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X-WR-CALNAME:Charlie Dunlop School of Biological Sciences
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X-WR-CALDESC:Events for Charlie Dunlop School of Biological Sciences
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260312T110000
DTEND;TZID=America/Los_Angeles:20260312T120000
DTSTAMP:20260115T041515Z
CREATED:20260115T041511Z
LAST-MODIFIED:20260115T041515Z
UID:54700-1773313200-1773316800@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Jeff Farrell
DESCRIPTION:
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-jeff-farrell-2/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2026/01/dcb-series-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260305T110000
DTEND;TZID=America/Los_Angeles:20260305T120000
DTSTAMP:20260115T174954Z
CREATED:20260115T174949Z
LAST-MODIFIED:20260115T174954Z
UID:54703-1772708400-1772712000@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Bryan Sun
DESCRIPTION:
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-bryan-sun/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2026/01/dcb-series-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260226T110000
DTEND;TZID=America/Los_Angeles:20260226T120000
DTSTAMP:20260102T215523Z
CREATED:20260102T215519Z
LAST-MODIFIED:20260102T215523Z
UID:54518-1772103600-1772107200@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Ashleigh Schaffer
DESCRIPTION:
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-ashleigh-schaffer/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2026/01/dcb-series-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260219T110000
DTEND;TZID=America/Los_Angeles:20260219T120000
DTSTAMP:20260102T215434Z
CREATED:20260102T215431Z
LAST-MODIFIED:20260102T215434Z
UID:54515-1771498800-1771502400@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Vini Duarte
DESCRIPTION:
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-dr-vini-duarte/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2026/01/dcb-series-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260212T110000
DTEND;TZID=America/Los_Angeles:20260212T120000
DTSTAMP:20260102T215352Z
CREATED:20260102T215349Z
LAST-MODIFIED:20260102T215352Z
UID:54513-1770894000-1770897600@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Ryo Sanabria
DESCRIPTION:
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-ryo-sanabria/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2026/01/dcb-series-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260205T110000
DTEND;TZID=America/Los_Angeles:20260205T120000
DTSTAMP:20260102T215311Z
CREATED:20260102T215308Z
LAST-MODIFIED:20260102T215311Z
UID:54510-1770289200-1770292800@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Angelike Stathopoulos
DESCRIPTION:
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-angelike-stathopoulos/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2026/01/dcb-series-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260129T110000
DTEND;TZID=America/Los_Angeles:20260129T120000
DTSTAMP:20260102T215139Z
CREATED:20260102T215136Z
LAST-MODIFIED:20260102T215139Z
UID:54488-1769684400-1769688000@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Ariel Bazzini
DESCRIPTION:
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-dr-ariel-bazzini/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2026/01/dcb-series-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260122T110000
DTEND;TZID=America/Los_Angeles:20260122T120000
DTSTAMP:20260102T215052Z
CREATED:20260102T215048Z
LAST-MODIFIED:20260102T215052Z
UID:54485-1769079600-1769083200@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Richard Chang
DESCRIPTION:
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-dr-richard-chang/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2026/01/dcb-series-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260115T110000
DTEND;TZID=America/Los_Angeles:20260115T120000
DTSTAMP:20260102T214804Z
CREATED:20260102T214619Z
LAST-MODIFIED:20260102T214804Z
UID:54482-1768474800-1768478400@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Jimmy Yilun Zhu
DESCRIPTION:
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-jimmy-yilun-zhu/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2026/01/dcb-series-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251204T110000
DTEND;TZID=America/Los_Angeles:20251204T120000
DTSTAMP:20260826T212028Z
CREATED:20260826T212028Z
LAST-MODIFIED:20260826T212028Z
UID:53282-1764846000-1764849600@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Celina Juliano
DESCRIPTION:Dr. Celina Juliano\n\n\n\nAssociate Professor\, Molecular and Cellular Biology University of California\, Davis \n\n\n\n\n\n\n\n“Mechanisms of development and regeneration in Hydra” \n\n\n\nAbstract: Hydra vulgaris is a small and simple aquatic animal capable of whole-body regeneration. The entire animal\, including the nervous system\, is composed of about 25 cell types\, and can regenerate from a fragment of tissue as small as 300 cells. In addition\, all cell types are continually renewed in the uninjured adult as part of normal homeostasis. These remarkable features are enabled by three distinct populations of stem cells that support the three lineages that make up the adult animal. A major goal of our laboratory is to understand the gene regulatory networks that control the specification of all Hydra vulgaris cell types in the uninjured (homeostatic) state and then understand how injury triggers these differentiation pathways at unexpected locations during regeneration. We are particularly interested in the regeneration of the nervous system and the restoration of neural circuit activity and behaviors. Using high throughput genomics approaches\, we have transcriptionally defined every cell type in Hydra vulgaris and identified putative transcriptional regulators for each cell type. We are currently leveraging these data to conduct functional testing of key putative regulators and to identify injury inputs into cell specification events during regeneration. In addition\, we are investigating a closely related species\, Hydra oligactis\, that has regeneration deficiencies\, which provides a powerful comparative approach to further reveal the molecular mechanisms of regeneration. \n\n\n\nHost: Katie Thompson-Peer & Mia Brantley \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-celina-juliano/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/09/Celina-Juliano.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251120T110000
DTEND;TZID=America/Los_Angeles:20251120T120000
DTSTAMP:20260826T212029Z
CREATED:20260826T212029Z
LAST-MODIFIED:20260826T212029Z
UID:53277-1763636400-1763640000@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Edward Chuong
DESCRIPTION:Dr. Edward Chuong\n\n\n\nAssociate Professor\, Biofrontiers InstituteUniversity of Colorado Boulder \n\n\n\n\n\n\n\n“Transposon-mediated evolution of immune gene regulatory networks” \n\n\n\nAbstract: Mammalian genomes harbor millions of transposon insertions\, but most are expected to be inert or silenced. Despite this\, our research has uncovered numerous transposons that have been co-opted as infection-inducible enhancers and exons for immune genes\, shaping the regulation of host defense responses. These transposons are often species-specific and show context-dependent activity\, providing an evolutionary mechanism for rapid regulatory evolution. The recurrent co-option of transposons as regulatory substrates for immune genes is consistent their role as catalysts for regulatory innovations in the face of pathogen pressure. \n\n\n\nHost: Max Plikus \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-edward-chuong/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/09/Edward-Chuong.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251113T110000
DTEND;TZID=America/Los_Angeles:20251113T120000
DTSTAMP:20260826T212028Z
CREATED:20260826T212028Z
LAST-MODIFIED:20260826T212028Z
UID:53272-1763031600-1763035200@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Xing Dai
DESCRIPTION:Dr. Xing Dai\n\n\n\nProfessor\, SOM – Biological ChemistryUniversity of California\, Irvine \n\n\n\n\n\n\n\n“Beauty is Skin Deep: Epithelial Stem Cell Plasticity\, Immune Crosstalk\, and Metabolism” \n\n\n\nAbstract: Skin is a dynamic organ that relies on the proper regulation of adhesive properties and metabolic activities of epithelial stem and progenitor cells for optimal development\, homeostasis\, and regeneration. I will summarize our work on transcription factors that modulate epithelial-mesenchymal plasticity and how they coordinate epithelial fate with stem cell function. Additionally\, I will discuss our findings on how skin epithelial stem and progenitor cells interact with immune cells to regulate inflammation. Finally\, I will present our recent research on the role of amino acid metabolism in controlling the proliferation and differentiation of skin epithelial stem and progenitor cells. \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-xing-dai/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/09/Xing-Dai.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251106T110000
DTEND;TZID=America/Los_Angeles:20251106T120000
DTSTAMP:20260826T212027Z
CREATED:20260826T212027Z
LAST-MODIFIED:20260826T212027Z
UID:53267-1762426800-1762430400@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Jeff Farrell
DESCRIPTION:Dr. Jeff Farrell\n\n\n\nStadtman Investigator/Assistant ProfessorNIH \n\n\n\n\n\n\n\n“Developmental regulation of best4+ intestinal epithelial cells” \n\n\n\nAbstract: My lab investigates the transcriptional basis of cell fate decisions and cellular function during zebrafish development. We use and develop single-cell genomic approaches to find surprising cell types\, cell states\, or cellular transitions to study with classical developmental and genetic approaches. Recently\, we profiled transcriptionally distinct populations during wild-type zebrafish embryogenesis and early larval development by generating a 489\,000-cell atlas using single-cell RNAseq from 62 developmental stages (3–120 hours post-fertilization)\, which we have made available as the popular resource\, Daniocell. Within this data\, we identified transcriptional profiles of understudied cell types and subpopulations\, including the pneumatic duct\, multiple intestinal smooth muscle cell populations\, spatially distinct pericyte subpopulations\, and homologs of recently discovered human best4+ intestinal epithelial cells. \n\n\n\nSince the function of best4+ cells and the developmental program that gives rise to them remains unknown in any animal\, we have focused on characterizing this cell population. Zebrafish best4+ cells are highly transcriptionally similar to those in humans\, making zebrafish a good model to study these cells in vivo in a genetically tractable\, optically transparent model organism. I will present our results determining the developmental regulation of best4+ cells using both computational developmental trajectory and experimental approaches\, establishing the progenitors that give rise to them\, the developmental signals that specify them\, and key transcription factors that contribute to their gene regulatory network. I will also present our early work using ablation models to establish the function of these cells.  \n\n\n\nHost: Ken Cho \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-jeff-farrell/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/09/Jeff-Farrell.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251030T110000
DTEND;TZID=America/Los_Angeles:20251030T120000
DTSTAMP:20260826T212027Z
CREATED:20260826T212027Z
LAST-MODIFIED:20260826T212027Z
UID:53261-1761822000-1761825600@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Elphege Nora
DESCRIPTION:Dr. Elphege Nora\n\n\n\nAssistant ProfessorUniversity of California\, Irvine \n\n\n\n\n\n\n\n“Molecular Mechanisms of Chromosome Folding and Enhancer Wiring” \n\n\n\nAbstract: I will discuss how cohesin proteins tune chromosomes folding patterns inside cells and how this enables long-range regulation by transcriptional enhancers in pluripotency and during cell differentiation.  \n\n\n\nHost: Evgeny Kvon \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-elphege-nora/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/09/Elphege-Nora.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251023T110000
DTEND;TZID=America/Los_Angeles:20251023T120000
DTSTAMP:20260826T212025Z
CREATED:20260826T212025Z
LAST-MODIFIED:20260826T212025Z
UID:53255-1761217200-1761220800@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Kyoko Yokomori
DESCRIPTION:Dr. Kyoko Yokomori\n\n\n\nProfessor\, SOM – Biological ChemistryUniversity of California\, Irvine \n\n\n\n\n\n\n\n“CRISPR-Engineered mutations and MERFISH single cell spatial transcriptomics reveal key processes of FSHD pathogenesis” \n\n\n\nAbstract: Facioscapulohumeral dystrophy (FSHD) is a third common muscular dystrophy and is linked to contraction of D4Z4 macrosatellite repeats on chromosome 4q with SMCHD1 mutations acting as a disease modifier.  D4Z4 repeats form heterochromatin (DNA methylation and histone H3K9me3)\, and its disruption and abnormal derepression of the transcription factor DUX4 encoded in the D4Z4 repeat are the hallmarks of FSHD.  However\, defining the precise effect of D4Z4 contraction has been difficult because D4Z4 repeats are primate-specific and DUX4 protein expression was found only in <1% of patient myocytes.  We generated isogenic mutant cell lines harboring D4Z4 and/or SMCHD1 mutations in a healthy human skeletal myoblast line using CRISPR-Cas9.  We found that the two mutations affect D4Z4 heterochromatin differently\, and that SMCHD1 mutation or disruption of DNA methylation stabilizes otherwise variegated DUX4 target activation in D4Z4 contraction mutant cells\, demonstrating the critical role of epigenetic modifiers.  We also found amplification of the DUX4 signal through coherent feed-forward mechanism by downstream targets\, such as histone H3 variants\, H3.X/Y\, and the LEUTX transcription factor.  MERFISH-based gene network profiling of multinucleated cells identified FSHD-induced transcriptomic alterations during myoblast differentiation into myotubes.  Patient and mutant myotubes are found in “FSHD-hi” and “FSHD-lo” states with the former signified by high DUX4 target expression and decreased muscle gene expression. Importantly\, both states are distinct from that of control myotubes.  Pseudotime analyses reveal a clear bifurcation of myoblast differentiation into control and FSHD-hi myotube branches with varying numbers of DUX4 target-expressing nuclei. We found that not all DUX4 target genes are expressed equally and that LEUTX represents a sub-pathway within the DUX4 gene network globally increasing DUX4 target gene expression as well as interfering with proper regulations of mitotic and muscle genes during myotube differentiation. Taken together\, our results indicate that heterochromatin loss enables limited expression of DUX4 at D4Z4\, and that its signal is further amplified by downstream target transcription/chromatin factors differentially contributing to the disease transcriptomic phenotype. \n\n\n\nThis work was supported in part by a grant R01AR071287 from National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) \n\n\n\nHost: Elnaz Abdollahzadeh \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-kyoko-yokomori-2/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/09/Kyoko-Yokomori.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251016T110000
DTEND;TZID=America/Los_Angeles:20251016T120000
DTSTAMP:20260826T212026Z
CREATED:20260826T212026Z
LAST-MODIFIED:20260826T212026Z
UID:53248-1760612400-1760616000@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Research in Progress Talk
DESCRIPTION:Research in Progress Talk\n\n\n\n\n\nMia Brantley \n\n\n\nThompson-Peer Lab \n\n\n\n\n\n\n\n“Modeling Real-World Neuronal Injury: How Surrounding Tissue Damage Affects Dendrite Regeneration in Drosophila” \n\n\n\n\n\nDavid Bojorquez \n\n\n\nLara Gonzalez Lab \n\n\n\n\n\n\n\n“Cyclin B3 Orchestrates Early Cell Fate Specification in C. elegans” \n\n\n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-research-in-progress-talk-10-16/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/09/RIP-1016-speakers.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251009T110000
DTEND;TZID=America/Los_Angeles:20251009T120000
DTSTAMP:20260826T212026Z
CREATED:20260826T212026Z
LAST-MODIFIED:20260826T212026Z
UID:53241-1760007600-1760011200@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Research in Progress Talk
DESCRIPTION:Research in Progress Talk\n\n\n\nRosty Brichko \n\n\n\nThompson-Peer Lab \n\n\n\n\n\n\n\n“Investigating Insulin Signaling to Boost Dendrite Regeneration in Adult Neurons” \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-research-in-progress-talk-10-9/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/09/rosty-Brichko-.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251002T110000
DTEND;TZID=America/Los_Angeles:20251002T120000
DTSTAMP:20260826T212025Z
CREATED:20260826T212025Z
LAST-MODIFIED:20260826T212025Z
UID:53234-1759402800-1759406400@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Research in Progress Talk
DESCRIPTION:Research in Progress Talk\n\n\n\n\n\nElnaz Abdollahzadeh \n\n\n\nMortazavi  Lab \n\n\n\n\n\n\n\n“Direct RNA transcriptomic and epitranscriptomic profiling of human brain cortex” \n\n\n\n\n\nRyan Weber \n\n\n\nMortazavi  Lab \n\n\n\n\n\n\n\n“Characterizing cis and trans regulatory variation in diverse mouse strains at single cell resolution” \n\n\n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-research-in-progress-talk-10-2/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/09/RIP-102-speakers.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250925T110000
DTEND;TZID=America/Los_Angeles:20250925T120000
DTSTAMP:20260826T212027Z
CREATED:20260826T212027Z
LAST-MODIFIED:20260826T212027Z
UID:53229-1758798000-1758801600@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Evgeny Kvon
DESCRIPTION:Dr. Evgeny Kvon\n\n\n\nAssistant Professor\, Department of Developmental and Cell Biology University of California\, Irvine \n\n\n\n\n\n\n\n“How Variation in Non-Protein-Coding Regions of Our Genomes Contributes to Disease” \n\n\n\nAbstract: Our genomes contain crucial yet poorly understood regulatory sequences called enhancers. While the coding sequence of a gene determines the type of protein produced\, enhancers control the amount of protein produced and the specific cell types in which production happens. Nearly 90% of genetic variation linked to disease is found in non-coding DNA\, with much of it believed to affect enhancer function. So\, understanding how enhancers work is vital for making sense of vast genomic data and developing personalized treatments for genetic disorders. We use a combination of mouse genome engineering and genomics tools to tackle two questions in developmental gene regulation: 1. How do enhancers activate their target genes over long genomic distances? and 2. How do mutations in enhancers lead to human disease? \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-evgeny-kvon/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/08/Evgeny-Kvon-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250605T110000
DTEND;TZID=America/Los_Angeles:20250605T120000
DTSTAMP:20260826T212127Z
CREATED:20260826T212127Z
LAST-MODIFIED:20260826T212127Z
UID:51621-1749121200-1749124800@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Kyoko Yokomori
DESCRIPTION:Dr. Kyoko Yokomori\n\n\n\nProfessor\, SOM – Biological ChemistryUniversity of California\, Irvine \n\n\n\n\n\n\n\n“CRISPR-Engineered mutations and MERFISH single cell spatial transcriptomics reveal key processes of FSHD pathogenesis” \n\n\n\nAbstract: Facioscapulohumeral dystrophy (FSHD) is a third common muscular dystrophy and is linked to contraction of D4Z4 macrosatellite repeats on chromosome 4q with SMCHD1 mutations acting as a disease modifier.  D4Z4 repeats form heterochromatin (DNA methylation and histone H3K9me3)\, and its disruption and abnormal derepression of the transcription factor DUX4 encoded in the D4Z4 repeat are the hallmarks of FSHD.  However\, defining the precise effect of D4Z4 contraction has been difficult because D4Z4 repeats are primate-specific and DUX4 protein expression was found only in <1% of patient myocytes.  We generated isogenic mutant cell lines harboring D4Z4 and/or SMCHD1 mutations in a healthy human skeletal myoblast line using CRISPR-Cas9.  We found that the two mutations affect D4Z4 heterochromatin differently\, and that SMCHD1 mutation or disruption of DNA methylation stabilizes otherwise variegated DUX4 target activation in D4Z4 contraction mutant cells\, demonstrating the critical role of epigenetic modifiers.  We also found amplification of the DUX4 signal through coherent feed-forward mechanism by downstream targets\, such as histone H3 variants\, H3.X/Y\, and the LEUTX transcription factor.  MERFISH-based gene network profiling of multinucleated cells identified FSHD-induced transcriptomic alterations during myoblast differentiation into myotubes.  Patient and mutant myotubes are found in “FSHD-hi” and “FSHD-lo” states with the former signified by high DUX4 target expression and decreased muscle gene expression. Importantly\, both states are distinct from that of control myotubes.  Pseudotime analyses reveal a clear bifurcation of myoblast differentiation into control and FSHD-hi myotube branches with varying numbers of DUX4 target-expressing nuclei. We found that not all DUX4 target genes are expressed equally and that LEUTX represents a sub-pathway within the DUX4 gene network globally increasing DUX4 target gene expression as well as interfering with proper regulations of mitotic and muscle genes during myotube differentiation. Taken together\, our results indicate that heterochromatin loss enables limited expression of DUX4 at D4Z4\, and that its signal is further amplified by downstream target transcription/chromatin factors differentially contributing to the disease transcriptomic phenotype. \n\n\n\nThis work was supported in part by a grant R01AR071287 from National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) \n\n\n\nHost: Elnaz Abdollahzadeh \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-kyoko-yokomori/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/04/Developmental-and-Cell-Biology-Seminar-Series-Dr.-Kyoko-Yokomori.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250529T110000
DTEND;TZID=America/Los_Angeles:20250529T120000
DTSTAMP:20260826T212128Z
CREATED:20260826T212128Z
LAST-MODIFIED:20260826T212128Z
UID:51564-1748516400-1748520000@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Dennis Discher 
DESCRIPTION:Dr. Dennis Discher \n\n\n\nRobert D. Bent ProfessorUniversity of Pennsylvania \n\n\n\n\n\n\n\n“Mechanobiological insights into fat\, genome integrity\, and tumoricidal macrophages” \n\n\n\nAbstract: Fat is usually considered soft\, but fat droplets accumulate within cells and remain round as they displace\, deform\, and simply dominate organelles including the nuclear envelope. The latter ruptures when nuclear lamina proteins are low and impinging fat droplets have high curvature\, thus causing loss of DNA repair factors to cytoplasm and DNA damage. In related contexts and with a focus on solid tumors\, we study signaling to macrophages. We find that pushing a tumoricidal phenotype favors macrophage clustering and cooperation of ‘intrudo-podia’ that disrupt solid tumors for engulfment and anticancer immunity. \n\n\n\nHost: Yinyin Zhuang \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-dennis-discher/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/03/Developmental-and-Cell-Biology-Seminar-Series-Dr.-Dennis-Discher-.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250515T110000
DTEND;TZID=America/Los_Angeles:20250515T120000
DTSTAMP:20260826T212030Z
CREATED:20260826T212030Z
LAST-MODIFIED:20260826T212030Z
UID:51553-1747306800-1747310400@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Scott Atwood
DESCRIPTION:Dr. Scott Atwood\n\n\n\nAssociate Professor\, Developmental & Cell BiologyUniversity of California\, Irvine \n\n\n\n\n\n\n\n“Defining tumor recognition and regression in basal cell carcinoma” \n\n\n\nAbstract: The Atwood lab is interested in how skin cancer develops and the ways to therapeutically suppress tumor growth. How normal tissue can suppress oncogenic outgrowth is of recent interest. This seminar will explore how basal cell carcinoma may be initially recognized by the tissue microenvironment and how the immune system interacts with normal and oncogenic tissue to suppress tumor progression. \n\n\n\nHost: Yi Wang \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-scott-atwood/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/03/Scott-Atwood-speaker.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250508T110000
DTEND;TZID=America/Los_Angeles:20250508T120000
DTSTAMP:20260826T212128Z
CREATED:20260826T212128Z
LAST-MODIFIED:20260826T212128Z
UID:51546-1746702000-1746705600@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Ru Gunawardane
DESCRIPTION:Dr. Ru Gunawardane\n\n\n\nExecutive DirectorAllen Institute for Cell Science   \n\n\n\n\n\n\n\n“Towards understanding cell states and transitions in hiPSCs: an integrated spatiotemporal approach” \n\n\n\nAbstract: The Allen Institute for Cell Science aims to understand the principles by which human induced pluripotent stem cells (hiPSCs) establish and maintain robust dynamic localization of cellular structures\, and how the cells transition between states during differentiation. Towards this aim\, we created a collection of fluorescent-tagged clonal hiPSC lines (Allen Cell Collection) using CRISPR/Cas9 to fluorescently tag proteins that localize to the major organelles of the cell using the WTC-11 hiPSC parental line. Live 3D imaging\, single cell image analysis\, quantitation\, modeling\, visualization\, and open distribution define our endeavor. We have generated fluorescently tagged hiPSC clonal lines for 58 cellular organelles/structures and performed key genetic\, cell biological\, and stem cell validation. Using these cell lines\, we have imaged and quantified distinct aspects of intracellular organization in hiPSCs including the variation of intracellular organization in single cells across the hiPSC population. I will highlight a couple of use cases for these tools including the epithelial-mesenchymal transition (EMT)\, a fundamental process in development that is also observed during early mesoderm differentiation of hiPSCs. Using this model system\, we are interrogating the interplay between cell organization\, cell behavior\, the molecular components\, and the environment to define a more holistic cell state. We also characterized sarcomere organization in hiPSC-derived cardiomyocytes and the relationship to key cardiac markers associated with differentiation and maturation. We are expanding these studies to hiPSC-derived endothelial cells and 3D lumenoids by developing novel experimental and computational approaches to understand rules of morphogenesis. Our cell lines\, plasmids\, 3D images\, various analysis and visualization tools\, integrated cell models\, and biological findings are available to the research community (www.allencell.org).  \n\n\n\nHost: Ken Cho \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-ru-gunawardane/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/03/DCB-Seminar.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250502T110000
DTEND;TZID=America/Los_Angeles:20250502T123000
DTSTAMP:20260826T212030Z
CREATED:20260826T212030Z
LAST-MODIFIED:20260826T212030Z
UID:52120-1746183600-1746189000@www.bio.uci.edu
SUMMARY:A Role for Water Transport in the Regulation of the Optical Power in the Developing Mammalian and Zebrafish Lens: Professor Paul Donaldson and Dr. Irene Vorontsova
DESCRIPTION:Professor Donaldson\n\n\n\nDirector of the Molecular Vision Research ClusterUniversity of Auckland \n\n\n\n\n\n\n\n\n\nDr. Irene Vorontsova\n\n\n\nResearch FellowUniversity of Auckland \n\n\n\n\n\n\n\n\n\n“A role for water transport in the regulation of the optical power in the developing mammalian and zebrafish lens” \n\n\n\nAbstract: In this seminar Professor Paul Donaldson and Dr Irene Vorontsova from the Molecular Vision Research Cluster at the University of Auckland\, New Zealand\, will each present on their ongoing research into how water transport establishes\, maintains\, and modulates the refractive power of the ocular lens to ensure that light is corrected focussed on the retina as the eye grows.  Professor Donaldson will first provide an overview of how the adult lens generates an internal microcirculation system that generations a circulating flux of ions and water which has been shown to regulate the optical power of the lens by controlling the volume (geometry) and water to protein ratio (refractive index gradient)\, the two key factors that determine lens power. He will then discuss how changes to the key proteins (Aquaporin water channels\, gap junctions) involved in lens water transport change during the phases of embryonic and postnatal development that occur before eye opening in the mouse lens. Then after eye opening\, how the optical properties of the lens change to ensure that light is corrected focussed on the retina as the mouse eye grows. \n\n\n\nDr Vorontsova will then present insights from zebrafish into mechanisms of how water transport mediated by aquaporin 0a (Aqp0a) regulates the formation of lens anatomy and optics and how this system is being utilized to learn about optical development and what may lead to refractive error\, such as myopia. Besides determining the water to protein ratio that ultimately determines the refractive index\, Aqp0a also regulates the shift of the lens nucleus from an initial anterior location to a central location during development\, as well as determines the morphology of the lens sutures – a junction at the poles of the lens where the elongated lens fibre cells meet. By studying the mechanisms that coordinate optical development with axial length\, our work will provide not only new insights into normal optical development\, but also how its dysfunction can lead to refractive error. \n\n\n\nSeminar will be held in person only. 
URL:https://www.bio.uci.edu/event/professor-paul-donaldson-and-dr-irene-vorontsova/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bio.uci.edu/wp-content/uploads/2025/04/May-2025-zebrafish-thumbnail.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250417T110000
DTEND;TZID=America/Los_Angeles:20250417T120000
DTSTAMP:20260826T212031Z
CREATED:20260826T212031Z
LAST-MODIFIED:20260826T212031Z
UID:51657-1744887600-1744891200@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Joshua Alcantara and Melissa Campos
DESCRIPTION:Joshua Alcantara\n\n\n\nKvon  Lab \n\n\n\n\n\n\n\n“Dissecting how redundant transcriptional enhancers ensure robustness of mammalian embryogenesis” \n\n\n\nMelissa Campos\n\n\n\nAlbrecht Lab \n\n\n\n\n\n\n\n“Lysosomal compartmentalization of phosphofructokinase-1 regulates skeletal muscle metabolism” \n\n\n\nSeminars will be in person only.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-joshua-alcantara-and-melissa-campos-2/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/04/Developmental-and-Cell-Biology-Seminar-Series-Joshua-Alcantara-and-Melissa-Campos-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250410T110000
DTEND;TZID=America/Los_Angeles:20250410T120000
DTSTAMP:20260826T212126Z
CREATED:20260826T212126Z
LAST-MODIFIED:20260826T212126Z
UID:51640-1744282800-1744286400@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Guan-Yin Stevens and Yikai Huang
DESCRIPTION:Guan-Yin Stevens\n\n\n\nArora and Warrior Labs \n\n\n\n\n\n\n\n“Analyzing the transcriptional regulatory strategy of Dawdle\, a TGF-β ligand essential for sugar homeostasis in Drosophila”  \n\n\n\nYikai Huang\n\n\n\nBlumberg  Lab \n\n\n\n\n\n\n\n“Transgenerational Obesity Induced by Prenatal Tributyltin Exposure Is Exacerbated by Diet and Associated with Reduced Thermogenic Activity” \n\n\n\nSeminars will be in person only. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-guan-yin-stevens-and-yikai-huang/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/04/Developmental-and-Cell-Biology-Seminar-Series-Guan-Yin-Stevens-and-Yikai-Huang.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250403T110000
DTEND;TZID=America/Los_Angeles:20250403T120000
DTSTAMP:20260826T212127Z
CREATED:20260826T212127Z
LAST-MODIFIED:20260826T212127Z
UID:51521-1743678000-1743681600@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Travis Thomson
DESCRIPTION:Dr. Travis Thomson\n\n\n\n Assistant ProfessorUniversity of Massachusetts  \n\n\n\n\n\n\n\n“Dueling Transposons Regulate Structural Synaptic Plasticity” \n\n\n\nAbstract: Transposons are parasitic genome elements that can also serve as raw material for the evolution of new cellular functions. However\, how retrotransposons are selected and domesticated by host organisms to modulate synaptic plasticity remains largely unknown. Here\, we show that the Ty1 retrotransposon Copia forms virus-like capsids in vivo and transfers between cells. Copia is enriched at the Drosophila neuromuscular junction (NMJ) and transported across synapses\, and disrupting its expression promotes both synapse development and structural synaptic plasticity. We show that proper synaptic plasticity is maintained in Drosophila by the balance of Copia and the Arc1 (activity-regulated cytoskeleton-associated protein) homolog. High-resolution cryogenic-electron microscopy imaging shows that the structure of the Copia capsid has a large capacity and pores like retroviruses but is distinct from domesticated capsids such as dArc1. Our results suggest a fully functional transposon mediates synaptic plasticity\, possibly representing an early stage of domestication of a retrotransposon. \n\n\n\nHost: Prof. Nick Baker \n\n\n\nSeminar will be via Zoom \n\n\n\nMeeting ID: 935 0482 6445Passcode:754037 \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-travis-thomson/
LOCATION:CA
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/04/Developmental-and-Cell-Biology-Seminar-Series-Dr.-Travis-Thomson.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231019T110000
DTEND;TZID=America/Los_Angeles:20231019T120000
DTSTAMP:20260826T212250Z
CREATED:20260826T212250Z
LAST-MODIFIED:20260826T212250Z
UID:43358-1697713200-1697716800@www.bio.uci.edu
SUMMARY:DCB Seminar Series Featuring Dr. Doina Tumbar from Cornell University
DESCRIPTION:Fall 2023 Seminar Series \nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201\, and live streamed via Zoom.  For seminar schedule click here. \n\nDr. Doina Tumbar\nProfessor\, Molecular Biology and Genetics\nCornell University\n\n“Epithelial skin stem cells in action: cell intrinsic and niche related mechanisms“\nAbstract:\nWe are studying basic cellular and molecular mechanisms that regulate tissue stem cell activity\, focusing on adult epithelial stem cells in the skin. Using genetic and genomic approaches in mouse skin and comparing with human skin\, we are mapping the organization and regulation of hair follicle and epidermal stem cells and their interaction with the microenvironment or ‘niche’. We are analyzing genetic control of stem cell activation\, self-renewal\, and differentiation. Our general focus is on stem cell fate choice by epigenetic regulation\, transcription regulation via specific developmental transcription factors and RNA Pol II Pausing mechanisms\, and chromatin modifying factors. We are particularly fascinated by the role of epithelial stem cells in organizing cells in their surrounding environment\, such as melanocytes\, blood vessels\, nerves\, fat cells\, and fibroblast. Additionally\, we explore how our findings in mice might apply to normal and diseased human skin.\n\nOrganizer:\nEmail: Mayra Rubio mrubio3@uci.edu\n\n 
URL:https://www.bio.uci.edu/event/dcb-seminar-series-featuring-dr-doina-tumbar-from-cornell-university/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, CA\, United States
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2023/08/Dr.-Doina-Tumbar-1000x1000-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231005T110000
DTEND;TZID=America/Los_Angeles:20231005T120000
DTSTAMP:20260826T212249Z
CREATED:20260826T212249Z
LAST-MODIFIED:20260826T212249Z
UID:43350-1696503600-1696507200@www.bio.uci.edu
SUMMARY:DCB Seminar Series Featuring Dr. Justin Shaffer from Colorado School of Mines
DESCRIPTION:Fall 2023 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201\, and live streamed via Zoom.  For seminar schedule click here. \n\n\n\nDr. Justin Shaffer \n\n\n\n\n\n\n\nTeaching ProfessorChemical and Biological Engineering DepartmentQuantitative Biosciences and Engineering ProgramColorado School of Mines\n\n\n\nAbstract:\n\n\n\nCalls for using evidence-based pedagogies have been expanding so as to improve student learning and outcomes. High structure courses are designed to do just that as they prepare students to be actively engaged in the learning process via pre-class content acquisition and assessment\, in-class active learning and problem solving\, after-class review and assessment\, and frequent summative exams or quizzes. Significant literature has showed high structure courses in a variety of STEM disciplines to be efficacious as students show increased performance\, achievement gaps are narrowed or closed\, and students feel more belonging. This talk will synthesize research done over the past eight years from two different universities (UC Irvine and the Colorado School of Mines)\, three different disciplines (introductory biology\, anatomy and physiology\, and chemical engineering)\, and many different types of courses that served thousands of students. Practical tips will be provided for instructors who want to adapt high structure principles for their own courses. \n\n\n\nOrganizer:Email: Mayra Rubio mrubio3@uci.edu
URL:https://www.bio.uci.edu/event/dcb-seminar-series-featuring-dr-justin-shaffer-from-colorado-school-of-mines/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, CA\, United States
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2023/08/Dr.-Justin-Shaffer-1000x1000-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230928T110000
DTEND;TZID=America/Los_Angeles:20230928T120000
DTSTAMP:20260826T212249Z
CREATED:20260826T212249Z
LAST-MODIFIED:20260826T212249Z
UID:43068-1695898800-1695902400@www.bio.uci.edu
SUMMARY:DCB Seminar Series Featuring Dr. Xu Li from Westlake University
DESCRIPTION: \nFall 2023 Seminar Series \nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201\, and live streamed via Zoom.  For seminar schedule click here. \n\nDr. Xu Li\n \n\nAssistant Professor\, School of Life Sciences\, Westlake University\n \nAbstract:\n\nAdvances in high-throughput techniques has revolutionized biomedical research by creating avenues for integrated system-level approaches\, revealed mechanisms driving diseases and suggested novel targeted therapies. To effectively utilize proteomics data to guide in-depth mechanistic studies in development and diseases\, we developed several new techniques and algorithms\, such as ACUMEN-APEX2/TurboID and Minkowski distance-based algorithm MUSE\, to generate high-quality\, spatial- and tempol-precise protein-protein interaction networks in diseases models. Using these networks\, we studied the composition and reprogramming of key signaling networks in development and cancers such as acute T lymphoblastic leukemia. Our research revealed novel mechanisms and provided biomarkers and drug targets for the diagnosis and treatment of such tumors. \n \nOrganizer:\nEmail: Mayra Rubio mrubio3@uci.edu
URL:https://www.bio.uci.edu/event/dcb-seminar-series-featuring-dr-xu-li-from-westlake-university/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, CA\, United States
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2023/07/Xu-Li-1000x1000-1.png
END:VEVENT
END:VCALENDAR