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DCB Seminar Series Featuring Dr. Julie Biteen, from the University of Michigan

December 7, 2023 @ 11:00 AM 12:00 PM

“Determining the nature of interactions and biomolecular condensates in microbes”


Single-molecule microscopy accesses nanometer-scale information with a benchtop microscope, providing a platform to super-resolve fluorescence emission, position, and dynamics, even in living cells. The Biteen Lab is developing new single-molecule methods to answer fundamental, unanswered questions in microbiology with applications including elucidating cell regulation and mis-regulation, understanding epigenetic inheritance, and visualizing nutrient utilization in the microbiome. These direct, quantitative, and high-resolution approaches have consequences in understanding subcellular biochemistry and biophysics. I will focus on our recently developed approaches to quantifying how cellular components interact and organize in microbiology. On one hand, we are evaluating the millisecond- and nanometer-scale dynamics of specific partners, and I will present as an example how HP1 proteins specifically and selectively associate with heterochromatin to silence gene expression in fission yeast. On the other hand, we are developing a generalizable, accessible, and rigorous framework to probe the nature of biomolecular condensates on the sub-micron scale in bacterial cells, and I will show how we probed the formation, reversibility, protein dynamics, and material state of biomolecular condensates in Escherichia coli to achieve a general model of bacterial cell organization.


Email: Mayra Rubio mrubio3@uci.edu


Date: December 7

Time: 11:00 am – 12:00 pm

Developmental and Cell Biology

4201 Natural Sciences II

4201 Natural Sciences II
Irvine, California 92697
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