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Neurobiology and Behavior Seminar

Friday, April 19th, 2019

11 AM, Dale Melbourne Herklotz Conference Center, Center for Neurobiology of Learning and Memory (Building 506 on the campus map)

 

Majid Mohajerani, PhD

University of Lethbridge

 

Probing the spatiotemporal dynamics of hippocampal-cortical dialogue in health and Alzheimer’s disease

 

Abstract:

In my talk, I will provide new information regarding the interaction of hippocampus (HPC) and neocortex (NC) during sleep. Although evidence indicates that episodic memories are formed through a functional coupling between hippocampal and cortical network activity, how they interact to subserve a transfer of information is less clear. To provide new insight regarding the interaction of HPC and NC during sleep, we have combined novel imaging technologies with genetic, molecular and electrophysiological techniques to interrogate the cortical circuits at the level of individual synapses and function with millisecond temporal resolution across the entire cortex with information from the hippocampus. Further, I will discuss our effort to monitor how HPC output to NC is altered in the mouse model of Alzheimer’s disease.

Details

Date:
April 19
Time:
11:00 AM - 12:00 PM
Event Category:

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