minimum of 15-20 hours/week for at least a year. NUMBER OF UNITS REQUIRED: 3 to 4 units FACULTY MEANS OF EVALUATION FOR COURSE GRADE: Participation, Quality of Work, and Development of Independence. LOCATION OF RESEARCH: UC Irvine Medical Center, Bldg. 55, Rm. 360
Xiaolin Zi: email@example.com firstname.lastname@example.org, (714) 456-8316