Research Facilities
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Research Facilities

The UCI School of Biological Sciences research facilities include the following locations available for faculty use. Please contact each one directly for more information.

For additional research facilities, please check with the School of Physical Sciences facilities and School of Medicine facilities.

Bio Cluster

The School of Biological Sciences owns a High Performance Computing Cluster that includes a 700-core Opteron cluster with 400 Tb of disk space for use of the Biological Sciences faculty and students to supplement the computational pipelines of the Institute of Genomics and Bioinformatics, which handles primary read mapping. Faculty with additional needs can contribute new core nodes and storage space, which can be connected to the computer cluster via an infiniBand switch. The additional storage space is then dedicated specifically to the lab contributing and the queuing system gives first priority to access on the cores nodes you contributed with access to the additional hundreds of cores when idle.

Contact for Bio Cluster: Matthew Martinez, IT Director

Biomolecular Spectrometry Facility

The 800 MHz NMR spectrometer (1394 Natural Sciences I) can detect proton, carbon and nitrogen signals and is equipped with hardware optimized for biomolecular applications.  The Biacore 300 instrument (1304 Natural Sciences I) can measure docking interactions and binding affinity between biomolecules.

Location: 1218 Natural Sciences Building 1, Irvine, CA 92697
Contact for Biacore or NMR instruments:
Melanie Cocco, Associate Professor, Department of Molecular Biology and Biochemistry
Office: 949-824-4487

Isotope Ratio Mass Spectrometry Facility

The UC Irvine IRMS Facility in the School of Physical Sciences houses a variety of instrumentation to prepare and analyze gases, organic matter, inorganic samples, and water for stable isotope analysis. The five IRMS at UC Irvine measure stable isotope ratios of the light elements: Carbon, Nitrogen, Oxygen, and Hydrogen.

Location: Croul Hall in the Department of Earth System Science.
Dachun Zhang, IRMS Lab Manager, 949-824-6446
Kathleen Johnson, Assistant Professor, Department of Earth System Science

Laboratory for Electron and X-ray Instrumentation (LEXI)

LEXI is a university-wide shared user facility focusing on electron microscopy and X-ray analysis, and has several instruments applicable to biologist. The FEI Quanta 3D SEM is a state-of-the-art dual-beam SEM/FIB and may be operated under different vacuum modes, for example, high vacuum, low vacuum and environmental (ESEM). The Rigaku SmartLab X-ray Diffractometer and the Rigaku Ultima III X-ray Powder Diffractometer both have small-angle X-ray scattering (SAXS) capabilities for structural biology analysis.

Location: All three instruments are located in Calit2, Room 1302
Contact: Jian-Guo Zheng, Staff Director
Phone: 949-824-0441

Laboratory for Fluorescence Dynamics (LFD)

The Laboratory for Fluorescence Dynamics (LFD) occupies an approximately 8000 sq. ft. facility at the Biomedical Engineering Department in the interdisciplinary Natural Sciences II building of the University of California, Irvine. It maintains a state-of-the-art laboratory for fluorescence measurements with resources for spectroscopy, microscopy, biochemistry, cell culture, and data analysis.

Location: 3208 Natural Sciences II
Contact: Tracey Scott
Phone: 949-824-7085

Mass Spectrometry Facility, Department of Chemistry

The Mass Spectrometry Facility has multiple instruments applicable to biological applications. LC-ESI-MS (TOF and QqQ) and GC-MS are available in Open Access format for small molecule analysis, e.g., for identification and quantification of drugs and endogenous compounds. Protein analysis and identification is offered using nano-LC-MS/MS and MALDI-TOF (the latter also Open Access).

Location: Reines Hall 1002
Contact: Felix Grun, Ph.D., Staff Director
Phone: 949-824-3453

Optical Biology Core Facility

The Optical Biology Center (OBC) Shared Resource Facility provides researchers with access to state-of-the-art microscopes, training and and technical support.

Location: 4th floor of McGaugh Hall
Contact: Dr. J. Lawrence Marsh, director

Proteomics & Mass Spectrometry Facility

Contact: Professor Paul D. Gershon, Director
Phone: 949-824-9606 or 949-824-7954

Stem Cell Core Facility

The Stem Cell Core Facility,  a key component of the Sue and Bill Gross Stem Cell Research Center provides stem cell technology and resources to the UCI, Orange County and Southern California research communities. These include developmental and molecular genetics, cell culture and cell sorting, imaging, high-throughput platforms, and bioinformatics.

Contact:; 949-824-9621
Core Facility Research Coordinator: Christina Tu

Transgenic Mouse Facility

The Transgenic Mouse Facility (TMF) provides services on a recharge basis for making, breeding, genotyping, importing, and preserving genetically-modified mice and embryonic stem cells for UC Irvine investigators.

Manager Director and primary contact for all services:
Mr. Jon Neumann;

Scientific Director: Dr. Grant MacGregor;

UCI Genomics High-Throughput Facility

The mission of the UCI Genomics High-Throughput Facility (GHTF) is to provide genome-wide analysis for clients interested in gene expression, regulation of gene expression, and genome sequence and variation. Clients include academic, non-profit institutions and commercial biotech entities.

Contact: Suzanne B. Sandmeyer, Ph.D., Facility Director
Location: 30 Sprague Hall, Irvine, CA 92697-4035
Phone: 949-824-6023

University Laboratory Animal Resources (ULAR)

University Laboratory Animal Resources (ULAR) is committed to providing a top quality animal care program that promotes integrity and excellence in research and teaching in the biological and medical sciences.
Contact: 949-824-7788

For additional research facilities, please check with the School of Physical Sciences facilities and School of Medicine facilities.