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DTSTART;TZID=America/Los_Angeles:20250403T110000
DTEND;TZID=America/Los_Angeles:20250403T120000
DTSTAMP:20260826T212128Z
CREATED:20260826T212128Z
LAST-MODIFIED:20260826T212128Z
UID:51571-1743678000-1743681600@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Travis Thompson
DESCRIPTION:Dr. Travis Thompson\n\n\n\nAssistant ProfessorUniversity of Massachusetts 
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-travis-thompson/
LOCATION:California
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250403T110000
DTEND;TZID=America/Los_Angeles:20250403T120000
DTSTAMP:20260826T212127Z
CREATED:20260826T212127Z
LAST-MODIFIED:20260826T212127Z
UID:51521-1743678000-1743681600@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Travis Thomson
DESCRIPTION:Dr. Travis Thomson\n\n\n\n Assistant ProfessorUniversity of Massachusetts  \n\n\n\n\n\n\n\n“Dueling Transposons Regulate Structural Synaptic Plasticity” \n\n\n\nAbstract: Transposons are parasitic genome elements that can also serve as raw material for the evolution of new cellular functions. However\, how retrotransposons are selected and domesticated by host organisms to modulate synaptic plasticity remains largely unknown. Here\, we show that the Ty1 retrotransposon Copia forms virus-like capsids in vivo and transfers between cells. Copia is enriched at the Drosophila neuromuscular junction (NMJ) and transported across synapses\, and disrupting its expression promotes both synapse development and structural synaptic plasticity. We show that proper synaptic plasticity is maintained in Drosophila by the balance of Copia and the Arc1 (activity-regulated cytoskeleton-associated protein) homolog. High-resolution cryogenic-electron microscopy imaging shows that the structure of the Copia capsid has a large capacity and pores like retroviruses but is distinct from domesticated capsids such as dArc1. Our results suggest a fully functional transposon mediates synaptic plasticity\, possibly representing an early stage of domestication of a retrotransposon. \n\n\n\nHost: Prof. Nick Baker \n\n\n\nSeminar will be via Zoom \n\n\n\nMeeting ID: 935 0482 6445Passcode:754037 \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/developmental-and-cell-biology-seminar-series-dr-travis-thomson/
LOCATION:California
CATEGORIES:Events,Seminars
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/04/Developmental-and-Cell-Biology-Seminar-Series-Dr.-Travis-Thomson.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250318T160000
DTEND;TZID=America/Los_Angeles:20250318T180000
DTSTAMP:20260826T212246Z
CREATED:20260826T212246Z
LAST-MODIFIED:20260826T212246Z
UID:50855-1742313600-1742320800@www.bio.uci.edu
SUMMARY:Dean's Distinguished Lecture - Winter 2025
DESCRIPTION:Using Neuroscience to Transform Our Understanding of DepressionJoin us for a talk with Diego Pizzagalli\, PhD\n\n\n\n\n\n \n\n\n\nYou are invited to the Charlie Dunlop School of Biological Sciences’ Dean’s Distinguished Lecture Series\, featuring Diego Pizzagalli\, PhD on March 18\, 2025\, in the Crystal Cove Auditorium at the UCI Student Center. \n\n\n\nDepression has become the leading cause of disability worldwide\, and its prevalence has increased substantially\, particularly among adolescents and young adults. Over the past decade\, there has been substantial progress in our understanding of possible causes of depression. In particular\, there have been breakthroughs in our ability to study the human brain that have allowed researchers and clinicians to identify individuals at increased risk for depression\, develop new treatments\, and identify biological markers that could be used to guide treatment. In this presentation\, Dr. Pizzagalli will summarize main risk factors for depression as well as examples of how findings in neuroscience have been harnessed to develop novel treatment approaches for this prevalent disorder. \n\n\n\n\n\n\n\n\n\n\n\n\nRegister to Attend the Dean’s Distinguished Lecture:\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nAbout Diego Pizzagalli\, PhD\n\n\n\n\n\n\n\nDr. Pizzagalli received his M.A. (1995) and Ph.D. (1998) from the University of Zurich\, Switzerland and did post-doctoral work at University of Wisconsin\, Madison. From 2002-2010 he was a faculty member in the Department of Psychology at Harvard University\, where he served as the John and Ruth Hazel Associate Professor of the Social Sciences. In 2010\, he was recruited to McLean Hospital to serve as the Founding Director of the Center for Depression\, Anxiety and Stress Research (CDASR)\, as well as the Director of the McLean Imaging Center (MIC). Until 12/2024\, Dr. Pizzagalli was a Professor of Psychiatry at Harvard Medical School\, and the Center Director for a Silvio O. Conte Center for Basic Translational Mental Health Research focused on the neurobiology of and novel treatment targets for depression and anxiety disorders. Since 2024\, he is also a Visiting Professor at the University of Oxford\, UK.  In 2025\, he joined the University of California at Irvine as the Founding Director of the Noel Drury\, M.D. Institute for Translational Depression Discoveries\, a Distinguished Professor in the Department of Psychiatry and Human Behavior and the Department of Neurobiology and Behavior\, and the Noel Drury MD Endowed Chair. \n\n\n\nClick to read more\nThe main goals of his research are to improve our understanding of the psychological\, environmental\, and neurobiological factors associated with mood disorders\, particularly major depression. To this end\, he integrates behavioral\, electrophysiological\, neuroimaging\, and\, more recently\, pharmacological approaches to investigate three putative endophenotypes of depression: anhedonia (loss of pleasure)\, increased stress sensitivity\, and executive function deficits. Dr. Pizzagalli has published over 360 papers and chapters and serves on the editorial board of 13 journals. He is the Editor-In-Chief for the journal Cognitive\, Affective and Behavioral Neuroscience. Among several awards\, he received the Distinguished Scientific Award for an Early Career Contribution to Psychophysiology from the Society for Psychophysiological Research (2006)\, the Early Career Award from the EEG and Clinical Neuroscience Society (2007)\, the Anne M. Cataldo Excellence in Mentoring Award from McLean Hospital (2015)\, two MERIT awards from the National Institute of Mental Health (2016\, 2022)\, The Stuart T. Hauser\, M.D. PhD. Mentorship Award in Psychiatry from Harvard Medical School (2017)\, the Joel Elkes Research Award from the American College of Neuropsychopharmacology (2017)\, a NARSAD Distinguished Investigator Award (2018)\, the Anna-Monika-Prize for Research in the Neurobiology and Treatment of Depressive Disorders (2019)\, the Gerald L. Klerman Senior Investigator Award from the Depression and Bipolar Support Alliance (2023)\, and the Christensen Fellowship from the University of Oxford (2024). Since 2019\, he has been a Highly Cited Researcher according to Web of Science. \n\n\n\n\n\n\n\n\n\n\n\n\nIf you have questions about this event\, please email biosci-events@uci.edu.
URL:https://www.bio.uci.edu/event/deans-distinguished-lecture-winter-2025/
LOCATION:Crystal Cove Auditorium – UCI Student Center\, 4113 Pereira Dr.\, Irvine\, California\, 92697\, United States
CATEGORIES:Dean's Distinguished Lecture,Events
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/01/Diego-Pizzagalli-Featured-Image.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250313T110000
DTEND;TZID=America/Los_Angeles:20250313T120000
DTSTAMP:20260826T212322Z
CREATED:20260826T212322Z
LAST-MODIFIED:20260826T212322Z
UID:50735-1741863600-1741867200@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Karen Schindler 
DESCRIPTION:Dr. Karen Schindler \n\n\n\nProfessorRutgers University\n\n\n\n\n\n\n\n“Determining the genetic contributions to aneuploidy in eggs”\n\n\n\nAbstract: A healthy egg is essential for a successful pregnancy and full-term development. The chromosome content of the egg and sperm is an exquisitely important characteristic: a single extra or missing chromosome in the embryo typically leads to arrested development and miscarriage (i.e.\, spontaneous abortion or pregnancy loss). Such numerical chromosomal abnormalities\, termed “aneuploidies\,” are most often found in the egg; approximately 10-25% of eggs in reproductive-age individuals are aneuploid and are the leading genetic cause of early miscarriage. My talk will focus on our work that aims to understand the basic mechanisms that control chromosome segregation in eggs and to identify genetic mutations that lead to extreme egg aneuploidy in humans. \n\n\n\nHost: Kathleen Leon Parada \n\n\n\nSeminar will be held in person only. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-karen-schindler/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/01/dr-karen-schindler.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250306T110000
DTEND;TZID=America/Los_Angeles:20250306T120000
DTSTAMP:20260826T212248Z
CREATED:20260826T212248Z
LAST-MODIFIED:20260826T212248Z
UID:50724-1741258800-1741262400@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Xin Jin
DESCRIPTION:Dr. Xin Jin\n\n\n\nAssociate Professor\, Department of NeuroscienceScripps Research\n\n\n\n\n\n\n\n“Scalable investigation of gene function and organ-wide action with in vivo Perturb-seq”\n\n\n\nAbstract: Human genetics have identified long lists of risk genes and loci associated with diseases\, including neurodegenerative diseases and aging\, and the next challenge is to identify their shared impacts and patterns of etiology for therapeutic designs. These genetic analyses are best performed in vivo where the age-dependent organismal physiology is intact. However\, systematic analysis of gene function across diverse cell types in vivo is still hindered by at least two challenges: obtaining sufficient cells from live tissues and accurately identifying each cell’s perturbation in high-throughput single-cell assays. Leveraging AAV’s versatile cell type tropism and high labeling capacity\, we expanded the resolution and scale of in vivo CRISPR screens: allowing phenotypic analysis at single-cell resolution across a multitude of cell types in the embryonic brain\, adult brain\, and peripheral nervous system. We undertook extensive tests of 86 AAV serotypes\, combined with a transposon system\, to substantially amplify labeling and accelerate in vivo gene delivery from weeks to days. Using this platform\, we performed an in vivo genetic screen as proof-of-principle and identified pleiotropic regulatory networks of Foxg1\, including their impact on Layer 6 corticothalamic neurons where it tightly controls distinct networks essential for cell fate specification and function. Notably\, our platform can label >6% of cerebral cells\, surpassing the current state-of-the-art efficacy at <0.1% (mediated by lentivirus)\, and achieve analysis of over 30\,000 cells in one experiment\, thus enabling massively parallel in vivo Perturb-seq. Compatible with various perturbation techniques (CRISPRa/i) and phenotypic measurements (single-cell or spatial multi-omics)\, our platform presents a flexible\, modular approach to interrogate gene function across diverse cell types in vivo\, translating gene variants to their causal functions. \n\n\n\nHost: Ethan Hollingsworth \n\n\n\nSeminar will be held in person only. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-xin-jin/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/01/Dr-Xin-Jin.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250227T110000
DTEND;TZID=America/Los_Angeles:20250227T120000
DTSTAMP:20260826T212325Z
CREATED:20260826T212325Z
LAST-MODIFIED:20260826T212325Z
UID:50719-1740654000-1740657600@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Martin Cohn
DESCRIPTION:Dr. Martin Cohn\n\n\n\nProfessor\, Department of Molecular Genetics & MicrobiologyUniversity of Florida
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-martin-cohn/
LOCATION:California
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250220T160000
DTEND;TZID=America/Los_Angeles:20250220T170000
DTSTAMP:20260826T211653Z
CREATED:20250207T214743Z
LAST-MODIFIED:20260826T211653Z
UID:50936-1740067200-1740070800@www.bio.uci.edu
SUMMARY:Donuts with the Dean: Winter 2024
DESCRIPTION:Join us for the return of Dunlop BioSci’s quarterly Donuts with the Dean!\n\n\n\nPlease join us on Thursday\, October 24 from 4 – 5 p.m. on the 5th Floor of Natural Sciences II. \n\n\n\nJoin Dean Frank LaFerla and hear from our guest speaker\, Nan Wu Hultgren\, PhD. Afterwards\, enjoy a donut and fruit\, while talking to Dunlop School faculty\, students and our speaker \n\n\n\nAbout the Speaker:\n\n\n\n\n\n\n\nOriginally from Hangzhou\, China\, Nan Wu Hultgren\, Ph.D.\, came to the U.S. alone to pursue a bachelor’s degree in molecular and cell biology at California State University. Her passion for research was ignited by her professor\, Dr. Christoph Baysdorfer\, and led her to earn a Ph.D. in vascular biology at UC Irvine in 2018 under the mentorship of Dr. Christopher Hughes. Her doctoral research on the transcription factor Slug in sprouting angiogenesis earned prestigious recognition\, including the ARCS Award\, an AHA Predoctoral Fellowship\, and an NIH F31 Predoctoral Fellowship\, resulting in several widely cited publications. \n\n\n\nRead more below\nNan continued her scientific journey as a postdoctoral researcher at UCLA\, where she studied mitochondrial dynamics and organellar interactions in retinal pigmented epithelial cells. Committed to excellence in research and mentorship—particularly for first-generation and underrepresented students—she was awarded the NIH F32 Postdoctoral Fellowship and the NIH IRACDA Postdoctoral Fellowship. \n\n\n\nInspired by her experiences in graduate school\, especially the mentorship and support she received as an ARCS Scholar\, Nan and her husband\, Eric\, are dedicated to giving back. They actively support current and future graduate students by funding childcare and resources to enable participation in academic and professional conferences. Nan has also served as a Board of Directors member and Chapter President of the ARCS Foundation\, a nationwide women-led STEM advocacy group. \n\n\n\nUpon completing her postdoctoral training under the NIH K99/R00 Fellowship\, Nan hopes to establish her own independent research program focusing on organellar dynamics and cellular mechanisms in degenerative diseases. Meanwhile\, she remains committed to fostering curiosity\, creativity\, and ethical leadership in the next generation of scientists\, ensuring that diversity and individuality are celebrated in STEM. \n\n\n\n\n\n\n\n\n\n\n\n\n \n\n\n\n\nRegister
URL:https://www.bio.uci.edu/event/donuts-with-the-dean-winter-2025/
LOCATION:Natural Sciences II\, 5th Floor Lobby\, 5120 Natural Sciences II\, Irvine\, California\, 92697
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250220T110000
DTEND;TZID=America/Los_Angeles:20250220T120000
DTSTAMP:20260826T212322Z
CREATED:20260826T212322Z
LAST-MODIFIED:20260826T212322Z
UID:50715-1740049200-1740052800@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Fan Yang
DESCRIPTION:Dr. Fan Yang\n\n\n\nAssociate Professor\, Assistant Dean in the School of Basic Medical SciencesZhejiang University\n\n\n\n\n\n\n\n“From atoms to animals: Rational design of novel modulators to TRP ion channels for analgesia”\n\n\n\nAbstract: The Transient Receptor Potential (TRP) ion channels serve as thermoreceptors and nociceptors in the human body. To investigate how these channels are activated by temperature and various pain-inducing compounds\, we employ a multidisciplinary suite of biophysical techniques. These include patch-clamp recordings\, single-particle cryo-electron microscopy\, fluorescent non-natural amino acid imaging\, and computational modeling. \n\n\n\nOur findings reveal that conformational changes in critical residues of TRP channels alter protein-water interactions\, which are fundamental to their temperature activation. Conversely\, compounds modulate channel activity by binding to specific “hot spots” within the TRP channels. \n\n\n\nDrug development targeting TRP channels has been historically challenging due to the side effect of altering body temperature when these channels are directly inhibited. Leveraging our understanding of TRP channel mechanisms\, we have rationally designed TRP-targeting peptides\, such as s-RhTx and DeC-1.2\, which exhibit analgesic effects in animal pain models without impacting body temperature. \n\n\n\nAdditionally\, we have rationally engineered the TRPM8 channel\, known for its permeability to calcium ions\, to function as a tool for manipulating calcium-dependent cellular activities in the brain to influence animal behavior. We believe that our foundational research on TRP channels will significantly advance translational applications\, including the development of innovative drugs and tools. \n\n\n\nHost: Xiaoyu Shi \n\n\n\nSeminar will be held in person only. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-fan-yang/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250213T110000
DTEND;TZID=America/Los_Angeles:20250213T120000
DTSTAMP:20260826T212321Z
CREATED:20260826T212321Z
LAST-MODIFIED:20260826T212321Z
UID:50710-1739444400-1739448000@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Yongdeng Zhang
DESCRIPTION:Dr. Yongdeng Zhang\n\n\n\nAssistant Professor\, School of Life SciencesWestlake University\n\n\n\n\n\n\n\n“Elucidating subcellular architecture and dynamics with super-resolution microscopy”\n\n\n\nAbstract: Super-resolution microscopy plays a crucial role in elucidating the intricate molecular mechanisms underlying diverse biological processes. Here\, we present the development of a highly efficient multicolor 4Pi-SMS technique that enables the acquisition of 3D super-resolution images of whole mammalian cells with a resolution of approximately 10 nm. When combined with expansion microscopy\, molecular-level resolution (<5 nm) can be achieved. Additionally\, notable progress has been made in attaining high-quality 3D super-resolution imaging of biological tissue samples. This involves the utilization of multi-line scanning illumination and confocal detection to reduce out-of-focus background\, as well as deep-learning-enabled aberration correction with adaptive optics. Furthermore\, by combining 4Pi microscopy with 3D structured illumination microscopy\, we implemented 4Pi-SIM\, which achieved time-lapse volumetric isotropic 100 nm resolution in 3D in living cells. Through imaging a variety of biological samples\, we demonstrated that 4Pi-SIM enables the visualization of subcellular structures with excellent clarity and detail. These developments hold great potential for elucidating subcellular architecture and revealing dynamic behaviors to enhance our comprehension of biological processes at the nanoscale level. \n\n\n\nHost: Fangyuan Ding  \n\n\n\nSeminar will be held in person only. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-yongdeng-zhang/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250206T110000
DTEND;TZID=America/Los_Angeles:20250206T120000
DTSTAMP:20260826T212248Z
CREATED:20260826T212248Z
LAST-MODIFIED:20260826T212248Z
UID:50690-1738839600-1738843200@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Soledad Reyes de Barboza
DESCRIPTION:Dr. Soledad Reyes de Barboza\n\n\n\nAssistant Professor\, Cell and Developmental BiologyUniversity of California\, San Diego\n\n\n\n\n\n\n\n“The Good\, The Bad\, and The Ugly of Cellular Senescence: Implications for Lung Injury and Aging”\n\n\n\nAbstract: Cellular senescence is defined as an acquired state cells enter in response to environmental stressors or as a mechanism of tumor evasion. Senescent cells lose their proliferative capacity but enhance their ability to regulate and respond to the surrounding microenvironment through the senescence-associated secretory phenotype (SASP). A key feature of cellular senescence is the upregulation of the cyclin inhibitor p16INK4a. With age there is accumulation of senescent cells in tissues\, accompanied by increased p16INK4a expression. Although removal of p16INK4a expressing cells using genetic mouse models slows down aging\, it also impairs wound healing\, highlighting the complex and contradictory roles of p16INK4a during homeostasis\, regeneration\, and aging. Despite growing evidence of the dynamic\, and pleiotropic nature of the SASP\, our understanding of how it alters tissue microenvironments\, contributes to injury-specific responses\, and can be manipulated for therapeutic benefit in remains limited. To address this gap\, our research investigates the behaviors and consequences of secreted proteins by senescent cells in vivo\, with a particular focus on p16INK4a-expressing fibroblasts in the context of acute lung injuries. In this talk\, I will present preliminary data on how p16INK4a expressing fibroblasts respond to both acute alveolar lung injury and Influenza A virus (IAV) infection. By exploring the unique roles these senescent fibroblasts play in modulating tissue repair and immune responses\, we aim to uncover new insights into how the aging lung navigates injury and infection. These findings could not only reshape our understanding of aging and tissue regeneration but also provide a foundation for developing novel therapeutic strategies to combat viral infections\, particularly in aging populations who are more vulnerable to such diseases. \n\n\n\nHost: Ken Cho \n\n\n\nSeminar will be held in person only.  \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-soledad-reyes-de-barboza/
LOCATION:Natural Sciences II\, Room 4201
CATEGORIES:Events
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250130T110000
DTEND;TZID=America/Los_Angeles:20250130T120000
DTSTAMP:20260826T212321Z
CREATED:20260826T212321Z
LAST-MODIFIED:20260826T212321Z
UID:50673-1738234800-1738238400@www.bio.uci.edu
SUMMARY:Developmental and Cell Biology Seminar Series: Dr. Frank van Breukelen
DESCRIPTION:Dr. Frank van Breukelen\n\n\n\n          Director and Professor\, School of Life Sciences        University of Nevada\n\n\n\n\n\n\n\n“Being too plastic for variable environments: physiological plasticity in the protoendothermic tenrec (Tenrec ecaudatus)”\n\n\n\nAbstract: We typically think that plasticity confers advantages for changing environments. But what happens when an animal is too plastic? Tenrecs are enigmatic placental mammals from Madagascar that have many ‘ancestral’ traits e.g. they possess a cloaca\, the smallest brain of any extant mammal\, no functional corpus callosum\, and a variety of other features more ancestral than even the reconstructed placental mammal ancestor\, Schrewdinger. We posited this animal might then give us insight into the physiology of an early placental mammal. Tenrecs have remarkable plasticity- they have as much as a 25 fold variation in resting oxygen consumption rates\, body temperatures may be as low as 12°C in fully ambulatory and active tenrecs and 28°C in hibernating tenrecs\, gestation may range from 40 to 90 d\, tenrecs may grow as much as 25% in a day and experience indeterminate growth\, and tenrecs are capable of superfetation. Much of this metabolic plasticity is accomplished through sequestration of blood to the spleen which may vary in size by 14-fold. The consequences of this variability is a pulsatile homeostasis at the organ and cellular level. ESI MS proteomics reveal that more than 50% of proteins change in abundance during torpor. This contrasts sharply to Boreoeutherian (‘modern’) mammals where hibernation arrests animals in a quasi-homeostatic state and there are few transcript or protein abundance changes. We hypothesized that poor homeostasis limited the success of mammals like tenrecs and that Boreoeutherian mammals were so successful because of an ability to maintain a high and stable metabolism that supported a more consistent homeostatic state.  \n\n\n\nHost: Max Plikus \n\n\n\nSeminar will be held in person only. \n\n\n\nDevelopmental & Cell Biology Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-frank-van-breukelen/
LOCATION:California
CATEGORIES:Events
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/01/Dr-Frank-Van-Breukelen.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250123T110000
DTEND;TZID=America/Los_Angeles:20250123T120000
DTSTAMP:20260826T212320Z
CREATED:20260826T212320Z
LAST-MODIFIED:20260826T212320Z
UID:50668-1737630000-1737633600@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Yasuhiro Arimura
DESCRIPTION:Dr. Yasuhiro Arimura \n\n\n\nAssistant Professor\, Basic Sciences DivisionFred Hutchinson Cancer Center\n\n\n\n\n\n\n\n“Toward Sub-Nanometer Visualization of Endogenous Chromatin-Associated Complexes in Action”\n\n\n\nAbstract: Eukaryotic chromatin dynamically changes its structure during the cell cycle and cellular differentiation. The structures of these chromatin and chromatin-related complexes are considered instrumental in regulating numerous biological events on chromosomes. Nevertheless\, we have yet to visualize these structures at sub-nanometer resolution and thus are far from understanding the structural basis of these events. To address this\, I have been developing cryo-EM-based methods to analyze sub-nanometer-resolution chromatin structures formed in cellular environments. One method involves isolating the intact chromosome-associated complexes\, suitable for cryo-EM analysis\, from the interphase and metaphase chromosomes in Xenopus egg extract (Arimura Mol Cell\, 2021). However\, with this method\, although mass spectrometry detected approximately 1000 proteins in the samples prepared for the structural analysis\, the cryo-EM structures of these nucleosome-bound proteins\, except for the most abundant H1.8 and nucleosome could not be detected. To overcome this limitation\, Magnetic Isolation and Concentration (MagIC)-cryo-EM\, a technique enabling the direct structural analysis of targets captured on nanomagnetic beads (Arimura elife\, 2024) was developed. MagIC-cryo-EM\, which enables the isolation and cryo-EM structural determination of < 0.0005 mg/ml target protein complexes in heterogeneous samples\, was able to characterize the structural variations of nucleosomes associated with the oocyte-specific linker histone H1.8\, that were isolated from interphase and metaphase chromosomes in Xenopus egg extract. These two methods successfully provided structural insights into how the association of H1.8 with nucleosomes is regulated in a cell cycle-dependent manner. I believe that this method is highly beneficial for the chromatin biology field as it enables the sub-nanometer resolution structural analyses of native chromatin-related complexes. The required sample for MagIC-cryo-EM is heterogeneous liquid that contains the target molecules at a < 0.0005 mg/ml concentration\, which is 100 to 1000-fold lower than conventional cryo-EM methods. The sample amount required (~2 ng of DNA) is comparable to\, or even less than\, what is typically used in the widely adopted ChIP-seq method\, suggesting that numerous chromatin-related complexes that have been analyzed by ChIP-seq might be ideal targets for MagIC-cryo-EM. My newly established lab will further advance these methods to elucidate the structural basis of chromosomal events by enabling the sub-nanometer visualization of endogenous chromatin-associated complexes in action. \n\n\n\n \n\n\n\n \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-yasuhiro-arimura/
LOCATION:California
CATEGORIES:Events
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/01/Dr-Yasuhiro-Arimura.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250116T110000
DTEND;TZID=America/Los_Angeles:20250116T120000
DTSTAMP:20260826T212320Z
CREATED:20260826T212320Z
LAST-MODIFIED:20260826T212320Z
UID:50661-1737025200-1737028800@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Elphege Nora
DESCRIPTION:Dr. Elphege Nora \n\n\n\nAssistant ProfessorUniversity of California\, San Francisco\n\n\n\n\n\n\n\n“Molecular Mechanisms of Chromosome Folding and Enhancer Wiring”\n\n\n\nAbstract: I will discuss how cohesin proteins tune chromosomes folding patterns inside cells and how this enables long-range regulation by transcriptional enhancers in pluripotency and during cell differentiation.  \n\n\n\nHosts: Evgeny Kvon\, Arthur Lander\, Anne Calof \n\n\n\nSeminar will be held in person only. \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-elphege-nora/
LOCATION:California
CATEGORIES:Events
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/01/Dr-Elphege-Nora.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20250109T110000
DTEND;TZID=America/Los_Angeles:20250109T120000
DTSTAMP:20260826T212320Z
CREATED:20260826T212320Z
LAST-MODIFIED:20260826T212320Z
UID:50627-1736420400-1736424000@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Raul E. Diaz Jr
DESCRIPTION:Dr. Raul E. Diaz\, Jr. \n\n\n\nAssistant Professor of Biological SciencesCalifornia State University\, Los AngelesResearch Associate\, Natural History Museum of Los Angeles County\n\n\n\n\n\n\n\n“Resolving a paradox: how does vertebrate skull diversity arise when embryonic development is highly conserved?”\n\n\n\nAbstract: The vertebrate cranium is arguably the most architecturally complex part of the body and receives cellular contributions from all embryonic germ layers. The outer-most skeletal layer\, the dermatocranium\, which forms the flat bones of the skull\, has been studied extensively for both extinct and extant lineages. Such broad comparative studies have\, over the past century\, supported the idea that lineage specific dermatocranial morphologies arise primarily from the differential loss of skull bones which has led to a more ‘simplified’ skull relative to ancestral tetrapods that present a greater number of distinct bones in the skull of adults (i.e\, Williston’s Law). Herein I present the first systematic examination of the formation\, fusion\, and loss of dermatocranial skeletal elements across all major lineages of extant vertebrates using a phylogenetically comprehensive and ontogenetically rich series of embryos and adults. \n\n\n\nHost: Max Plikus \n\n\n\nSeminar will be held in person only.  \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-raul-e-diaz-jr-2/
LOCATION:California
CATEGORIES:Events
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2025/01/Dr-Raul-Diaz-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241205T110000
DTEND;TZID=America/Los_Angeles:20241205T120000
DTSTAMP:20260828T164253Z
CREATED:20260828T164253Z
LAST-MODIFIED:20260828T164253Z
UID:50108-1733396400-1733400000@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Rémi Buisson
DESCRIPTION:Dr. Rémi Buisson\n\n\n\nAssociate Professor\, Department of Biological ChemistryUniversity of California\, Irvine\n\n\n\n\n\n\n\n\n\n\n\n“APOBEC3A and APOBEC3B: Mutagenic Fuel for Cancer Evolution”\n\n\n\n\n\n\n\nAbstract: The Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) proteins promote the deamination of cytosine to uracil in DNA or RNA. APOBEC enzymes serve as essential components of the immune system\, acting as defense mechanisms against DNA or RNA viruses and transposons by inducing mutations. However\, APOBEC proteins are also one of the predominant causes of genomic mutations in cancer. Indeed\, cancer-focused genomic studies have identified APOBEC3A and APOBEC3B-associated mutations in >70% of cancer types. Herein\, we will reveal the mechanism by which APOBEC3A and APOBEC3B generate mutation in cancer genomes. \n\n\n\nFor more info about Dr. Buisson’s work: https://buissonlab.com \n\n\n\n \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-remi-buisson/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, California\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2024/10/Dr.-Remi-Buisson.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241121T110000
DTEND;TZID=America/Los_Angeles:20241121T120000
DTSTAMP:20260828T164252Z
CREATED:20260828T164252Z
LAST-MODIFIED:20260828T164252Z
UID:50105-1732186800-1732190400@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Stavros Lomvardas
DESCRIPTION:Dr. Stavros Lomvardas\n\n\n\nRoy and Diana Vagelos Professor and ChairBiochemistry and Molecular BiophysicsColumbia University\n\n\n\n\n\n\n\n\n\n\n\n“DNA-induced allostery as a solution for the genome specificity paradox”\n\n\n\n\n\n\n\nAbstract: Tissue specific gene activation often requires assembly of long range genomic interactions between promoters and intergenic enhancers. An extreme version of these ultra long-range interactions is found in the olfactory system\, whereby enhancers from multiple chromosomes assemble multi-enhancer hubs that activate one out of ~1000 olfactory receptor genes in a monoallelic fashion. These highly specific genomic interactions are orchestrated by transcription factor Lhx2 and architectural protein Ldb1\, which are also bound in thousand of other sites in the genome\, creating the paradox of genome interaction specificity without transcription factor binding exclusivity. Our biochemical and imaging experiments suggest the sequence of the interacting DNA elements may induce sequence-specific allosteric changes to Lhx2/Ldb1 complexes that account for this remarkable specificity. \n\n\n\nFor more info about Dr. Lomvardas’s work: https://lomvardaslab.zuckermaninstitute.columbia.edu \n\n\n\n \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-stavros-lomvardas/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, California\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2024/10/Dr.-Stavros-Lomvardas.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241120T160000
DTEND;TZID=America/Los_Angeles:20241120T160000
DTSTAMP:20260826T212326Z
CREATED:20260826T212326Z
LAST-MODIFIED:20260826T212326Z
UID:50134-1732118400-1732118400@www.bio.uci.edu
SUMMARY:May the Fiber Be with You: Cultivating a Healthy Microbiome
DESCRIPTION:May the Fiber Be with You: Cultivating a Healthy Microbiome\, is the first lecture of the Mind\, Body\, World & You lecture series. \n\n\n\nLearn how fiber-rich diets influence your gut microbiome — something that affects not only your digestion but your overall health and well-being. You’ll learn which dietary choices can promote microbial diversity and why that matters for everything from immunity to mental health. \n\n\n\nWhy attend? \n\n\n\n\nGet inspired by innovative research happening right here at the Dunlop School.\n\n\n\nConnect with faculty and classmates who share your interests\, and network with people who might be involved in the kinds of projects or labs you want to join.\n\n\n\nBoost your knowledge in an area that’s not only scientifically fascinating but also relevant to your daily life.\n\n\n\n\nFiber-rich foods will be served after the talk\, so don’t miss this chance to learn\, connect and engage with your community! \n\n\n\nEvent Details: \n\n\n\nLecture: 4 to 5 p.m. \n\n\n\nFood & Networking: 5 to 6 p.m. \n\n\n\nWhere: Student Center\, Crystal Cove Auditorium \n\n\n\n\n\nIf you have questions about this event\, please email biosci-events@uci.edu.
URL:https://www.bio.uci.edu/event/may-the-fiber-be-with-you/
LOCATION:UCI Student Center\, Pacific Ballroom D\, 311 W Peltason Dr.\, Irvine\, CA\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2024/10/Mind-Body-World-and-You-1000-x-700-px.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241114T110000
DTEND;TZID=America/Los_Angeles:20241114T120000
DTSTAMP:20260826T212326Z
CREATED:20260826T212326Z
LAST-MODIFIED:20260826T212326Z
UID:50099-1731582000-1731585600@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Yixian Zheng
DESCRIPTION:Dr. Yixian Zheng\n\n\n\nInvestigator\, Carnegie Institution for Science\n\n\n\n\n\n\n\n\n\n\n\n“Cell and developmental biology in different contexts”\n\n\n\n\n\n\n\nAbstract: We use a wide range of tools and model organisms in our research. Guided by our interest in the cell biology underpinning of organism development and function\, we aim to understand how microtubules contribute to cell division\, how lamins facilitate genome organization during development\, and how animals develop the endosymbiotic lifestyle with algae. I will summarize our past findings and highlight our unpublished studies in each of the three areas. \n\n\n\nFor more info about Dr. Zheng’s work: https://yixianzhenglab.com \n\n\n\n \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-yixian-zheng/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, California\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2024/10/Dr.-Yixian-Zheng.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241107T110000
DTEND;TZID=America/Los_Angeles:20241107T120000
DTSTAMP:20260826T212326Z
CREATED:20260826T212326Z
LAST-MODIFIED:20260826T212326Z
UID:50096-1730977200-1730980800@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Samantha Butler
DESCRIPTION:Dr. Samantha J. Butler\n\n\n\nProfessor and Vice Chair for Equity\, Diversity and Inclusion\,Department of Neurobiology David Geffen School of Medicine\,University of California\, Los Angeles\n\n\n\n\n\n\n\n\n\n\n\n“Revisiting the role(s) of netrin1 in the establishment of spinal cord circuitry”\n\n\n\n\n\n\n\nAbstract: We have identified an unexpected role for netrin1 as a suppressor of bone morphogenetic protein (Bmp) signaling in the developing dorsal spinal cord. Using a combination of gain- and loss-of-function approaches in chicken\, embryonic stem cell (ESC)\, and mouse models\, we have observed that manipulating the level of netrin1 specifically alters the patterning of the Bmp-dependent dorsal interneurons (dIs)\, dI1-dI3. Altered netrin1 levels also change Bmp signaling activity\, as measured by bioinformatics\, and monitoring phosophoSmad1/5/8 activation\, the canonical intermediate of Bmp signaling\, and Id levels\, a known Bmp target. Together\, these studies support the hypothesis that netrin1 acts from the intermediate spinal cord to regionally confine Bmp signaling to the dorsal spinal cord. Thus\, netrin1 has reiterative activities shaping dorsal spinal circuits\, first by regulating cell fate decisions and then acting as a short range guidance cue to direct axon extension. \n\n\n\nFor more info about Dr. Butler’s work: https://stemcell.ucla.edu/member-directory/samantha-j-butler-phd \n\n\n\n \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-samantha-butler/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, California\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2024/10/Dr.-Samantha-J.-Butler.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241107T110000
DTEND;TZID=America/Los_Angeles:20241107T120000
DTSTAMP:20260826T212325Z
CREATED:20260826T212325Z
LAST-MODIFIED:20260826T212325Z
UID:50632-1730977200-1730980800@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Samantha Butler
DESCRIPTION:Dr. Samantha J. Butler\n\n\n\nProfessor and Vice Chair for Equity\, Diversity and Inclusion\,Department of Neurobiology David Geffen School of Medicine\,University of California\, Los Angeles\n\n\n\n\n\n\n\n\n\n\n\n“Revisiting the role(s) of netrin1 in the establishment of spinal cord circuitry”\n\n\n\n\n\n\n\nAbstract: We have identified an unexpected role for netrin1 as a suppressor of bone morphogenetic protein (Bmp) signaling in the developing dorsal spinal cord. Using a combination of gain- and loss-of-function approaches in chicken\, embryonic stem cell (ESC)\, and mouse models\, we have observed that manipulating the level of netrin1 specifically alters the patterning of the Bmp-dependent dorsal interneurons (dIs)\, dI1-dI3. Altered netrin1 levels also change Bmp signaling activity\, as measured by bioinformatics\, and monitoring phosophoSmad1/5/8 activation\, the canonical intermediate of Bmp signaling\, and Id levels\, a known Bmp target. Together\, these studies support the hypothesis that netrin1 acts from the intermediate spinal cord to regionally confine Bmp signaling to the dorsal spinal cord. Thus\, netrin1 has reiterative activities shaping dorsal spinal circuits\, first by regulating cell fate decisions and then acting as a short range guidance cue to direct axon extension. \n\n\n\nFor more info about Dr. Butler’s work: https://stemcell.ucla.edu/member-directory/samantha-j-butler-phd \n\n\n\n \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-samantha-butler-2/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, California\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2024/10/Dr.-Samantha-J.-Butler.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241031T110000
DTEND;TZID=America/Los_Angeles:20241031T120000
DTSTAMP:20260828T164251Z
CREATED:20260828T164251Z
LAST-MODIFIED:20260828T164251Z
UID:50093-1730372400-1730376000@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Star Lee
DESCRIPTION:Dr. Star Lee\n\n\n\nAssistant Professor of Teaching\, Department of Developmental Cell BiologyUniversity of California\, Irvine\n\n\n\n\n\n\n\n\n\n\n\n“Evidence for inclusive strategies in the classroom and research lab”\n\n\n\n\n\n\n\nAbstract: Coming Soon \n\n\n\nFor more info about Dr. Lee’s work: https://devcell.bio.uci.edu/faculty/star-lee/ \n\n\n\n \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-star-lee/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, California\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2024/10/Dr.-Star-Lee.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241024T160000
DTEND;TZID=America/Los_Angeles:20241024T170000
DTSTAMP:20260828T164255Z
CREATED:20260828T164255Z
LAST-MODIFIED:20260828T164255Z
UID:50006-1729785600-1729789200@www.bio.uci.edu
SUMMARY:Donuts with the Dean: Fall 2024
DESCRIPTION:Join us for the return of Dunlop BioSci’s quarterly Donuts with the Dean!\n\n\n\nPlease join us on Thursday\, October 24 from 4 – 5 p.m. on the 5th Floor of Natural Sciences II. \n\n\n\nJoin Dean Frank LaFerla and hear from our guest speaker\, Dr. Jay Calvert. Afterwards\, enjoy a donut and fruit\, while talking to Dunlop School faculty\, students and our speaker \n\n\n\nAbout the Speaker:\n\n\n\n\n\n\n\nDr. Jay Calvert is a Board Certified Plastic Surgeon with practices in Beverly Hills and Newport Beach\, California. He performs all types of plastic surgery\, but he focuses on rhinoplasty\, revision rhinoplasty\, deep plane facelifts\, fox eye surgery\, facelifts\, and breast augmentation surgery in both Beverly Hills and Newport Beach. Dr. Jay Calvert has published many articles about rhinoplasty and secondary rhinoplasty and pioneered many new techniques that have helped his patients get the best results possible. \n\n\n\nThis event is full. \n\n\n\nThis event is currently full\, but please check out our Dean’s Distinguished Lecture on October 23 to network with faculty\, students\, and the Dunlop BioSci community while learning more about Dr. Al La Spada’s research. \n\n\n\nSign up for the Dean’s Distinguished Lecture here.
URL:https://www.bio.uci.edu/event/donuts-with-the-dean-fall-2024/
LOCATION:Natural Sciences II\, 5th Floor Lobby\, 5120 Natural Sciences II\, Irvine\, California\, 92697
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2024/10/Website-Featured-Image-1000-x-700-px.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241024T110000
DTEND;TZID=America/Los_Angeles:20241024T120000
DTSTAMP:20260828T164252Z
CREATED:20260828T164252Z
LAST-MODIFIED:20260828T164252Z
UID:50002-1729767600-1729771200@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Dae Seok Eom
DESCRIPTION:Dr. Dae Seok Eom\n\n\n\nAssistant Professor\, Department of Developmental Cell BiologyUniversity of California\, Irvine\n\n\n\n\n\n\n\n\n\n\n\n“Airineme-mediated intercellular communication in zebrafish skin”\n\n\n\n\n\n\n\nAbstract: Cell-to-cell signaling is a fundamental process in living organisms\, and its misregulation can lead to various diseases and cancers. Consequently\, understanding its underlying mechanisms has been a central topic in biology and medicine for decades. Recent advancements have identified previously unappreciated signaling modalities\, one of which is airinemes. Airinemes are long cellular protrusions that extend and target pigment cells\, playing a critical role in pigment pattern development in zebrafish. They deliver Delta ligands from yellow pigment cells to dark melanophores\, where they activate Notch signaling in a target-specific manner. Interestingly\, skin-resident macrophages are essential for airineme signaling. The complex interplay between airineme-extending and airineme-receiving cells\, as well as macrophages\, is a unique feature of this signaling mechanism. \n\n\n\nSince establishing my lab at UCI in 2018\, current and former lab members have focused on elucidating the underlying cellular and molecular mechanisms of airineme-mediated signaling and other signaling cellular protrusions. In this talk\, I will present the discoveries we have made over the past six years and outline future directions for our research. \n\n\n\nFor more info on Dr. Eom’s work: https://eomlaboratory.com \n\n\n\n \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-dae-seok-eom/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, California\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://www.bio.uci.edu/wp-content/uploads/2024/10/Dae-Seok-Eom.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241023T160000
DTEND;TZID=America/Los_Angeles:20241023T180000
DTSTAMP:20260826T212319Z
CREATED:20260826T212319Z
LAST-MODIFIED:20260826T212319Z
UID:49873-1729699200-1729706400@www.bio.uci.edu
SUMMARY:Dean's Distinguished Lecture - Fall 2024
DESCRIPTION:Please arrive 15 minutes prior to the event for registration. Lecture from 4 to 5 p.mLight refreshments and beverages will be available during the reception from 5 to 6 p.m.  \n\n\n\n\n\n\n\nDefining the Mechanistic Basis of Neurodegenerative Proteinopathy:A 35 Year Genetic Odyssey\n\n\n\nJoin us for a talk with Distinguished Professor Albert La Spada\, M.D.\, Ph.D.\n\n\n\n\n\n\n\nYou are invited to the Charlie Dunlop School of Biological Sciences’ Dean’s Distinguished Lecture Series\, featuring Distinguished Professor Albert La Spada\, M.D.\, Ph.D.\, on October 23\, 2024\, in the Crystal Cove Auditorium at the UCI Student Center. \n\n\n\nEvent Details: \n\n\n\nTalk and Q&A: 4 to 5 p.m. \n\n\n\nReception: 5 to 6 p.m. \n\n\n\n\n\n\n\n\n\n\n\nRegister to Attend the Dean’s Distinguished Lecture\n\n\n\n\n\n\n\n\n\nAbout Distinguished Professor La Spada\n\n\n\nDistinguished Professor La Spada is a renowned researcher whose work focuses on understanding and treating neurodegenerative diseases such as Alzheimer’s\, Parkinson’s and ALS. His lab is working to uncover what causes nerve cells to break down and die\, using cutting-edge research to develop potential therapies for these devastating disorders. \n\n\n\nLearn more about the La Spada lab here. \n\n\n\nIf you have questions about this event\, please email biosci-events@uci.edu.
URL:https://www.bio.uci.edu/event/deans-distinguished-lecture-fall-2024/
LOCATION:Crystal Cove Auditorium – UCI Student Center\, 4113 Pereira Dr.\, Irvine\, California\, 92697\, United States
CATEGORIES:Dean's Distinguished Lecture
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241017T110000
DTEND;TZID=America/Los_Angeles:20241017T120000
DTSTAMP:20260828T164253Z
CREATED:20260828T164253Z
LAST-MODIFIED:20260828T164253Z
UID:49996-1729162800-1729166400@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Dr. Xiaoyu Shi
DESCRIPTION:Dr. Xiaoyu Shi\n\n\n\nAssistant Professor\, Department of Developmental Cell BiologyUniversity of California\, Irvine\n\n\n\n\n\n\n\n“Super-Resolution Microscopy and Spatial Omics Uncover New Functions Of Nuclear Deformation”\n\n\n\n \n\n\n\n\nAbstract: This seminar features Dr. Shi’s tenure research presentation\, focusing on her lab’s contributions to innovative biotechnologies and the exploration of cellular mechanisms related to aging and cancer. She will provide an overview of her research program and recent breakthroughs\, particularly discussing Label-Retention Expansion Microscopy (LR-ExM)\, which achieves an impressive resolution of up to 5 nm for imaging cells and tissues\, and Gel-based Optical-Isolation 3D (GO3D) Spatial Multimomics\, which enables unbiased analysis of proteome and transcriptome with subcellular 3D spatial resolution. These technologies can potentially transform our understanding of the molecular mechanisms underlying aging\, cancer\, and neurological disorders. Dr. Shi will conclude her talk by showcasing a cellular mechanism identified using LR-ExM\, highlighting nuclear invagination as a key regulator of ribosome biogenesis. This new mechanism is shared between aging and cancer cells. \n\n\n\nFor more info bout Dr. Shi’s work: https://www.shilab.bio.uci.edu \n\n\n\n\n\n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-dr-xiaoyu-shi/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, California\, 92697\, United States
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241010T110000
DTEND;TZID=America/Los_Angeles:20241010T120000
DTSTAMP:20260828T164254Z
CREATED:20260828T164254Z
LAST-MODIFIED:20260828T164254Z
UID:49985-1728558000-1728561600@www.bio.uci.edu
SUMMARY:DCB Seminar Series: Ryan Weiss
DESCRIPTION:Dr. Ryan J. Weiss\n\n\n\nAssistant Professor\, Department of Biochemistry and Molecular Biology\n\n\n\nComplex Carbohydrate Research Center at the University of Georgia\n\n\n\n\n\n\n\n\n\n\n\n“Targeting Heparan Sulfate Biosynthesis in Rare Disease”\n\n\n\n\n\n\n\nAbstract: The Weiss Laboratory at the UGA Complex Carbohydrate Research Center studies the structure\, function\, and regulation of complex carbohydrates in human health and disease. Specifically\, my group utilizes cellular\, genomic\, and biochemical approaches to investigate the molecular mechanisms controlling the biosynthesis of key cellular polysaccharides\, known as heparan sulfate (HS)\, which are ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These sulfated polysaccharides regulate many important biological processes including cell proliferation and development through their interaction with a large number of matrix proteins and growth factors. Dysregulation of HS assembly and catabolism has been implicated in human diseases\, including cancer and rare genetic disorders. Due to the key roles of HS in cell homeostasis and disease\, there is much interest in targeting the assembly and function of HS as a therapeutic approach.  Our lab utilizes high throughput drug screening and CRISPR screening approaches to identify novel therapeutic agents and drug targets to tune HS assembly. We are currently focused on drug discovery for two rare genetic disorders\, the congenital skeletal disorder Multiple Hereditary Exostoses (MHE) and the lysosomal storage disorder\, Sanfilippo Syndrome (MPS III). Drug candidates are currently being investigated in patient-derived cellular and in vivo models for these rare disorders. Overall\, these studies provide new insights into the molecular mechanisms by which HS biogenesis is differentially regulated in cells and will identify therapeutic agents and targets to modulate HS assembly for disorders of glycosylation. \n\n\n\n \n\n\n\nDevelopmental & Cell Biology Fall 2024 Seminar Series \n\n\n\nEach quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m.\, in Natural Sciences II room 4201. \n\n\n\nFor questions about this event\, please contact Mayra Rubio at mrubio3@uci.edu.
URL:https://www.bio.uci.edu/event/dcb-seminar-series-ryan-weiss/
LOCATION:4201 Natural Sciences II\, 4201 Natural Sciences II\, Irvine\, California\, 92697\, United States
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240924T093000
DTEND;TZID=America/Los_Angeles:20240924T153000
DTSTAMP:20260828T164255Z
CREATED:20260828T164255Z
LAST-MODIFIED:20260828T164255Z
UID:49604-1727170200-1727191800@www.bio.uci.edu
SUMMARY:2024 MSP Research Symposium: Day Two
DESCRIPTION:Date: September 24\, 2024Time: 9:30 a.m. – 3:30 p.m. \n\n\n\nEach year\, undergraduate and graduate students participating in MSP research come together to present their findings at a two-day symposium at Dunlop School.  \n\n\n\nView agenda here. \n\n\n\nFor more information\, please contact: \n\n\n\nDr. Marlene de la Cruz9498242589marlene@uci.edu
URL:https://www.bio.uci.edu/event/2024-msp-research-symposium-day-two/
LOCATION:California
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240923T093000
DTEND;TZID=America/Los_Angeles:20240923T153000
DTSTAMP:20260826T212251Z
CREATED:20260826T212251Z
LAST-MODIFIED:20260826T212251Z
UID:49611-1727083800-1727105400@www.bio.uci.edu
SUMMARY:2024 MSP Research Symposium: Day One
DESCRIPTION:Date: September 23\, 2024Time: 9:30 a.m. – 3:30 p.m. \n\n\n\nEach year\, undergraduate and graduate students participating in MSP research come together to present their findings at a two-day symposium at Dunlop School.  \n\n\n\nView agenda here. \n\n\n\nFor more information\, please contact: \n\n\n\nDr. Marlene de la Cruz9498242589marlene@uci.edu
URL:https://www.bio.uci.edu/event/2024-msp-research-symposium-day-one/
LOCATION:California
CATEGORIES:Events
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240606T150000
DTEND;TZID=America/Los_Angeles:20240606T160000
DTSTAMP:20260828T164150Z
CREATED:20260828T164150Z
LAST-MODIFIED:20260828T164150Z
UID:44731-1717686000-1717689600@www.bio.uci.edu
SUMMARY:Adam Martiny\, Earth System Science – Thursday\, June 6
DESCRIPTION:Join us for our monthly microbiome series! \n\n\n\nWe are happy to announce the return of Monthly Microbiome Meetings with a series highlighting UCI faculty. The seminars are open to the UCI community and beyond and take place on the first Thursday of each month\, 3-4pm in Natural Sciences I\, room 1114. Refreshments will be served. \n\n\n\nThe topic of this event is TBD.
URL:https://www.bio.uci.edu/event/adam-martiny-earth-system-science-thursday-june-6/
LOCATION:Natural Sciences 1\, room 1114\, Irvine\, CA\, United States
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240502T150000
DTEND;TZID=America/Los_Angeles:20240502T160000
DTSTAMP:20260828T163759Z
CREATED:20260828T163759Z
LAST-MODIFIED:20260828T163759Z
UID:44725-1714662000-1714665600@www.bio.uci.edu
SUMMARY:Saurabh Chatterjee\, Environmental and Occupational Health – Thursday\, May 2
DESCRIPTION:Join us for our monthly microbiome series! \n\n\n\nWe are happy to announce the return of Monthly Microbiome Meetings with a series highlighting UCI faculty. The seminars are open to the UCI community and beyond and take place on the first Thursday of each month\, 3-4pm in Natural Sciences I\, room 1114. Refreshments will be served. \n\n\n\nThe topic of this event is TBD.
URL:https://www.bio.uci.edu/event/saurabh-chatterjee-environmental-and-occupational-health-thursday-may-2/
LOCATION:Natural Sciences I
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END:VCALENDAR