October 24 @ 11:00 AM – 12:00 PM
Dr. Dae Seok Eom
Assistant Professor, Department of Developmental Cell Biology
University of California, Irvine
“Airineme-mediated intercellular communication in zebrafish skin”
Abstract: Cell-to-cell signaling is a fundamental process in living organisms, and its misregulation can lead to various diseases and cancers. Consequently, understanding its underlying mechanisms has been a central topic in biology and medicine for decades. Recent advancements have identified previously unappreciated signaling modalities, one of which is airinemes. Airinemes are long cellular protrusions that extend and target pigment cells, playing a critical role in pigment pattern development in zebrafish. They deliver Delta ligands from yellow pigment cells to dark melanophores, where they activate Notch signaling in a target-specific manner. Interestingly, skin-resident macrophages are essential for airineme signaling. The complex interplay between airineme-extending and airineme-receiving cells, as well as macrophages, is a unique feature of this signaling mechanism.
Since establishing my lab at UCI in 2018, current and former lab members have focused on elucidating the underlying cellular and molecular mechanisms of airineme-mediated signaling and other signaling cellular protrusions. In this talk, I will present the discoveries we have made over the past six years and outline future directions for our research.
For more info on Dr. Eom’s work: https://eomlaboratory.com
Developmental & Cell Biology Fall 2024 Seminar Series
Each quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m., in Natural Sciences II room 4201.
For questions about this event, please contact Mayra Rubio at mrubio3@uci.edu.