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Fall 2023 Seminar Series
Each quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m., in Natural Sciences II room 4201, and live streamed via Zoom. For seminar schedule click here.
Dr. Doina Tumbar
Professor, Molecular Biology and Genetics
Cornell University
“Epithelial skin stem cells in action: cell intrinsic and niche related mechanisms“
Abstract:
We are studying basic cellular and molecular mechanisms that regulate tissue stem cell activity, focusing on adult epithelial stem cells in the skin. Using genetic and genomic approaches in mouse skin and comparing with human skin, we are mapping the organization and regulation of hair follicle and epidermal stem cells and their interaction with the microenvironment or ‘niche’. We are analyzing genetic control of stem cell activation, self-renewal, and differentiation. Our general focus is on stem cell fate choice by epigenetic regulation, transcription regulation via specific developmental transcription factors and RNA Pol II Pausing mechanisms, and chromatin modifying factors. We are particularly fascinated by the role of epithelial stem cells in organizing cells in their surrounding environment, such as melanocytes, blood vessels, nerves, fat cells, and fibroblast. Additionally, we explore how our findings in mice might apply to normal and diseased human skin.
We are studying basic cellular and molecular mechanisms that regulate tissue stem cell activity, focusing on adult epithelial stem cells in the skin. Using genetic and genomic approaches in mouse skin and comparing with human skin, we are mapping the organization and regulation of hair follicle and epidermal stem cells and their interaction with the microenvironment or ‘niche’. We are analyzing genetic control of stem cell activation, self-renewal, and differentiation. Our general focus is on stem cell fate choice by epigenetic regulation, transcription regulation via specific developmental transcription factors and RNA Pol II Pausing mechanisms, and chromatin modifying factors. We are particularly fascinated by the role of epithelial stem cells in organizing cells in their surrounding environment, such as melanocytes, blood vessels, nerves, fat cells, and fibroblast. Additionally, we explore how our findings in mice might apply to normal and diseased human skin.