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Subhojit Roy, MD, PhD
University of Wisconsin-Madison
Title: Neuronal Trafficking in Physiology and Disease
Date: Friday, December 14th, 2018
Location: Herklotz Conference Center, Center for Neurobiology of Learning and Memory
Abstract: Due to their complex geometry and finite sites of bulk protein synthesis (perikarya), neurons have evolved elaborate transport and trafficking machineries to deliver proteins into axons and dendrites. The Roy lab is interested in mechanisms delivering somatically-synthesized proteins to their appropriate sites in axons and synapses, particularly the transport of soluble cargoes that is not well understood. Trafficking routes are also relevant for neurodegenerative diseases – such as amyloid trafficking in Alzheimer’s disease – and the lab is keen to clarify these mechanisms in neurons. More recently, the lab has been involved in harnessing gene-editing to therapeutically manipulate trafficking pathways in Alzheimer’s and other diseases.