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Fall 2023 Seminar Series
Each quarter the Department of Developmental and Cell Biology hosts a weekly seminar. The purpose of these seminars is to enable experts from around the country to share their newest discoveries and ideas with our students and faculty. Seminars are held on Thursdays at 11:00 a.m., in Natural Sciences II room 4201, and live streamed via Zoom. For seminar schedule click here.
Dr. James F. Martin
Professor, Baylor College of Medicine & Texas Heart Institute
Hippo-signaling in Heart Regeneration
Abstract:
The mammalian heart regenerates poorly and damage commonly leads to heart failure. The Hippo pathway is an evolutionarily conserved kinase cascade that regulates heart size during development and prevents adult mammalian cardiomyocyte regeneration by inhibiting the transcription cofactor Yap. Recent work indicates that deletion of the Hippo pathway component, Salv, in cardiomyocytes can reverse ischemic heart failure in a mouse model. Further experiments have uncovered Yap target genes and provided insight into the mechanisms by which Yap regulated cardiomyocyte gene expression.